The Importance of Nanocarrier Design and Composition for an Efficient Nanoparticle-Mediated Transdermal Vaccination.
nano vaccines
nanomedicine
nanoparticle design
needle-free immunization
transdermal vaccines
Journal
Vaccines
ISSN: 2076-393X
Titre abrégé: Vaccines (Basel)
Pays: Switzerland
ID NLM: 101629355
Informations de publication
Date de publication:
01 Dec 2021
01 Dec 2021
Historique:
received:
01
10
2021
revised:
22
11
2021
accepted:
23
11
2021
entrez:
28
12
2021
pubmed:
29
12
2021
medline:
29
12
2021
Statut:
epublish
Résumé
The World Health Organization estimates that the pandemic caused by the SARS-CoV-2 virus claimed more than 3 million lives in 2020 alone. This situation has highlighted the importance of vaccination programs and the urgency of working on new technologies that allow an efficient, safe, and effective immunization. From this perspective, nanomedicine has provided novel tools for the design of the new generation of vaccines. Among the challenges of the new vaccine generations is the search for alternative routes of antigen delivery due to costs, risks, need for trained personnel, and low acceptance in the population associated with the parenteral route. Along these lines, transdermal immunization has been raised as a promising alternative for antigen delivery and vaccination based on a large absorption surface and an abundance of immune system cells. These features contribute to a high barrier capacity and high immunological efficiency for transdermal immunization. However, the stratum corneum barrier constitutes a significant challenge for generating new pharmaceutical forms for transdermal antigen delivery. This review addresses the biological bases for transdermal immunomodulation and the technological advances in the field of nanomedicine, from the passage of antigens facilitated by devices to cross the stratum corneum, to the design of nanosystems, with an emphasis on the importance of design and composition towards the new generation of needle-free nanometric transdermal systems.
Identifiants
pubmed: 34960166
pii: vaccines9121420
doi: 10.3390/vaccines9121420
pmc: PMC8705631
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Fondecyt Regular
ID : 1201482
Organisme : Interdisciplinary Project, Pontificia Universidad Católica de Chile.
ID : 2020
Références
Nano Rev Exp. 2017 Jun 07;8(1):1325708
pubmed: 30410704
Int J Pharm. 2015 Apr 10;483(1-2):110-4
pubmed: 25681719
J Pharm Sci. 2004 Jun;93(6):1415-30
pubmed: 15124201
Proc Natl Acad Sci U S A. 2021 Nov 9;118(45):
pubmed: 34670842
Int J Pharm. 2017 Jan 10;516(1-2):225-230
pubmed: 27832955
J Invest Dermatol. 2007 Jul;127(7):1701-12
pubmed: 17380118
PLoS Comput Biol. 2018 Feb 26;14(2):e1006006
pubmed: 29481568
J Infect Dis. 2018 Jun 5;218(1):124-132
