Analysis of dental amalgam fillings on primary Sjögren's syndrome: A population-based case-control study in Taiwan.
Adolescent
Adult
Aged
Aged, 80 and over
Case-Control Studies
Databases, Factual
Dental Amalgam
/ adverse effects
Dental Caries
/ epidemiology
Dental Restoration, Permanent
/ adverse effects
Female
Humans
Male
Mercury
/ administration & dosage
Middle Aged
Retrospective Studies
Sjogren's Syndrome
/ epidemiology
Taiwan
/ epidemiology
Young Adult
Journal
Medicine
ISSN: 1536-5964
Titre abrégé: Medicine (Baltimore)
Pays: United States
ID NLM: 2985248R
Informations de publication
Date de publication:
24 Nov 2021
24 Nov 2021
Historique:
received:
14
10
2020
accepted:
11
11
2021
entrez:
29
12
2021
pubmed:
30
12
2021
medline:
15
2
2022
Statut:
ppublish
Résumé
Primary Sjören's syndrome (pSS) is an autoimmune disease characterized by the inflammatory infiltrate and progressive dysfunction of salivary glands. Dental amalgam with mercury has been raised the public concerns regarding its purported mercury toxicity from dental amalgam to possible systemic inflammatory and immune reactions.In this study, a nationwide population-based database was employed to investigate the association of amalgam filling (AMF) and the risk of pSS. A retrospective case-control study was sourced from the Taiwanese National Health Insurance Research Database (NHIRD) from 2000 to 2013. Case and control groups were matched by sex, age, urbanization level, monthly income, and comorbidities using the propensity score method with a 1:1 ratio. In this study, 5848 cases and 5848 controls were included.The results demonstrated no statistically significant differences between AMF and pSS (odds ratio [OR]: 0.974, 95% confidence interval [CI] = 0.904-1.049). In addition, pSS was also not associated with AMF for women (OR: 0.743, 95% CI = 0.552-1.000) and men (OR: 1.006, 95% CI = 0.670-1.509), respectively.Taken together, evidence demonstrated that the association of AMF and pSS was inconsistent from this robust register databank.
Identifiants
pubmed: 34964800
doi: 10.1097/MD.0000000000028031
pii: 00005792-202111240-00075
pmc: PMC8615304
doi:
Substances chimiques
Dental Amalgam
8049-85-2
Mercury
FXS1BY2PGL
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e28031Informations de copyright
Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.
Déclaration de conflit d'intérêts
The authors have no conflicts of interests to disclose.
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