Japan Society of Clinical Oncology Clinical Practice Guidelines 2017 for fertility preservation in childhood, adolescent, and young adult cancer patients: part 1.


Journal

International journal of clinical oncology
ISSN: 1437-7772
Titre abrégé: Int J Clin Oncol
Pays: Japan
ID NLM: 9616295

Informations de publication

Date de publication:
Feb 2022
Historique:
received: 25 10 2021
accepted: 07 11 2021
pubmed: 2 1 2022
medline: 9 2 2022
entrez: 1 1 2022
Statut: ppublish

Résumé

In 2017, the Japan Society of Clinical Oncology (JSCO) published the JSCO Clinical Practice Guidelines 2017 for Fertility Preservation in Childhood, Adolescent, and Young Adult Cancer Patients. These were the first Japanese guidelines to address issues of oncofertility. In this field of medicine, sustained close cooperation between oncologists and reproductive specialists is essential from the diagnosis of cancer until many years after completion of cancer treatment. These JSCO guidelines were intended to guide multidisciplinary medical staff in considering the availability of fertility preservation options and to help them decide whether to provide fertility preservation to childhood, adolescent, and young adult cancer patients before treatment starts, with the ultimate goal of improving patient survivorship. The guidelines are presented as Parts 1 and 2. This article (Part 1) summarizes the goals of the guidelines and the methods used to develop them and provides an overview of fertility preservation across all oncology areas. It includes general remarks on the basic concepts surrounding fertility preservation and explanations of the impacts of cancer treatment on gonadal function by sex and treatment modality and of the options for protecting/preserving gonadal function and makes recommendations based on 4 clinical questions. Part 2 of these guidelines provides specific recommendations on fertility preservation in 8 types of cancer (gynecologic, breast, urologic, pediatric, hematologic, bone and soft tissue, brain, and digestive).

Identifiants

pubmed: 34973107
doi: 10.1007/s10147-021-02081-w
pii: 10.1007/s10147-021-02081-w
pmc: PMC8816532
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

265-280

Informations de copyright

© 2021. The Author(s).

