Integrin-Mediated Targeted Cancer Therapy Using c(RGDyK)-Based Conjugates of Gemcitabine.

A549 Cells Animals Antimetabolites, Antineoplastic / chemistry Cell Proliferation Deoxycytidine / analogs & derivatives Humans Integrins / chemistry Lung Neoplasms / drug therapy Mice Mice, Inbred C57BL Peptides, Cyclic / chemistry Gemcitabine

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
13 01 2022
Historique:
pubmed: 31 12 2021
medline: 8 2 2022
entrez: 30 12 2021
Statut: ppublish

Résumé

c(RGDyK)-based conjugates of gemcitabine (GEM) with the carbonate and carbamate linkages in the 6-OH group of GEM were synthesized for the targeted delivery of GEM to integrin α

Identifiants

DOI: 10.1021/acs.jmedchem.1c01468 PMID: 34967607
pubmed: 34967607
doi: 10.1021/acs.jmedchem.1c01468
doi:

Substances chimiques

Antimetabolites, Antineoplastic 0
Integrins 0
Peptides, Cyclic 0
cyclic arginine-glycine-aspartic acid peptide 0
Deoxycytidine 0W860991D6
Gemcitabine 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

271-284

Auteurs

Theodora Chatzisideri (T)

Department of Chemistry, Aristotle University of Thessaloniki, University Campus, 54124 Thessaloniki, Greece.

George Leonidis (G)

Department of Chemistry, Aristotle University of Thessaloniki, University Campus, 54124 Thessaloniki, Greece.

Theodoros Karampelas (T)

Center of Clinical Research, Experimental Surgery and Translational Research, Division of Pharmacology-Pharmacotechnology, Biomedical Research Foundation, Academy of Athens, Soranou Ephessiou Street 4, Athens GR-11527, Greece.

Eleni Skavatsou (E)

Center of Clinical Research, Experimental Surgery and Translational Research, Division of Pharmacology-Pharmacotechnology, Biomedical Research Foundation, Academy of Athens, Soranou Ephessiou Street 4, Athens GR-11527, Greece.

Angeliki Velentza-Almpani (A)

Center of Clinical Research, Experimental Surgery and Translational Research, Division of Pharmacology-Pharmacotechnology, Biomedical Research Foundation, Academy of Athens, Soranou Ephessiou Street 4, Athens GR-11527, Greece.

Francesca Bianchini (F)

Department of Experimental and Clinical Biomedical Sciences, University of Florence, V.le GB Morgagni 50, 50134 Firenze, Italy.

Constantin Tamvakopoulos (C)

Center of Clinical Research, Experimental Surgery and Translational Research, Division of Pharmacology-Pharmacotechnology, Biomedical Research Foundation, Academy of Athens, Soranou Ephessiou Street 4, Athens GR-11527, Greece.
ORCID: 0000-0001-9627-4812

Vasiliki Sarli (V)

Department of Chemistry, Aristotle University of Thessaloniki, University Campus, 54124 Thessaloniki, Greece.
ORCID: 0000-0002-6128-8277

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Classifications MeSH

questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules A549 › Integrin-Mediated Targeted Cancer Therapy...
questionsmedicales.fr › Eucaryotes › Animaux › Integrin-Mediated Targeted Cancer Therapy...
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Noxas › Antimétabolites › Antimétabolites antinéoplasiques › Integrin-Mediated Targeted Cancer Therapy...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Integrin-Mediated Targeted Cancer Therapy...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléosides › Nucléosides pyrimidiques › Désoxycytidine › Integrin-Mediated Targeted Cancer Therapy...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Integrin-Mediated Targeted Cancer Therapy...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Intégrines › Integrin-Mediated Targeted Cancer Therapy...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Integrin-Mediated Targeted Cancer Therapy...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Integrin-Mediated Targeted Cancer Therapy...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Integrin-Mediated Targeted Cancer Therapy...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Peptides cycliques › Integrin-Mediated Targeted Cancer Therapy...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrimidines › Gemcitabine › Integrin-Mediated Targeted Cancer Therapy...