Leveraging artificial intelligence to advance the understanding of chemical neurotoxicity.

Artificial intelligence Commentary Neurotoxicity

Journal

Neurotoxicology
ISSN: 1872-9711
Titre abrégé: Neurotoxicology
Pays: Netherlands
ID NLM: 7905589

Informations de publication

Date de publication:
03 2022
Historique:
received: 06 12 2021
accepted: 25 12 2021
pubmed: 31 12 2021
medline: 8 4 2022
entrez: 30 12 2021
Statut: ppublish

Résumé

Neurotoxicology is a specialty that aims to understand and explain the impact of chemicals, xenobiotics and physical conditions on nervous system function throughout the life span. Herein, we point to the need for integration of novel translational bioinformatics and chemo-informatics approaches, such as machine learning (ML) and artificial intelligence (AI) to the discipline. Specifically, we advance the notion that AI and ML will be helpful in identifying neurotoxic signatures, provide reliable data in predicting neurotoxicity in the context of genetic variability, and improve the understanding of neurotoxic outcomes associated with exposures to mixtures, to name a few.

Identifiants

pubmed: 34968636
pii: S0161-813X(21)00169-8
doi: 10.1016/j.neuro.2021.12.007
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

9-11

Informations de copyright

Copyright © 2021 Elsevier B.V. All rights reserved.

Auteurs

Michael Aschner (M)

Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, United States. Electronic address: michael.aschner@einsteinmed.org.

Robin Mesnage (R)

Gene Expression and Therapy Group, King's College London, Faculty of Life Sciences & Medicine, Department of Medical and Molecular Genetics, Guy's Hospital, London, SE1 9RT, UK.

Anca Oana Docea (AO)

Department of Toxicology, University of Medicine and Pharmacy of Craiova, 200349, Craiova, Romania.

Monica Maria Bastos Paoliello (MMB)

Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, United States.

Aristides Tsatsakis (A)

Department of Forensic Sciences and Toxicology, Faculty of Medicine, University of Crete, 71003, Heraklion, Greece; Department of Analytical and Forensic Medical Toxicology, Sechenov University, 119991, Moscow, Russia.

Georgios Giannakakis (G)

Hybrid Molecular Imaging Unit (HMIU), Foundation for Research and Technology Hellas (FORTH), Greece.

Georgios Z Papadakis (GZ)

Hybrid Molecular Imaging Unit (HMIU), Foundation for Research and Technology Hellas (FORTH), Greece.

Silvio Roberto Vinceti (SR)

University of Modena and Reggio Emilia: Universita degli Studi di Modena e Reggio Emilia, Italy.

Abel Santamaria (A)

Laboratorio de Aminoácidos Excitadores, Instituto Nacional de Neurología y Neurocirugía, S.S.A., Mexico City 14269, Mexico.

Anatoly V Skalny (AV)

World-Class Research Center "Digital Biodesign and Personalized Healthcare", IM Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia; K.G. Razumovsky Moscow State University of Technologies and Management, Moscow, Russia.

Alexey A Tinkov (AA)

IM Sechenov First Moscow State Medical University (Sechenov University), Moscow, 119146, Russia; Yaroslavl State University, Sovetskaya Str. 14, Yaroslavl, 150000, Russia.

Articles similaires

Humans Artificial Intelligence COVID-19 SARS-CoV-2 Pandemics
Humans Algorithms Software Artificial Intelligence Computer Simulation
Humans Artificial Intelligence Neoplasms Prognosis Image Processing, Computer-Assisted

Classifications MeSH