Références

ASCO Recommendations on Fertility Preservation in Cancer Patients (2006) J Clin Oncol 24:2917–2931
Loren AW, Mangu PB, Beck LN et al (2013) Fertility preservation for patients with cancer: American Society of Clinical Oncology clinical practice guideline update. J Clin Oncol 31:2500–2510
pubmed: 23715580 pmcid: 5321083
von Wolff M, Montag M, Dittrich R et al (2011) Fertility preservation in women–a practical guide to preservation techniques and therapeutic strategies in breast cancer, Hodgkin’s lymphoma and borderline ovarian tumours by the fertility preservation network FertiPROTEKT. Arch Gynecol Obstet 284:427–435
ISFP Practice Committee, Kim SS, Donnez J, et. (2012) Recommendations for fertility preservation in patients with lymphoma, leukemia, and breast cancer. J Assist Reprod Genet 29:465–468
Schmidt KT, Andersen CY; ISFP Practice Committee (2012) Recommendations for fertility preservation in patients with lymphomas. J Assist Reprod Genet 29:473–477
Klemp JR, Kim SS; ISFP Practice Committee (2012) Fertility preservation in young women with breast cancer. J Assist Reprod Genet 29:469–472
Iwase A, Hirokawa W, Goto M et al (2010) Serum anti-Müllerian hormone level is a useful marker for evaluating the impact of laparoscopic cystectomy on ovarian reserve. Fertil Steril 94:2846–2849
pubmed: 20630505
Ben-Aharon I, Shalgi R (2012) What lies behind chemotherapy-induced ovarian toxicity? Reproduction 144:153–163
pubmed: 22653316
Koyama H, Wada T, Nishizawa J et al (1977) Cyclophosphamide-induced ovarian failure and its therapeutic significance in patients with breast cancer. Cancer 39:1403–1409
pubmed: 851940
Rose DP, Davis TE (1977) Ovarian function in patients receiving adjuvant chemotherapy for breast cancer. Lancet 1:1174–1176
pubmed: 68275
Warne GL, Fairley KF, Hobbs JB et al (1973) Cyclophosphamide-induced ovarian failure. N Engl J Med 289:1159–1162
pubmed: 4754963
Bokemeyer C, Schmoll HJ, van Rhee J et al (1994) Long-term gonadal toxicity after therapy for Hodgkin’s and non-Hodgkin’s lymphoma. Ann Hematol 68:105–110
pubmed: 8167175
Byrne J, Fears TR, Gail MH et al (1992) Early menopause in long-term survivors of cancer during adolescence. Am J Obstet Gynecol 166:788–793
pubmed: 1550144
Green DM, Kawashima T, Stovall M et al (2009) Fertility of female survivors of childhood cancer: a report from the childhood cancer survivor study. J Clin Oncol 27:2677–2685
pubmed: 19364965 pmcid: 2690392
Wallace WH, Thomson AB, Kelsey TW (2003) The radiosensitivity of the human oocyte. Hum Reprod 18:117–121
pubmed: 12525451
Wo JY, Viswanathan AN (2009) Impact of radiotherapy on fertility, pregnancy, and neonatal outcomes in female cancer patients. Int J Radiat Oncol Biol Phys 73:1304–1312
pubmed: 19306747 pmcid: 2865903
Wallace WH, Thomson AB, Saran F et al (2005) Predicting age of ovarian failure after radiation to a field that includes the ovaries. Int J Radiat Oncol Biol Phys 62:738–744
pubmed: 15936554
Rodriguez-Wallberg KA, Oktay K (2010) Fertility preservation medicine: options for young adults and children with cancer. J Pediatr Hematol Oncol 32:390–396
pubmed: 20502358
Rappaport R, Brauner R, Czernichow P et al (1982) Effect of hypothalamic and pituitary irradiation on pubertal development in children with cranial tumors. J Clin Endocrinol Metab 54:1164–1168
pubmed: 6804477
Huddart RA, Norman A, Moynihan C et al (2005) Fertility, gonadal and sexual function in survivors of testicular cancer. Br J Cancer 93:200–207
pubmed: 15999104 pmcid: 2361550
Howell SJ, Radford JA, Ryder WD et al (1999) Testicular function after cytotoxic chemotherapy: evidence of Leydig cell insufficiency. J Clin Oncol 17:1493–1498
pubmed: 10334536
Howell SJ, Shalet SM (2001) Testicular function following chemotherapy. Hum Reprod Update 7:363–369
pubmed: 11476348
Green DM, Liu W, Kutteh WH et al (2014) Cumulative alkylating agent exposure and semen parameters in adult survivors of childhood cancer: a report from the St Jude Lifetime Cohort Study. Lancet Oncol 15:1215–1223