pubmed: 29701813
Biotechnol Adv. 2015 Nov 1;33(6 Pt 3):1279-93
pubmed: 26049133
Molecules. 2020 Jun 27;25(13):
pubmed: 32605117
Int J Nanomedicine. 2017 Apr 26;12:3357-3364
pubmed: 28490875
Eur J Pharm Biopharm. 2014 Feb;86(2):267-76
pubmed: 24120887
Ther Deliv. 2015;6(9):1081-8
pubmed: 26419290
J Dermatol Sci. 2017 Feb;85(2):106-114
pubmed: 27839630
Vaccines (Basel). 2021 May 26;9(6):
pubmed: 34073648
Nat Immunol. 2016 Jan;17(1):48-56
pubmed: 26523865
Nat Biotechnol. 2008 Nov;26(11):1261-8
pubmed: 18997767
Vaccines (Basel). 2021 Apr 01;9(4):
pubmed: 33915696
Nature. 1998 Mar 19;392(6673):245-52
pubmed: 9521319
Eur J Pharm Biopharm. 2015 Nov;97(Pt A):51-9
pubmed: 26455338
Pharmaceutics. 2019 May 26;11(5):
pubmed: 31130688
J Pharm Pharmacol. 2005 Mar;57(3):295-301
pubmed: 15807984
Drug Deliv. 2016 Sep;23(7):2391-2398
pubmed: 25625495
Eur J Pharm Sci. 2020 Aug 1;151:105410
pubmed: 32505795
Int J Pharm. 2007 Aug 1;340(1-2):13-9
pubmed: 17446015
ACS Nano. 2021 Sep 28;15(9):14347-14359
pubmed: 34472328
Nanomaterials (Basel). 2018 Aug 26;8(9):
pubmed: 30149658
Biotechnol J. 2016 Nov;11(11):1375-1385
pubmed: 27529824
J Control Release. 2015 May 28;206:140-52
pubmed: 25795506
NPJ Vaccines. 2017 Sep 8;2:25
pubmed: 29263880
Int J Pharm. 2010 Sep 15;397(1-2):164-72
pubmed: 20599487
Nat Commun. 2016 Nov 30;7:13520
pubmed: 27901019
Immunol Lett. 2017 Jul;187:19-26
pubmed: 28479111
Chem Phys Lipids. 1993 Sep;64(1-3):3-18
pubmed: 8242840
Nat Rev Immunol. 2001 Nov;1(2):135-45
pubmed: 11905821
Adv Funct Mater. 2016 Apr 19;26(15):2512-2522
pubmed: 27833475
Indian J Pharm Sci. 2011 May;73(3):323-8
pubmed: 22457561
Expert Opin Drug Deliv. 2021 Jul;18(7):929-947
pubmed: 32975144
J Cell Mol Med. 2020 Oct;24(20):11646-11655
pubmed: 32916775
J Immunol. 2014 Oct 1;193(7):3717-25
pubmed: 25156365
J Ethnopharmacol. 2021 Jan 30;265:113294
pubmed: 32841693
Lancet. 2014 Aug 23;384(9944):674-81
pubmed: 24881803
Colloids Surf B Biointerfaces. 2018 Dec 1;172:323-329
pubmed: 30176512
J Control Release. 2019 Aug 28;308:14-28
pubmed: 31265882
Theranostics. 2019 Jan 1;9(1):48-64
pubmed: 30662553
Nat Commun. 2018 Sep 7;9(1):3644
pubmed: 30194294
Arch Dermatol Res. 2010 Jan;302(1):47-55
pubmed: 19701759
Nanomedicine. 2015 Jan;11(1):147-54
pubmed: 25200611
Eur J Lipid Sci Technol. 2014 Sep;116(9):1088-1107
pubmed: 25400504
AAPS J. 2015 Jan;17(1):216-26
pubmed: 25387996
J Dermatol Sci. 2017 Sep;87(3):252-259
pubmed: 28655469
Immunology. 2020 Jun;160(2):116-125
pubmed: 31709535
ACS Nano. 2018 Oct 23;12(10):10272-10280
pubmed: 30272942
Vaccines (Basel). 2020 Oct 20;8(4):
pubmed: 33092277
Pharm Res. 2020 Sep 17;37(10):195
pubmed: 32944793
Drug Deliv Transl Res. 2021 Aug 20;:
pubmed: 34415566
Vaccine. 2015 Aug 26;33(36):4630-8
pubmed: 26141014
J Control Release. 2021 May 10;333:511-520
