Graphene Oxide Nanoparticels Interaction with Jurkat Cell Line in Cell-IQ System.
Cell-IQ
Jurkat
cell mass
graphene oxide nanoparticles
polyethylene glycol
viability
Journal
Doklady. Biochemistry and biophysics
ISSN: 1608-3091
Titre abrégé: Dokl Biochem Biophys
Pays: United States
ID NLM: 101126895
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
received:
13
05
2021
accepted:
07
09
2021
revised:
06
09
2021
entrez:
30
12
2021
pubmed:
31
12
2021
medline:
12
2
2022
Statut:
ppublish
Résumé
In recent years, materials based on graphene oxide (GO) have been actively studied for their use in biomedicine. The aim of our study was to investigate the increase in cell mass and viability of Jurkat tumor line T cells during 24 h of contact with GO nanoparticles in the Cell-IQ system of intravital observation. We used nanoparticles of different sizes coated with linear or branched polyethylene glycol (PEG) at concentrations of 5 and 25 μg/mL. It was shown for the first time that direct contact with GO nanoparticles reduced the growth in cell mass at the visualization points by more than twofold, regardless of nanoparticle size and concentration. Moreover, the number of live cells in the culture decreased by 5-9% after 24 h of monitoring. Thus, PEG-coated GO nanoparticles were found to suppress the proliferation and viability of Jurkat cell line T lymphocytes.
Identifiants
pubmed: 34966968
doi: 10.1134/S1607672921060089
pii: 10.1134/S1607672921060089
doi:
Substances chimiques
graphene oxide
0
Polyethylene Glycols
3WJQ0SDW1A
Graphite
7782-42-5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
438-443Informations de copyright
© 2021. Pleiades Publishing, Ltd.
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