pubmed: 25239573 pmcid: 4192599
Thomson AB, Campbell AJ, Irvine DC et al (2002) Semen quality and spermatozoal DNA integrity in survivors of childhood cancer: a case-control study. Lancet 360:361–367
pubmed: 12241775
Aubier F, Flamant F, Brauner R et al (1989) Male gonadal function after chemotherapy for solid tumors in childhood. J Clin Oncol 7:304–309
pubmed: 2493074
Williams D, Crofton PM, Levitt G (2008) Does isosfamide affect gonadal function? Pediatr Blood Cancer 50:347–351
pubmed: 17973323
Lampe H, Horwich A, Norman A et al (1997) Fertility after chemotherapy for testicular germ cell cancers. J Clin Oncol 15:239–245
pubmed: 8996148
Green DM, Kawashima T, Stovall M et al (2010) Fertility of male survivors of childhood cancer: a report from the childhood cancer survivor study. J Clin Oncol 28:332–339
pubmed: 19949008
Shalet SM, Tsatsoulis A, Whitehead E et al (1989) Vulnerability of the human Leydig cell to radiation damage is dependent upon age. J Endocrinol 120:161–165
pubmed: 2493061
Ash P (1980) The influence of radiation on fertility in man. Br J Radiol 53:271–278
pubmed: 6991051
Shalet SM (1993) Effect of irradiation treatment on gonadal function in men treated for germ cell cancer. Eur Urol 23:148–151
pubmed: 8386642
Kinsella TJ, Trivette G, Rowland J et al (1989) Long-term follow-up of testicular function following radiation therapy for early-stage Hodgkin’s disease. J Clin Oncol 7:718–724
pubmed: 2497228
Schmiegelow M, Lassen S, Poulsen HS et al (2001) Gonadal status in male survivors following childhood brain tumors. J Clin Endocrinol Metab 86:2446–2452
pubmed: 11397837
Gogas H, Ioannovich J, Dafni U et al (2006) Prognostic significance of autoimmunity during treatment of melanoma with interferon. N Engl J Med 354:709–718
pubmed: 16481638
Carella C, Mazziotti G, Amato G et al (2004) Clinical review 169: Interferon-alpha-related thyroid disease: pathophysiological, epidemiological, and clinical aspects. J Clin Endocrinol Metab 89:3656–3661
pubmed: 15292282
Funakoshi T, Shimada YJ (2013) Risk of hypothyroidism in patients with cancer treated with sunitinib: a systematic review and meta-analysis. Acta Oncol 52:691–702
pubmed: 23282114
Irtan S, Orbach D, Helfre S et al (2013) Ovarian transposition in prepubescent and adolescent girls with cancer. Lancet Oncol 14:e601–e608
pubmed: 24275133
Hwang JH, Yoo HJ, Park SH et al (2012) Association between the location of transposed ovary and ovarian function in patients with uterine cervical cancer treated with (postoperative or primary) pelvic radiotherapy. Fertil Steril 97:1387–1393
pubmed: 22464082
Arango O, Bielsa O, Lorente JA et al (2002) Hemiscrotectomy with contralateral testicular transposition for scrotal cancer. J Urol 168:1406–1407
pubmed: 12352404
Trost LW, Brannigan RE (2012) Oncofertility and the male cancer patient. Curr Treat Options Oncol 13:146–160
pubmed: 22528369
Ethics Committee of American Society for Reproductive Medicine (2013) Fertility preservation and reproduction in patients facing gonadotoxic therapies: a committee opinion. Fertil Steril 100:1224–1231
Linkeviciute A, Boniolo G, Chiavari L et al (2014) Fertility preservation in cancer patients: the global framework. Cancer Treat Rev 40:1019–1027
pubmed: 24953980
Anderson RA, Mitchell RT, Kelsey TW et al (2015) Cancer treatment and gonadal function: experimental and established strategies for fertility preservation in children and young adults. Lancet Diabetes Endocrinol 3:556–567
pubmed: 25873571
Coccia PF, Pappo AS, Altman J et al (2014) Adolescent and young adult oncology, ver. 2 2014. J Natl Compr Canc Netw 12:21–32
pubmed: 24453290
Coleman SL, Grothey A (2011) Should oncologists routinely discuss fertility preservation with cancer patients of childbearing age? Mayo Clin Proc 86:6–7
pubmed: 21193648 pmcid: 3012626
Johnson RH, Kroon L (2013) Optimizing fertility preservation practices for adolescent and young adult cancer patients. J Natl Compr Canc Netw 11:71–77
pubmed: 23307983
