Fullerene Derivatives Prevent Packaging of Viral Genomic RNA into HIV-1 Particles by Binding Nucleocapsid Protein.
Anti-HIV Agents
/ metabolism
Fullerenes
/ metabolism
Genome, Viral
/ drug effects
HEK293 Cells
HIV-1
/ drug effects
Humans
Nucleocapsid Proteins
/ metabolism
Protein Binding
RNA, Viral
/ metabolism
Reverse Transcription
Viral Genome Packaging
/ drug effects
Virion
/ metabolism
Virus Uncoating
/ drug effects
gag Gene Products, Human Immunodeficiency Virus
/ metabolism
HIV-1
RNA packaging
fullerene
inhibition
nucleocapsid
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
06 12 2021
06 12 2021
Historique:
received:
10
11
2021
revised:
01
12
2021
accepted:
02
12
2021
entrez:
28
12
2021
pubmed:
29
12
2021
medline:
15
2
2022
Statut:
epublish
Résumé
Fullerene derivatives with hydrophilic substituents have been shown to exhibit a range of biological activities, including antiviral ones. For a long time, the anti-HIV activity of fullerene derivatives was believed to be due to their binding into the hydrophobic pocket of HIV-1 protease, thereby blocking its activity. Recent work, however, brought new evidence of a novel, protease-independent mechanism of fullerene derivatives' action. We studied in more detail the mechanism of the anti-HIV-1 activity of
Identifiants
pubmed: 34960720
pii: v13122451
doi: 10.3390/v13122451
pmc: PMC8705927
pii:
doi:
Substances chimiques
Anti-HIV Agents
0
Fullerenes
0
Nucleocapsid Proteins
0
RNA, Viral
0
gag Gene Products, Human Immunodeficiency Virus
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Commentaires et corrections
Type : ErratumIn
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