Pharmacokinetic Drug Interaction Study of Sorafenib and Morphine in Rats.
drug–drug interaction
morphine
pharmacokinetics
sorafenib
sorafenib N-oxide
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
16 Dec 2021
16 Dec 2021
Historique:
received:
19
11
2021
revised:
09
12
2021
accepted:
15
12
2021
entrez:
28
12
2021
pubmed:
29
12
2021
medline:
29
12
2021
Statut:
epublish
Résumé
A combination of the tyrosine kinase inhibitor-sorafenib-and the opioid analgesic-morphine-can be found in the treatment of cancer patients. Since both are substrates of P-glycoprotein (P-gp), and sorafenib is also an inhibitor of P-gp, their co-administration may affect their pharmacokinetics, and thus the safety and efficacy of cancer therapy. Therefore, the aim of this study was to evaluate the potential pharmacokinetic drug-drug interactions between sorafenib and morphine using an animal model. The rats were divided into three groups that Received: sorafenib and morphine (I
Identifiants
pubmed: 34959453
pii: pharmaceutics13122172
doi: 10.3390/pharmaceutics13122172
pmc: PMC8707786
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Curr Pharm Des. 2011;17(26):2829-42
pubmed: 21827411
J Pharm Pharmacol. 2012 Apr;64(4):496-504
pubmed: 22420656
Pharm Res. 2015 Aug;32(8):2477-502
pubmed: 25972096
Biochem Pharmacol. 2017 Apr 1;129:85-95
pubmed: 28065859
Pharmacogenomics. 2014 Jul;15(10):1297-309
pubmed: 25155932
Cancer Res. 2015 Jul 1;75(13):2729-36
pubmed: 25952649
Pharmacol Rep. 2012;64(4):870-7
pubmed: 23087138
Pharm Res. 2001 Jul;18(7):957-63
pubmed: 11496955
Drug Metab Dispos. 2019 Feb;47(2):135-144
pubmed: 30442649
Liver Int. 2020 Jan;40(1):32-44
pubmed: 31654604
Clin Pharmacol Ther. 2006 Apr;79(4):316-24
pubmed: 16580900
Br J Clin Pharmacol. 2000 Sep;50(3):237-46
pubmed: 10971308
Anesthesiology. 2002 Apr;96(4):913-20
pubmed: 11964599
Anesthesiology. 2013 Oct;119(4):941-53
pubmed: 23851346
J Pain Palliat Care Pharmacother. 2012 Dec;26(4):362-7
pubmed: 23216174
J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Sep 25;809(1):99-103
pubmed: 15282098
Biochem Pharmacol. 2013 Sep 1;86(5):666-78
pubmed: 23835420
Eur J Clin Pharmacol. 2020 Apr;76(4):579-587
pubmed: 31932871
Anesthesiology. 2000 May;92(5):1392-9
pubmed: 10781286
Nat Rev Dis Primers. 2017 Mar 09;3:17009
pubmed: 28276433
Pharmacogenet Genomics. 2017 Jun;27(6):240-246
pubmed: 28362716
J Neurochem. 2003 Sep;86(6):1564-7
pubmed: 12950465
J Pain Palliat Care Pharmacother. 2013 Aug;27(3):261-7
pubmed: 23879227
Br J Pharmacol. 1999 Oct;128(3):563-8
pubmed: 10516633
Expert Rev Gastroenterol Hepatol. 2019 Feb;13(2):179-187
pubmed: 30791782
Biochem Pharmacol. 1999 Sep 15;58(6):951-7
pubmed: 10509747
Pharmacol Rep. 2020 Feb;72(1):254-259
pubmed: 32016844
Clin Pharmacol Ther. 2020 Jan;107(1):227-237
pubmed: 31350763
Psychopharmacology (Berl). 2014 Aug;231(16):3139-49
pubmed: 24705903
Eur J Pharmacol. 2002 Apr 5;440(1):7-16
pubmed: 11959083
Drug Metab Pharmacokinet. 2020 Feb;35(1):2-11
pubmed: 31996310
Pharm Res. 1998 Apr;15(4):599-605
pubmed: 9587957
Oncol Ther. 2020 Dec;8(2):251-259
pubmed: 32894414
Mol Pharmacol. 2007 Aug;72(2):387-94
pubmed: 17485564
Lancet Oncol. 2014 Jul;15(8):e315-26
pubmed: 24988935
Metabolites. 2021 Jan 27;11(2):
pubmed: 33513941
Life Sci. 2000;66(4):PL47-51
pubmed: 10665989
Xenobiotica. 2016 Jul;46(7):651-658
pubmed: 26582036
J Pharm Pharmacol. 2010 Mar;62(3):310-4
pubmed: 20487213
Biomed Pharmacother. 2020 Oct;130:110530
pubmed: 32712531
In Vivo. 2017 Sep-Oct;31(5):811-817
pubmed: 28882946
Lancet. 2016 Dec 3;388(10061):2783-2795
pubmed: 27240885
J Pharmacol Sci. 2007 Dec;105(4):353-60
pubmed: 18071274
Pharm Res. 2000 Jun;17(6):749-53
pubmed: 10955852
J Vet Pharmacol Ther. 2011 Oct;34(5):417-23
pubmed: 21241325
Metab Brain Dis. 2012 Mar;27(1):1-5
pubmed: 22193538
J Clin Invest. 1995 Oct;96(4):1698-705
pubmed: 7560060
Pharm Biol. 2017 Dec;55(1):1863-1867
pubmed: 28614959
Br J Clin Pharmacol. 2015 Feb;79(2):241-53
pubmed: 25125025
J Neurochem. 2002 Oct;83(2):241-8
pubmed: 12423235
Invest New Drugs. 2009 Feb;27(1):31-40
pubmed: 18449471
Clin Pharmacol Ther. 2008 Apr;83(4):559-66
pubmed: 17898703