Prenatal Iron Deficiency and Choline Supplementation Interact to Epigenetically Regulate
Animals
Brain-Derived Neurotrophic Factor
/ genetics
Choline
/ administration & dosage
DNA-Binding Proteins
/ genetics
Dietary Supplements
Epigenesis, Genetic
Female
Hippocampus
/ drug effects
Iron Deficiencies
Jumonji Domain-Containing Histone Demethylases
/ genetics
Nuclear Proteins
/ metabolism
Pregnancy
Prenatal Exposure Delayed Effects
Rats
Repressor Proteins
/ metabolism
Bdnf
Jarid1b
choline
epigenetics
gene expression
histone modification
iron deficiency
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
17 Dec 2021
17 Dec 2021
Historique:
received:
19
11
2021
revised:
10
12
2021
accepted:
14
12
2021
entrez:
28
12
2021
pubmed:
29
12
2021
medline:
15
1
2022
Statut:
epublish
Résumé
Early-life iron deficiency (ID) causes long-term neurocognitive impairments and gene dysregulation that can be partially mitigated by prenatal choline supplementation. The long-term gene dysregulation is hypothesized to underlie cognitive dysfunction. However, mechanisms by which iron and choline mediate long-term gene dysregulation remain unknown. In the present study, using a well-established rat model of fetal-neonatal ID, we demonstrated that ID downregulated hippocampal expression of the gene encoding JmjC-ARID domain-containing protein 1B (JARID1B), an iron-dependent histone H3K4 demethylase, associated with a higher histone deacetylase 1 (HDAC1) enrichment and a lower enrichment of acetylated histone H3K9 (H3K9ac) and phosphorylated cAMP response element-binding protein (pCREB). Likewise, ID reduced transcriptional capacity of the gene encoding brain-derived neurotrophic factor (BDNF), a target of JARID1B, associated with repressive histone modifications such as lower H3K9ac and pCREB enrichments at the
Identifiants
pubmed: 34960080
pii: nu13124527
doi: 10.3390/nu13124527
pmc: PMC8706459
pii:
doi:
Substances chimiques
Bdnf protein, rat
0
Brain-Derived Neurotrophic Factor
0
DNA-Binding Proteins
0
Nuclear Proteins
0
Repressor Proteins
0
Jumonji Domain-Containing Histone Demethylases
EC 1.14.11.-
Kdm5b protein, rat
EC 1.14.11.-
Choline
N91BDP6H0X
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NINDS NIH HHS
ID : R01 NS099178
Pays : United States
Organisme : NIH HHS
ID : UL1TR002494
Pays : United States
Organisme : NIH HHS
ID : R01HD29421
Pays : United States
Organisme : NIH HHS
ID : R01NS099178
Pays : United States
Références
Behav Neurosci. 2007 Jun;121(3):475-82
pubmed: 17592938
Cold Spring Harb Perspect Med. 2018 Apr 2;8(4):
pubmed: 28495803
Hippocampus. 2012 Aug;22(8):1691-702
pubmed: 22367974
Metallomics. 2012 Oct;4(10):1020-36
pubmed: 22991063
J Am Coll Nutr. 2004 Dec;23(6 Suppl):621S-626S
pubmed: 15640516
Cell. 2007 Feb 23;128(4):693-705
pubmed: 17320507
Mol Cell Biol. 2008 Sep;28(17):5312-27
pubmed: 18591252
Pediatr Res. 2009 May;65(5):493-8
pubmed: 19190544
Pediatrics. 2000 Apr;105(4):E51
pubmed: 10742372
FASEB J. 2002 Apr;16(6):619-21
pubmed: 11919173
Diabetes. 2005 May;54(5):1452-8
pubmed: 15855333
Public Health Nutr. 2009 Apr;12(4):444-54
pubmed: 18498676
J Biol Chem. 2012 Dec 28;287(53):44508-17
pubmed: 23152497
Mol Neurobiol. 2019 Dec;56(12):8408-8419
pubmed: 31250382
Science. 2007 Oct 19;318(5849):444-7
pubmed: 17947579