Salih SM, Elsarrag SZ, Prange E et al (2015) Evidence to incorporate inclusive reproductive health measures in guidelines for childhood and adolescent cancer survivors. J Pediatr Adolesc Gynecol 28:95–101
pubmed: 25850590
Collins IM, Fay L, Kennedy MJ (2011) Strategies for fertility preservation after chemotherapy: awareness among Irish cancer specialists. Ir Med J 104:6–9
pubmed: 21391329
Shimizu C, Bando H, Kato T et al (2013) Physicians’ knowledge, attitude, and behavior regarding fertility issues for young breast cancer patients: a national survey for breast care specialists. Breast Cancer 20:230–240
pubmed: 22271066
Dursun P, Dogˇan NU, Ayhan A et al (2014) Oncofertility for gynecologic and non-gynecologic cancers: fertility sparing in young women of reproductive age. Crit Rev Oncol Hematol 92:258–267
pubmed: 25090914
Furui T, Takenaka M, Makino H et al (2016) An evaluation of the Gifu Model in a trial for a new regional oncofertility network in Japan, focusing on its necessity and effects. Reprod Med Biol 15:107–113
pubmed: 29259426
Practice Committee of American Society for Reproductive Medicine (2014) Ovarian tissue cryopreservation: a committee opinion. Fertil Steril 101:1237–1243
Wallace WH, Kelsey TW, Anderson RA (2016) Fertility preservation in pre-pubertal girls with cancer: the role of ovarian tissue cryopreservation. Fertil Steril 105:6–12
pubmed: 26674557
De Vos M, Smitz J, Woodruff TK (2014) Fertility preservation in women with cancer. Lancet 384:1302–1310
pubmed: 25283571 pmcid: 4270060
Tournaye H, Dohle GR, Barratt CL (2014) Fertility preservation in men with cancer. Lancet 384:1295–1301
Lambertini M, Del Mastro L, Pescio MC et al (2016) Cancer and fertility preservation: international recommendations from an expert meeting. BMC Med 14:1
pubmed: 26728489 pmcid: 4700580
Oktay K, Turan V, Bedoschi G et al (2015) Fertility preservation success subsequent to concurrent aromatase inhibitor treatment and ovarian stimulation in women with breast cancer. J Clin Oncol 33:2424–2429
pubmed: 26101247 pmcid: 4507464
Kim J, Turan V, Oktay K (2016) Long-term safety of letrozone and gonadotropin stimulation for fertility preservation in women with breast cancer. J Clin Endocrinol Metab 101:1364–1371
pubmed: 26751194 pmcid: 4880171
Practice Committees of American Society for Reproductive Medicine and the Society for Assisted Reproductive Technology (2013) Mature oocyte cryopreservation: a guideline. Fertil Steril 99:37–43
National Institute for Health and Clinical Excellence: Fertility-Assessment and treatment for people with fertility problems. 2013. http://www.nice.org.uk/guidance/cg156
Glujovsky D, Riestra B, Sueldo C et al (2014) Vitrification versus slow freezing for women undergoing oocyte cryopreservation. Cochrane Database Syst Rev 9:CD010047
Cobo A, Diaz C (2011) Clinical application of oocyte vitrification: a systematic review and meta-analysis of randomized controlled trials. Fertil Steril 96:277–285
pubmed: 21718983
Cobo A, Serra V, Garrido N et al (2014) Obstetric and perinatal outcome of babies born from vitrified oocytes. Fertil Steril 102:1006–15. e4
pubmed: 25064408
Donnez J, Dolmans MM (2015) Ovarian cortex transplantation: 60 reported live births brings the success and worldwide expansion of the technique towards routine clinical practice. J Assist Reprod Genet 32:1167–1170
pubmed: 26210678 pmcid: 4554373
Suzuki N, Yoshioka N, Takae S et al (2015) Successful fertility preservation following ovarian tissue vitrification in patients with primary ovarian insufficiency. Hum Reprod 30:608–615
pubmed: 25567618
Stoop D, Cobo A, Silber S (2014) Fertility preservation for age-related fertility decline. Lancet 384:1311–1319
pubmed: 25283572
Stern CJ, Gook D, Hale LG et al (2014) Delivery of twins following heterotopic grafting of frozen-thawed ovarian tissue. Hum Reprod 29:1828
pubmed: 24871346
Rosendahl M, Greve T, Andersen CY (2013) The safety of transplanting cryopreserved ovarian tissue in cancer patients: a review of the literature. J Assist Reprod Genet 30:11–24
