Ultrasound and Microbubbles Enhance Uptake of Doxorubicin in Murine Kidneys.
doxorubicin
kidney
mice
microbubbles
sonoporation
ultrasound
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
29 Nov 2021
29 Nov 2021
Historique:
received:
08
10
2021
revised:
17
11
2021
accepted:
25
11
2021
entrez:
28
12
2021
pubmed:
29
12
2021
medline:
29
12
2021
Statut:
epublish
Résumé
The use of ultrasound and microbubble-enhanced drug delivery, commonly referred to as sonoporation, has reached numerous clinical trials and has shown favourable results. Nevertheless, the microbubbles and acoustic path also pass through healthy tissues. To date, the majority of studies have focused on the impact to diseased tissues and rarely evaluated the impact on healthy and collateral tissue. The aim of this study was to test the effect and feasibility of low-intensity sonoporation on healthy kidneys in a mouse model. In our work here, we used a clinical diagnostic ultrasound system (GE Vivid E9) with a C1-5 ultrasound transducer combined with a software modification for 20-µs-long pulses to induce the ultrasound-guided drug delivery of doxorubicin (DOX) in mice kidneys in combination with SonoVue
Identifiants
pubmed: 34959319
pii: pharmaceutics13122038
doi: 10.3390/pharmaceutics13122038
pmc: PMC8703523
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Norwegian Cancer Society
ID : 6833652
Organisme : Sanofi Genzyme
ID : GZ-2013-11022
Organisme : National Institute of Health
ID : R01CA199646
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