Parathyroid hormone signaling in mature osteoblasts/osteocytes protects mice from age-related bone loss.
Animals
Bone Diseases, Metabolic
/ pathology
Bone Resorption
/ metabolism
Bone and Bones
/ cytology
Homeostasis
/ drug effects
Mice
Mice, Knockout
Osteoblasts
/ cytology
Osteoclasts
/ cytology
Osteocytes
/ drug effects
Osteoporosis
/ metabolism
Parathyroid Hormone
/ pharmacology
Receptor, Parathyroid Hormone, Type 1
/ metabolism
Signal Transduction
/ drug effects
aging
osteocyte
osteoporosis
oxidative stress
parathyroid hormone
Journal
Aging
ISSN: 1945-4589
Titre abrégé: Aging (Albany NY)
Pays: United States
ID NLM: 101508617
Informations de publication
Date de publication:
30 12 2021
30 12 2021
Historique:
received:
20
09
2021
accepted:
30
11
2021
pubmed:
31
12
2021
medline:
1
2
2022
entrez:
30
12
2021
Statut:
ppublish
Résumé
Aging is accompanied by osteopenia, characterized by reduced bone formation and increased bone resorption. Osteocytes, the terminally differentiated osteoblasts, are regulators of bone homeostasis, and parathyroid hormone (PTH) receptor (PPR) signaling in mature osteoblasts/osteocytes is essential for PTH-driven anabolic and catabolic skeletal responses. However, the role of PPR signaling in those cells during aging has not been investigated. The aim of this study was to analyze the role of PTH signaling in mature osteoblasts/osteocytes during aging. Mice lacking PPR in osteocyte (Dmp1-PPR
Identifiants
pubmed: 34968192
pii: 203808
doi: 10.18632/aging.203808
pmc: PMC8751595
doi:
Substances chimiques
Parathyroid Hormone
0
Receptor, Parathyroid Hormone, Type 1
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
25607-25642Subventions
Organisme : NIH HHS
ID : S10 OD021652
Pays : United States
Organisme : NIAMS NIH HHS
ID : UH3 AR059655
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR060221
Pays : United States
Organisme : NIAMS NIH HHS
ID : UH2 AR059655
Pays : United States
Organisme : NIAMS NIH HHS
ID : P30 AR066261
Pays : United States
Organisme : NIDDK NIH HHS
ID : R56 DK079161
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK079161
Pays : United States
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