Revealing the Photophysical and Photochemical Reaction Processes of Carprofen in Different Solutions via Ultrafast Femtosecond to Nanosecond Transient Absorption.
Journal
Chemical research in toxicology
ISSN: 1520-5010
Titre abrégé: Chem Res Toxicol
Pays: United States
ID NLM: 8807448
Informations de publication
Date de publication:
17 01 2022
17 01 2022
Historique:
pubmed:
29
12
2021
medline:
3
3
2022
entrez:
28
12
2021
Statut:
ppublish
Résumé
Carprofen (CP), one kind of a nonsteroidal anti-inflammatory drug, exhibits phototoxic side effects in physiology, while its phototoxic mechanism is ambiguous. To uncover CP's photophysical and photochemical reaction processes, femtosecond to nanosecond transient absorption spectroscopies were employed to directly detect excited states and transient intermediates of CP upon UV irradiation in pure acetonitrile (MeCN), MeCN/water 1:1, and acid/alkaline buffer solutions. The transient absorption data together with DFT calculations were integrated to elucidate mechanisms for photochemical reactions of CP in different solutions. The associated photophysical and photochemical reaction pathways are dependent on various solution environments. In a pure MeCN solvent, CP is excited to a singlet state (S
Identifiants
pubmed: 34962376
doi: 10.1021/acs.chemrestox.1c00315
doi:
Substances chimiques
Acetonitriles
0
Anti-Inflammatory Agents, Non-Steroidal
0
Carbazoles
0
Solutions
0
Water
059QF0KO0R
carprofen
FFL0D546HO
acetonitrile
Z072SB282N
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM