Systemic Inflammation and Complement Activation Parameters Predict Clinical Outcome of Severe SARS-CoV-2 Infections.
NETosis
SARS-CoV-2
complement
infectious disease
tracheal fluid
viral infection
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
26 11 2021
26 11 2021
Historique:
received:
20
10
2021
revised:
22
11
2021
accepted:
23
11
2021
entrez:
28
12
2021
pubmed:
29
12
2021
medline:
19
1
2022
Statut:
epublish
Résumé
Overactivation of the complement system has been characterized in severe COVID-19 cases. Complement components are known to trigger NETosis via the coagulation cascade and have also been reported in human tracheobronchial epithelial cells. In this longitudinal study, we investigated systemic and local complement activation and NETosis in COVID-19 patients that underwent mechanical ventilation. Results confirmed significantly higher baseline levels of serum C5a (24.5 ± 39.0 ng/mL) and TCC (11.03 ± 8.52 µg/mL) in patients compared to healthy controls (
Identifiants
pubmed: 34960645
pii: v13122376
doi: 10.3390/v13122376
pmc: PMC8707937
pii:
doi:
Substances chimiques
Cytokines
0
Complement C5a
80295-54-1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : FWF Austrian Science Fund
ID : W1253
Organisme : Horizon 2020
ID : 860044
Références
Int J Occup Environ Med. 2020 Feb 5;11(2):65-71
pubmed: 32020915
Am J Respir Cell Mol Biol. 2013 Aug;49(2):221-30
pubmed: 23526211
Proteome Sci. 2011 Jan 20;9:4
pubmed: 21251289
Am J Trop Med Hyg. 2020 Aug;103(2):822-827
pubmed: 32618262
Clin Infect Dis. 2021 May 14;:
pubmed: 33988226
Pathog Dis. 2019 Dec 1;77(9):
pubmed: 32065221
Proc Natl Acad Sci U S A. 2020 Oct 6;117(40):25018-25025
pubmed: 32943538
N Engl J Med. 2020 Mar 19;382(12):1177-1179
pubmed: 32074444
Complement. 1986;3(1):25-39
pubmed: 3743034
Sci Rep. 2021 Aug 3;11(1):15701
pubmed: 34344929
Arterioscler Thromb Vasc Biol. 2021 Feb;41(2):988-994
pubmed: 33267662
J Allergy Clin Immunol. 2020 Jul;146(1):215-217
pubmed: 32417135
J Clin Med. 2021 May 19;10(10):
pubmed: 34069355
Emerg Microbes Infect. 2018 Apr 24;7(1):77
pubmed: 29691378
Nat Med. 2020 Oct;26(10):1609-1615
pubmed: 32747830
JCI Insight. 2020 Aug 6;5(15):
pubmed: 32554923
J Infect Dis. 2014 May 1;209(9):1331-42
pubmed: 24065148
Emerg Microbes Infect. 2015 May;4(5):e28
pubmed: 26060601
N Engl J Med. 2020 Apr 30;382(18):1708-1720
pubmed: 32109013
J Infect Dis. 2021 Feb 3;223(2):214-224
pubmed: 33038254
Complement Inflamm. 1990;7(4-6):290-7
pubmed: 2088668
mBio. 2018 Oct 9;9(5):
pubmed: 30301856
Sci Immunol. 2021 May 13;6(59):
pubmed: 34446527
Blood. 2020 Oct 29;136(18):2080-2089
pubmed: 32877502
J Exp Med. 2020 Dec 7;217(12):
pubmed: 32926098
J Clin Invest. 2020 Nov 2;130(11):6151-6157
pubmed: 32759504
Front Immunol. 2021 Sep 10;12:742446
pubmed: 34567008
Annu Rev Immunol. 2005;23:821-52
pubmed: 15771587
Immunity. 2021 Jun 8;54(6):1257-1275.e8
pubmed: 34051148
Cell Mol Immunol. 2019 Jan;16(1):19-27
pubmed: 29572545
Front Immunol. 2021 Feb 22;12:627579
pubmed: 33692801
J Allergy Clin Immunol. 2020 Jul;146(1):128-136.e4
pubmed: 32425269
Am J Physiol Lung Cell Mol Physiol. 2009 Jan;296(1):L92-L100
pubmed: 18931053
Nature. 2020 Dec;588(7836):146-150
pubmed: 32726800
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
Biomedicines. 2021 Aug 12;9(8):
pubmed: 34440207
Front Immunol. 2021 Jul 05;12:714511
pubmed: 34290717
Clin Chem Lab Med. 2021 Aug 30;59(12):1988-1997
pubmed: 34455731
Cell. 2020 Jul 9;182(1):59-72.e15
pubmed: 32492406
Eur Radiol Exp. 2020 Dec 15;4(1):68
pubmed: 33319321