pubmed: 33798667
Pharmaceutics. 2020 May 21;12(5):
pubmed: 32455797
BMJ. 2020 Dec 2;371:m4709
pubmed: 33268462
Eur J Pharm Biopharm. 2018 Jul;128:119-130
pubmed: 29660407
J Control Release. 2007 Jul 31;120(3):211-9
pubmed: 17582639
Expert Rev Vaccines. 2010 Dec;9(12):1399-409
pubmed: 21105776
Adv Healthc Mater. 2017 Jan;6(1):
pubmed: 28075069
Annu Rev Immunol. 2020 Apr 26;38:171-202
pubmed: 32340577
Curr Opin Pediatr. 2012 Jun;24(3):371-8
pubmed: 22572760
Int J Pharm. 2013 Apr 15;447(1-2):12-21
pubmed: 23462366
Drug Deliv. 2020 Dec;27(1):1087-1093
pubmed: 32706279
Bioeng Transl Med. 2018 Oct 26;4(1):38-50
pubmed: 30680317
J Control Release. 2020 Nov 10;327:88-99
pubmed: 32763432
J Control Release. 2021 Sep 10;337:258-284
pubmed: 34293319
Int Immunopharmacol. 2020 Jun;83:106446
pubmed: 32244048
Ann Intern Med. 2021 Feb;174(2):JC15
pubmed: 33524290
Anal Chim Acta. 2007 Aug 6;597(2):179-86
pubmed: 17683728
Vaccine. 2017 Aug 16;35(35 Pt A):4475-4479
pubmed: 28629921
PLoS One. 2021 Mar 11;16(3):e0247990
pubmed: 33705411
Oncogene. 2020 Jun;39(24):4756-4769
pubmed: 32427988
Cancers (Basel). 2020 Apr 13;12(4):
pubmed: 32295072
J Control Release. 2016 Oct 28;240:77-92
pubmed: 26518723
J Pharm Sci. 2009 Feb;98(2):565-72
pubmed: 18563737
Biomaterials. 2008 May;29(13):2113-24
pubmed: 18261792
Pharm Res. 2010 Jan;27(1):115-25
pubmed: 19911256
Eur J Pharm Sci. 2016 Oct 10;93:437-46
pubmed: 27575879
Immunology. 2020 Jun;160(2):149-156
pubmed: 32173857
J Eur Acad Dermatol Venereol. 2019 Jun;33(6):1177-1188
pubmed: 30720896
Biomed Pharmacother. 2016 Oct;83:1080-1088
pubmed: 27544552
Molecules. 2017 May 22;22(5):
pubmed: 28531163
Drug Discov Today. 2016 May;21(5):789-801
pubmed: 26780385
Pharm Dev Technol. 2019 Jun;24(5):630-638
pubmed: 30457418
ACS Appl Nano Mater. 2020 Aug 28;3(8):8037-8051
pubmed: 33969278
Int J Pharm. 2003 Mar 6;253(1-2):71-80
pubmed: 12593938
PLoS One. 2009;4(3):e4773
pubmed: 19274084
Pharmaceutics. 2020 Jun 19;12(6):
pubmed: 32575392
Clin J Am Soc Nephrol. 2021 Jul;16(7):1037-1042
pubmed: 33824157
Nanomedicine (Lond). 2014 Oct;9(15):2273-89
pubmed: 24673264
Nanomedicine (Lond). 2021 Jun;16(14):1203-1218
pubmed: 33988035
J Infect Dis. 2019 Nov 6;220(12):1926-1934
pubmed: 31408163
Front Immunol. 2018 Apr 19;9:791
pubmed: 29725329
J Control Release. 2013 Dec 28;172(3):894-903
pubmed: 23978683
Sci Rep. 2018 Nov 30;8(1):17508
pubmed: 30504893
Biomed Tech (Berl). 2020 May 26;65(3):243-272
pubmed: 31926064
Langmuir. 2015 Feb 3;31(4):1556-63
pubmed: 25580808
Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):370-377
pubmed: 30691310
Front Immunol. 2018 Jan 18;9:26
pubmed: 29403503
Nat Rev Immunol. 2008 Dec;8(12):935-47
pubmed: 19029989
Sci Rep. 2017 Mar 28;7:45292
pubmed: 28349970
Br J Dermatol. 1998 Apr;138(4):583-92
