Hepatitis E Virus Infection: Neurological Manifestations and Pathophysiology.
extra-hepatic manifestations
hepatitis E virus
neurological manifestations
Journal
Pathogens (Basel, Switzerland)
ISSN: 2076-0817
Titre abrégé: Pathogens
Pays: Switzerland
ID NLM: 101596317
Informations de publication
Date de publication:
03 Dec 2021
03 Dec 2021
Historique:
received:
12
11
2021
revised:
30
11
2021
accepted:
01
12
2021
entrez:
28
12
2021
pubmed:
29
12
2021
medline:
29
12
2021
Statut:
epublish
Résumé
Hepatitis E virus (HEV) is the first cause of viral hepatitis in the world. While the water-borne HEV genotypes 1 and 2 are found in developing countries, HEV genotypes 3 and 4 are endemic in developed countries due to the existence of animal reservoirs, especially swine. An HEV infection produces many extra-hepatic manifestations in addition to liver symptoms, especially neurological disorders. The most common are neuralgic amyotrophy or Parsonage-Turner syndrome, Guillain-Barré syndrome, myelitis, and encephalitis. The pathophysiology of the neurological injuries due to HEV remains uncertain. The immune response to the virus probably plays a role, but direct virus neurotropism could also contribute to the pathophysiology. This review describes the main neurological manifestations and their possible pathogenic mechanisms.
Identifiants
pubmed: 34959537
pii: pathogens10121582
doi: 10.3390/pathogens10121582
pmc: PMC8705630
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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