Arch Gen Psychiatry. 2008 Oct;65(10):1136-44
pubmed: 18838630
Neuropharmacology. 2014 Jan;76 Pt C:628-38
pubmed: 23752094
Genes Dev. 2010 Feb 15;24(4):368-80
pubmed: 20123894
Brain Res. 2008 Oct 27;1237:153-66
pubmed: 18778697
Am J Physiol Endocrinol Metab. 2012 Feb 1;302(3):E316-24
pubmed: 22068601
Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4260-5
pubmed: 19255431
J Neurosci. 2017 Jan 4;37(1):1-10
pubmed: 28053025
Biochem J. 2014 Sep 15;462(3):385-95
pubmed: 25145438
Nutrients. 2021 Jan 26;13(2):
pubmed: 33530485
FASEB J. 2006 Jan;20(1):43-9
pubmed: 16394266
Cereb Cortex. 2018 Feb 1;28(2):538-548
pubmed: 27999124
Physiol Rep. 2013 Oct;1(5):e00096
pubmed: 24303168
Aging Cell. 2020 Jun;19(6):e13153
pubmed: 32419307
Pediatr Res. 2019 Jan;85(2):176-182
pubmed: 30341413
Nutr Rev. 2009 Nov;67(11):615-23
pubmed: 19906248
Physiol Rev. 2009 Jan;89(1):121-45
pubmed: 19126756
EMBO J. 2011 Nov 16;30(22):4586-600
pubmed: 22020125
Dev Neurosci. 2010 Aug;32(3):238-48
pubmed: 20689287
J Biol Chem. 2014 Oct 10;289(41):28095-103
pubmed: 25160626
J Nutr. 2016 Mar;146(3):484-93
pubmed: 26865644
Hippocampus. 2013 Oct;23(10):952-62
pubmed: 23733517
Int J Cancer. 2007 Jul 15;121(2):265-75
pubmed: 17373667
Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):8971-6
pubmed: 22615382
J Nutr. 2018 Oct 1;148(10):1521-1528
pubmed: 30169712
Cell. 2010 May 14;141(4):583-94
pubmed: 20478252
Dev Cogn Neurosci. 2012 Jan;2(1):174-80
pubmed: 22229050
PLoS Genet. 2013 Apr;9(4):e1003461
pubmed: 23637629
Mol Biol Cell. 2016 Feb 15;27(4):627-39
pubmed: 26739753
Lancet Glob Health. 2013 Jul;1(1):e16-25
pubmed: 25103581
Am J Physiol Regul Integr Comp Physiol. 2015 Feb 15;308(4):R276-82
pubmed: 25519736
Mol Cell Biol. 2003 Aug;23(15):5293-300
pubmed: 12861015
Hippocampus. 2007;17(8):679-91
pubmed: 17546681
Brain Res. 2008 Oct 27;1237:110-23
pubmed: 18786518
J Biol Chem. 2009 Jan 23;284(4):1982-9
pubmed: 19001366
J Nutr. 2013 Mar;143(3):260-6
pubmed: 23303869
Cell. 2007 Mar 9;128(5):889-900
pubmed: 17320163
J Pediatr. 2013 Nov;163(5):1260-6
pubmed: 23827739
Cell. 2004 Dec 17;119(6):873-87
pubmed: 15607982
Biomed Pharmacother. 2020 Sep;129:110392
pubmed: 32574968
Neural Plast. 2018 Jun 11;2018:2682037
pubmed: 29991943
Nutrients. 2019 May 27;11(5):
pubmed: 31137889
FASEB J. 2010 Jan;24(1):184-95
pubmed: 19752176
Am J Phys Anthropol. 1998;Suppl 27:177-209
pubmed: 9881526
Dev Neurosci. 2003 Nov-Dec;25(6):412-20
pubmed: 14966382
Cent Nerv Syst Agents Med Chem. 2012 Jun;12(2):82-94
pubmed: 22483275
Adv Nutr. 2011 Mar;2(2):112-21
pubmed: 22332040
Mol Cell Neurosci. 2016 Mar;71:56-65
pubmed: 26689905
J Nutr. 2009 Apr;139(4):672-9
pubmed: 19211831
Am J Epidemiol. 2014 Nov 1;180(9):890-900
pubmed: 25249546
Nature. 2010 Mar 11;464(7286):306-10
pubmed: 20075857
J Mol Biol. 2014 Oct 9;426(20):3467-77
pubmed: 24747049
Mol Psychiatry. 2021 Aug;26(8):3701-3722
pubmed: 33106599
J Biol Chem. 2016 Feb 19;291(8):4004-18
pubmed: 26655717
Behav Brain Res. 2018 Jan 15;336:40-43
pubmed: 28811181
Mol Psychiatry. 2014 Nov;19(11):1227-34
pubmed: 24419041
J Nutr. 2014 Nov;144(11):1858-65
pubmed: 25332485
Mol Cell. 2010 Jan 15;37(1):46-56
pubmed: 20129054
Hippocampus. 2015 Nov;25(11):1380-92
pubmed: 25820928
Genes Dev. 2010 Mar 15;24(6):590-601
pubmed: 20231316