The polymorphism L412F in
Autophagy
COVID-19
HLA
L412F
TLR3
Journal
Autophagy
ISSN: 1554-8635
Titre abrégé: Autophagy
Pays: United States
ID NLM: 101265188
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
pubmed:
30
12
2021
medline:
20
7
2022
entrez:
29
12
2021
Statut:
ppublish
Résumé
The polymorphism L412F in TLR3 has been associated with several infectious diseases. However, the mechanism underlying this association is still unexplored. Here, we show that the L412F polymorphism in TLR3 is a marker of severity in COVID-19. This association increases in the sub-cohort of males. Impaired macroautophagy/autophagy and reduced TNF/TNFα production was demonstrated in HEK293 cells transfected with TLR3
Identifiants
pubmed: 34964709
doi: 10.1080/15548627.2021.1995152
pmc: PMC9298458
doi:
Substances chimiques
Biomarkers
0
TLR3 protein, human
0
Toll-Like Receptor 3
0
Hydroxychloroquine
4QWG6N8QKH
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1662-1672Subventions
Organisme : NIAID NIH HHS
ID : R01 AI158410
Pays : United States
Organisme : NIAID NIH HHS
ID : R56 AI151549
Pays : United States
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