Predictors of Virological Failure Among People Living with HIV Switching from an Effective First-Line Antiretroviral Regimen.
optimization
resistance-associated mutations
second-line antiretroviral therapy
Journal
AIDS research and human retroviruses
ISSN: 1931-8405
Titre abrégé: AIDS Res Hum Retroviruses
Pays: United States
ID NLM: 8709376
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
pubmed:
1
1
2022
medline:
10
6
2022
entrez:
31
12
2021
Statut:
ppublish
Résumé
Aim of this study was to assess the predictors of virological failure (VF) among patients living with HIV (PLWHIV) switching from an effective first-line antiretroviral therapy (ART) regimen, and to evaluate the emergence of resistance-associated mutations. All adult patients enrolled in the Antiviral Response Cohort Analysis cohort who started ART after 2010, with at least 6 months of virological suppression (VS) before ART switch and with an available genotypic resistance test (GRT) at baseline were included. Thirty-two patients out of the 607 PLWHIV included (5.3%) experienced VF after a median of 11 months from ART switch. Younger age (adjusted Hazard Ratio [aHR] 0.96, 95% confidence interval [CI] 0.92-0.99,
Identifiants
pubmed: 34969260
doi: 10.1089/AID.2021.0016
doi:
Substances chimiques
Anti-HIV Agents
0
Anti-Retroviral Agents
0
Protease Inhibitors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM