The Effect of Smoking on Progression from Ductal Carcinoma
Adult
Aged
Carcinoma, Ductal, Breast
/ chemically induced
Carcinoma, Intraductal, Noninfiltrating
/ diagnosis
Disease Progression
Female
Humans
Lymphatic Metastasis
/ diagnosis
Middle Aged
Neoplasm Invasiveness
/ diagnostic imaging
Retrospective Studies
Sentinel Lymph Node Biopsy
/ methods
Smoking
/ adverse effects
Breast cancer
biopsy
ductal carcinoma in situ
invasive ductal carcinoma
smoking
Journal
Anticancer research
ISSN: 1791-7530
Titre abrégé: Anticancer Res
Pays: Greece
ID NLM: 8102988
Informations de publication
Date de publication:
Jan 2022
Jan 2022
Historique:
received:
30
10
2021
revised:
19
11
2021
accepted:
22
11
2021
entrez:
31
12
2021
pubmed:
1
1
2022
medline:
14
1
2022
Statut:
ppublish
Résumé
If ductal carcinoma in situ (DCIS) is diagnosed by needle biopsy, invasion is often found by removing the entire tumor and performing pathological examination. Smoking is a risk factor for carcinogenesis in breast cancer. We examined the correlation between the risk of invasion found by postoperative pathology and smoking history in patients diagnosed with DCIS by preoperative biopsy. We examined 128 patients who were diagnosed with DCIS by preoperative biopsy. Multivariate analysis was performed on the risk factors for invasion diagnosed by postoperative pathological examination in all cases diagnosed with DCIS by preoperative biopsy. Multivariate analysis was performed on the risk factors for invasion diagnosed by postoperative pathological examination in all cases diagnosed with DCIS by preoperative biopsy. Number of pack-years was not an independent factor (p=0.349, OR=0.329), but current-smoker status (p=0.006, OR=not calculable) was an independent factor with VAB (p=0.018, OR=0.327). Tobacco components may have an influence on the progression from DCIS to invasive ductal carcinoma.
Sections du résumé
BACKGROUND/AIM
OBJECTIVE
If ductal carcinoma in situ (DCIS) is diagnosed by needle biopsy, invasion is often found by removing the entire tumor and performing pathological examination. Smoking is a risk factor for carcinogenesis in breast cancer. We examined the correlation between the risk of invasion found by postoperative pathology and smoking history in patients diagnosed with DCIS by preoperative biopsy.
PATIENTS AND METHODS
METHODS
We examined 128 patients who were diagnosed with DCIS by preoperative biopsy. Multivariate analysis was performed on the risk factors for invasion diagnosed by postoperative pathological examination in all cases diagnosed with DCIS by preoperative biopsy.
RESULTS
RESULTS
Multivariate analysis was performed on the risk factors for invasion diagnosed by postoperative pathological examination in all cases diagnosed with DCIS by preoperative biopsy. Number of pack-years was not an independent factor (p=0.349, OR=0.329), but current-smoker status (p=0.006, OR=not calculable) was an independent factor with VAB (p=0.018, OR=0.327).
CONCLUSION
CONCLUSIONS
Tobacco components may have an influence on the progression from DCIS to invasive ductal carcinoma.
Identifiants
pubmed: 34969739
pii: 42/1/311
doi: 10.21873/anticanres.15487
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
311-320Informations de copyright
Copyright © 2022 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.