Novel cannula design improves large volume auto-injection rates for high viscosity solutions.

Large volume subcutaneous injection autoinjector high viscosity injection depth in vivo pre-filled syringe tissue response ultra-thin wall cannula

Journal

Drug delivery
ISSN: 1521-0464
Titre abrégé: Drug Deliv
Pays: England
ID NLM: 9417471

Informations de publication

Date de publication:
Dec 2022
Historique:
entrez: 28 12 2021
pubmed: 29 12 2021
medline: 24 2 2022
Statut: ppublish

Résumé

A prototype reusable large-volume (2 mL) autoinjector (LVAI) was designed to compare injection performance of a novel 27 gauge ultra-thin wall (UTW) pre-filled syringe (PFS) cannula (8 mm external cannula length, 14.4 mm total needle length) against an existing 27 gauge special thin wall (STW) PFS cannula (12.7 mm external cannula length, 19 mm total needle length) across a range of injectate viscosities (2.3-30 cP) in a series of

Identifiants

pubmed: 34962225
doi: 10.1080/10717544.2021.2018069
pmc: PMC8725910
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

43-51

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Auteurs

Bruce C Roberts (BC)

Translational and Clinical Sciences Center of Excellence, BD Technologies and Innovation, Research Triangle Park, NC, USA.

Christopher Rini (C)

Translational and Clinical Sciences Center of Excellence, BD Technologies and Innovation, Research Triangle Park, NC, USA.

Rick Klug (R)

Translational and Clinical Sciences Center of Excellence, BD Technologies and Innovation, Research Triangle Park, NC, USA.

Douglas B Sherman (DB)

Translational and Clinical Sciences Center of Excellence, BD Technologies and Innovation, Research Triangle Park, NC, USA.

Didier Morel (D)

BD Clinical Development, Pont-de-Claix, France.

Ronald J Pettis (RJ)

Translational and Clinical Sciences Center of Excellence, BD Technologies and Innovation, Research Triangle Park, NC, USA.

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Classifications MeSH