Immunohistochemical expression of osteopontin and collagens in choroid plexus of human brains.
calcification
choroid plexus
collagen
fibrosis
osteopontin
Journal
Neuropathology : official journal of the Japanese Society of Neuropathology
ISSN: 1440-1789
Titre abrégé: Neuropathology
Pays: Australia
ID NLM: 9606526
Informations de publication
Date de publication:
Apr 2022
Apr 2022
Historique:
revised:
25
10
2021
received:
02
09
2021
accepted:
29
10
2021
pubmed:
30
12
2021
medline:
14
4
2022
entrez:
29
12
2021
Statut:
ppublish
Résumé
Evidence showing the functional significance of the choroid plexus is accumulating. Although it is clinically well-known that calcification is frequently seen in the choroid plexus of aged human brains, it is unclear why calcification occurs in the aged choroid plexus and what exert effects on the calcification has. In this study, immunohistochemical localizations of collagens and other molecules related to fibrosis or calcification were investigated on the choroid plexus of autopsied human brains. Densely fibrous or calcified materials were located in the stroma just below the epithelial cells of the choroid plexus of all human brains examined. Immunoreactivity for collagen type I was identified in the stroma just below the epithelial cells, consistent with the densely fibrous or calcified area, whereas that for collagen type III was observed in almost all stroma other than the densely fibrous or calcified areas. Linear or membranous immunoreactivity for collagen type IV was intermittently localized on the epithelium-facing side of the materials, suggesting an injured basement membrane. In addition, clear immunoreactivity for osteopontin was localized on the epithelium-facing side of the fibrous or calcified materials as well as in the cytoplasm of epithelial cells. These findings indicate that collagen type I exists in contact with osteopontin in and around the densely fibrous or calcified materials in the choroid plexus. They suggest that the densely fibrous or calcified materials are deposited in the subepithelial stroma just below an injured basement membrane of epithelial cells via the collagen type I and osteopontin.
Identifiants
pubmed: 34964160
doi: 10.1111/neup.12791
pmc: PMC9546339
doi:
Substances chimiques
Collagen Type I
0
SPP1 protein, human
0
Osteopontin
106441-73-0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
117-125Subventions
Organisme : Japan Society for the Promotion of Science
ID : 17K08788
Organisme : Japan Society for the Promotion of Science
ID : 19K07508
Organisme : Japan Society for the Promotion of Science
ID : 20K16193
Organisme : Japan Society for the Promotion of Science
ID : 20K16550
Informations de copyright
© 2021 The Authors. Neuropathology published by John Wiley & Sons Australia, Ltd on behalf of Japanese Society of Neuropathology.
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