The Excited State Dynamics of a Mutagenic Cytidine Etheno Adduct Investigated by Combining Time-Resolved Spectroscopy and Quantum Mechanical Calculations.
Journal
The journal of physical chemistry letters
ISSN: 1948-7185
Titre abrégé: J Phys Chem Lett
Pays: United States
ID NLM: 101526034
Informations de publication
Date de publication:
13 Jan 2022
13 Jan 2022
Historique:
pubmed:
31
12
2021
medline:
1
3
2022
entrez:
30
12
2021
Statut:
ppublish
Résumé
Joint femtosecond fluorescence upconversion experiments and theoretical calculations provide a hitherto unattained degree of characterization and understanding of the mutagenic etheno adduct 3,N4-etheno-2'-deoxycytidine (εdC) excited state relaxation. This endogenously formed lesion is attracting great interest because of its ubiquity in human tissues and its highly mutagenic properties. The εdC fluorescence is modified with respect to that of the canonical base dC, with a 3-fold increased lifetime and quantum yield at neutral pH. This behavior is amplified upon protonation of the etheno ring (εdCH
Identifiants
pubmed: 34968067
doi: 10.1021/acs.jpclett.1c03534
pmc: PMC9135321
doi:
Substances chimiques
Mutagens
0
Cytidine
5CSZ8459RP
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
251-257Références
Phys Chem Chem Phys. 2020 Nov 18;22(44):25661-25668
pubmed: 33169771
Top Curr Chem. 2015;355:99-153
pubmed: 25273227
Top Curr Chem. 2015;355:1-32
pubmed: 25381199
Biochemistry. 1993 Nov 30;32(47):12793-801
pubmed: 8251500
J Phys Chem B. 2016 May 12;120(18):4232-42
pubmed: 27075054
Phys Chem Chem Phys. 2007 Jul 7;9(25):3206-9
pubmed: 17579729
Chem Rev. 2016 Mar 23;116(6):3540-93
pubmed: 26928320
J Phys Chem Lett. 2020 May 7;11(9):3203-3210
pubmed: 32251591
ACS Chem Biol. 2018 Mar 16;13(3):542-547
pubmed: 29300457
Chem Sci. 2020 Sep 22;11(41):11113-11123
pubmed: 34094354
Chem Res Toxicol. 2016 Dec 19;29(12):2008-2039
pubmed: 27989142
Angew Chem Int Ed Engl. 2013 Jun 17;52(25):6476-9
pubmed: 23657994
J Am Chem Soc. 1976 Nov 10;98(23):7408-14
pubmed: 977872
J Am Chem Soc. 2017 Jun 14;139(23):7780-7791
pubmed: 28513173
Phys Chem Chem Phys. 2016 Sep 21;18(35):24228-38
pubmed: 27539809
Carcinogenesis. 1996 Aug;17(8):1711-8
pubmed: 8761431
Phys Chem Chem Phys. 2010 May 21;12(19):5024-31
pubmed: 20445904
Biochemistry. 2009 Dec 8;48(48):11357-69
pubmed: 19883114
J Chem Theory Comput. 2020 Sep 8;16(9):5792-5808
pubmed: 32687360
Chem Commun (Camb). 2020 Apr 25;56(32):4404-4407
pubmed: 32239074
J Am Chem Soc. 2011 Mar 30;133(12):4212-5
pubmed: 21384855
Nucleic Acids Res. 1981 Jan 24;9(2):375-87
pubmed: 7010314
Phys Chem Chem Phys. 2015 Jul 15;17(29):19045-57
pubmed: 26126728
J Phys Chem A. 2007 Sep 6;111(35):8708-16
pubmed: 17696511
Photochem Photobiol Sci. 2003 Apr;2(4):362-4
pubmed: 12760530
J Am Chem Soc. 2014 Aug 6;136(31):10838-41
pubmed: 25050452
Signal Transduct Target Ther. 2017 Jun 09;2:17021
pubmed: 29263920
Biochemistry. 1972 Sep 12;11(19):3499-506
pubmed: 4340904
J Chem Theory Comput. 2013 Apr 9;9(4):2072-82
pubmed: 26583553
Free Radic Biol Med. 2017 Jun;107:77-89
pubmed: 27908783
J Chem Phys. 2017 Jun 28;146(24):244308
pubmed: 28668059
Chem Res Toxicol. 1995 Mar;8(2):278-83
pubmed: 7766812
Chem Rev. 2004 Apr;104(4):1977-2019
pubmed: 15080719
Top Curr Chem. 2015;355:57-97
pubmed: 24264958
Carcinogenesis. 1996 Oct;17(10):2105-11
pubmed: 8895475