pubmed: 23263841
Koren G, Carey N, Gagnon R et al (2013) Cancer chemotherapy and pregnancy. J Obstet Gynaecol Can 35:263–280
pubmed: 23470115
Cardoso F, Loibl S, Pagani O et al (2012) The European society of breast cancer specialists recommendations for the management of young women with breast cancer. Eur J Cancer 48:3355–3377
pubmed: 23116682
Barekati Z, Gourabi H, Valojerdi MR et al (2008) Previous maternal chemotherapy by cyclophosphamide (Cp) causes numerical chromosome abnormalities in preimplantation mouse embryos. Reprod Toxicol 26:278–281
pubmed: 18930809
Landa A, Kuller J, Rhee E (2015) Perinatal considerations in women with previous diagnosis of cancer. Obstet Gynecol Surv 70:765–772
pubmed: 26676147
Levine J, Canada A, Stern CJ (2010) Fertility preservation in adolescents and young adults with cancer. J Clin Oncol 28:4831–4841
pubmed: 20458029
Ferrari S, Paffoni A, Filippi F et al (2016) Sperm cryopreservation and reproductive outcome in male cancer patients: a systematic review. Reprod Biomed Online 33:29–38
pubmed: 27156003
van Casteren NJ, van Santbrink EJ, van Inzen W et al (2008) Use rate and assisted reproduction technologies outcome of cryopreserved semen from 629 cancer patients. Fertil Steril 90:2245–2250
pubmed: 18191846
Agarwal A, Ranganathan P, Kattal N et al (2004) Fertility after cancer: a prospective review of assisted reproductive outcome with banked semen specimens. Fertil Steril 81:342–348
pubmed: 14967371
Picton HM, Wyns C, Anderson RA et al (2015) A European perspective on testicular tissue cryopreservation for fertility preservation in prepubertal and adolescent boys. Hum Reprod 30:2463–2475
pubmed: 26358785
Saito K, Kinoshita Y, Yumura Y et al (1998) Successful pregnancy with sperm retrieved from the bladder after the introduction of a low-electrolyte solution for retrograde ejaculation. Fertil Steril 69:1149–1151
pubmed: 9627308
Chow EJ, Kamineni A, Daling JR et al (2009) Reproductive outcomes in male childhood cancer survivors: a linked cancer-birth registry analysis. Arch Pediatr Adolesc Med 163:887–894
pubmed: 19805706 pmcid: 2758644
Shin T, Kobayashi T, Shimomura Y et al (2016) Microdissection testicular sperm extraction in Japanese patients with persistent azoospermia after chemotherapy. Int J Clin Oncol 21:1167–1171
pubmed: 27306218
Rohayem J, Hauffa BP, Zacharin M et al (2017) Testicular growth and spermatogenesis: new goals for pubertal hormone replacement in boys with hypogonadotropic hypogonadism?—a multicentre prospective study of hCG/rFSH treatment outcomes during adolescence. Clin Endocrinol (Oxf) 86:75–87
Magelssen H, Brydøy M, Fosså SD (2006) The effects of cancer and cancer treatments on male reproductive function. Nat Clin Pract Urol 3:312–322
pubmed: 16763643
Amano T (2013) Ejaculation dysfunction, especially intra-vaginal ejaculation insufficiency, and male infertility. Jpn J Urol Surg 26:1357–1362 (in Japanese)
Stewart J, Breslin WJ, Beyer BK et al (2016) Birth control in clinical trials: industry survey of current use practices, governance, and monitoring. Ther Innov Regul Sci 50:155–168
pubmed: 27042398
Assessment of male-mediated developmental risk for pharmaceuticals guidance for industry. U.S. department of health and human services food and drug administration center for drug evaluation and research (CDER). http://www.fda.gov/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/default.htm
Mork ME, You YN, Ying J et al (2015) High prevalence of hereditary cancer syndromes in adolescents and young adults with colorectal cancer. J Clin Oncol 33:3544–3549
pubmed: 26195711 pmcid: 4979241
Shapira M, Raanani H, Meirow D (2015) IVF for fertility preservation in breast cancer patients–efficacy and safety issues. J Assist Reprod Genet 32:1171–1178
pubmed: 26126877 pmcid: 4554381
Daly MB, Pilarski R, Berry M et al (2017) NCCN guidelines insights: genetic/familial high-risk assessment: breast and ovarian, version 2.2017. J Natl Compr Canc Netw 15:9–20
pubmed: 28040716