pubmed: 9640361
ACS Appl Bio Mater. 2021 Jun 21;4(6):4953-4961
pubmed: 34179728
Oncotarget. 2017 Jun 13;8(24):38214-38226
pubmed: 28465469
J Colloid Interface Sci. 2015 Jul 1;449:317-26
pubmed: 25533536
Pharmaceutics. 2020 Sep 09;12(9):
pubmed: 32916782
Hum Vaccin Immunother. 2014;10(2):321-32
pubmed: 24128651
Pharmaceutics. 2015 Oct 22;7(4):438-70
pubmed: 26506371
J Immunol. 2021 Feb 15;206(4):700-711
pubmed: 33380496
Adv Colloid Interface Sci. 2014 Mar;205:187-206
pubmed: 24369107
J Invest Dermatol. 1988 Sep;91(3):283
pubmed: 3045211
Clin Microbiol Infect. 2021 Nov;27(11):1652-1657
pubmed: 34245907
J Control Release. 2014 Nov 10;193:257-69
pubmed: 24801250
NPJ Vaccines. 2018 Jun 5;3:22
pubmed: 29900011
Int J Pharm. 2020 Aug 30;586:119390
pubmed: 32540349
BMJ. 2020 Dec 11;371:m4826
pubmed: 33310706
Hum Vaccin Immunother. 2016 Apr 2;12(4):990-2
pubmed: 26810033
J Pharm Pharmacol. 2012 Nov;64(11):1560-9
pubmed: 23058043
J Cell Biol. 1982 Jun;93(3):551-9
pubmed: 6181071
Drug Discov Today. 2018 Jan;23(1):181-186
pubmed: 28988995
Bull World Health Organ. 2020 Feb 1;98(2):146-148
pubmed: 32015586
Sci Transl Med. 2020 Jul 1;12(550):
pubmed: 32611683
J Control Release. 2018 Sep 28;286:20-32
pubmed: 30017722
Sci Rep. 2019 Oct 10;9(1):14617
pubmed: 31601936
Mater Sci Eng C Mater Biol Appl. 2019 Jun;99:1448-1458
pubmed: 30889679
Int J Pharm. 2017 Nov 25;533(1):179-186
pubmed: 28887219
Anal Bioanal Chem. 2018 Nov;410(27):7249-7260
pubmed: 30171282
Pharm Res. 2021 Jun;38(6):947-970
pubmed: 34036520
AAPS PharmSciTech. 2018 Jan;19(1):481-488
pubmed: 28828737
Int J Pharm. 2005 Apr 11;293(1-2):73-82
pubmed: 15778046
Biomed Pharmacother. 2019 Jan;109:1249-1258
pubmed: 30551375
Eur J Pharm Sci. 2017 May 1;102:230-236
pubmed: 28323115
Colloid Interface Sci Commun. 2021 Nov;45:100533
pubmed: 34692429
J Control Release. 2021 Jul 10;335:449-456
pubmed: 34029632
Int J Pharm. 2011 Apr 15;408(1-2):20-6
pubmed: 21272624
J Biomed Nanotechnol. 2020 Dec 1;16(12):1776-1786
pubmed: 33485404
Colloids Surf B Biointerfaces. 2018 Mar 1;163:184-191
pubmed: 29294420
Expert Opin Drug Deliv. 2020 Mar;17(3):357-377
pubmed: 32064958
Pharm Res. 2018 Aug 13;35(10):189
pubmed: 30105542
Nat Med. 2020 Mar;26(3):341-347
pubmed: 32152581
Eur J Pharm Sci. 2008 Oct 2;35(3):193-202
pubmed: 18657610
Vaccine. 2001 Apr 30;19(23-24):3301-10
pubmed: 11312029
J Cosmet Dermatol. 2014 Mar;13(1):38-43
pubmed: 24641604
Iran J Basic Med Sci. 2018 May;21(5):536-545
pubmed: 29922436
MMWR Morb Mortal Wkly Rep. 2021 May 21;70(20):753-758
pubmed: 34014909
Pharmaceutics. 2020 Dec 30;13(1):
pubmed: 33396817
Pharm Dev Technol. 2017 Jun;22(4):458-466
pubmed: 26608060
Nanomedicine. 2016 Nov;12(8):2439-2448
pubmed: 27431054
Adv Drug Deliv Rev. 2020;154-155:227-235
pubmed: 32589904