Auteurs

Miyuki Harada (M)

Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo, Tokyo, 113-8655, Japan.

Fuminori Kimura (F)

Department of Obstetrics and Gynecology, Shiga University of Medical Science, Seta Tsukinowa-Cho Otsu, Shiga, 520-2192, Japan.

Yasushi Takai (Y)

Department of Obstetrics and Gynecology Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe City, Saitama, 350-3550, Japan.

Takeshi Nakajima (T)

Department of Endoscopy, Gastrointestinal Endoscopy Division, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

Kimio Ushijima (K)

Department of Obstetrics and Gynecology, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan.

Hiroaki Kobayashi (H)

Department of Obstetrics and Gynecology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan.

Toyomi Satoh (T)

Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tsukuba, Tennoudai, Tsukuba, Ibaraki, 305-8575, Japan.

Akiko Tozawa (A)

Department of Obstetrics and Gynecology, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae, Kawasaki, Kanagawa, 216-8511, Japan.

Kohei Sugimoto (K)

International Center for Reproductive Medicine, Dokkyo Medical University Saitama Medical Center, 2-1-50 Minamikoshigaya, Koshigaya, Saitama, 343-8555, Japan.

Shigehira Saji (S)

Department of Medical Oncology, Fukushima Medical University, 1 Hikarigaoka, Fukushima-city, Fukushima, 960-1295, Japan.

Chikako Shimizu (C)

Department of Breast and Medical Oncology, Comprehensive Cancer Center, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo, 162-8655, Japan.

Kyoko Akiyama (K)

Department of Breast and Endocrine Surgery, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae, Kawasaki, Kanagawa, 216-8511, Japan.

Hiroko Bando (H)

Department of Breast and Endocrine Surgery, Faculty of Medicine, University of Tsukuba, Tennoudai, Tsukuba, Ibaraki, 305-8575, Japan.

Akira Kuwahara (A)

Ladies Clinic Cosmos Kochi, 6-27, Sugiiru, Kochi, Kochi, 780-0082, Japan.

Tatsuro Furui (T)

Department of Obstetrics and Gynecology, Gifu University Graduate School of Medicine, 1-1, Yanagido, Gifu City, Gifu, 501-1194, Japan.

Hiroshi Okada (H)

International Center for Reproductive Medicine, Dokkyo Medical University Saitama Medical Center, 2-1-50 Minamikoshigaya, Koshigaya, Saitama, 343-8555, Japan.

Koji Kawai (K)

Department of Urology, International University of Health and Welfare, 852, Hatakeda Narita, Chiba, 286-0124, Japan.

Nobuo Shinohara (N)

Department of Renal and Genitourinary Surgery, Hokkaido University Graduate School of Medicine, Kita 15Nishi 7, Kita-ku, Sapporo, Hokkaido, 060-8638, Japan.

Koichi Nagao (K)

Department of Urology, Toho University Faculty of Medicine, 6-11-1, Omori-Nishi, Ota-ku, Tokyo, 143-8541, Japan.

Michio Kitajima (M)

Department of Obstetrics and Gynecology, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, Nagasaki, 852-8523, Japan.

Souichi Suenobu (S)

Division of General Pediatrics and Emergency Medicine, Department of Pediatrics, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama, Yufu, Oita, 879-5593, Japan.

Toshinori Soejima (T)

Department of Radiation Oncology, Kobe Proton Center, 1-6-8, Minatojima-minamimachi, Chuo-ku, Kobe City, Hyogo, 650-0047, Japan.

Mitsuru Miyachi (M)

Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.

Yoko Miyoshi (Y)

Department of Health and Nutrition, Faculty of Health and Nutrition, Osaka Shoin Women's University, 4-2-26 Hishiya-nishi, Higashi-Osaka, Osaka, 577-8550, Japan.

Akihiro Yoneda (A)

Division of Pediatric Surgical Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

Akihito Horie (A)

Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shogoin, Sakyoku, Kyoto, 606-8507, Japan.

Yasushi Ishida (Y)

Pediatric Medical Center, Ehime Prefectural Central Hospital, 83 Kasuga-machi, Matsuyama-city, Ehime, 790-0024, Japan.

Noriko Usui (N)

Division of Clinical Oncology and Hematology, Department of Internal Medicine, The Jikei University School of Medicine, 3-19-18 Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan.

Yoshinobu Kanda (Y)

Division of Hematology, Department of Medicine, Jichi Medical University, 1-847 Amanuma, Omiya-ku, Saitama-city, Saitama, 330-8503, Japan.

Nobuharu Fujii (N)

Division of Transfusion, Okayama University Hospital, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.

Makoto Endo (M)

Department of Orthopaedic Surgery, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka, 812-8582, Japan.

Robert Nakayama (R)

Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan.

Manabu Hoshi (M)

Department of Orthopedic Surgery, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-Machi, Abeno-Ku, Osaka, 545-8585, Japan.

Tsukasa Yonemoto (T)

Division of Orthopedic Surgery, Chiba Cancer Center, 666-2 Nitona-cho, Chuo-ku, Chiba, 260-8717, Japan.

Chikako Kiyotani (C)

Children's Cancer Center, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo, 157-8535, Japan.

Natsuko Okita (N)

Department of Gastrointestinal Medical Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

Eishi Baba (E)

Department of Oncology and Social Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

Manabu Muto (M)

Department of Therapeutic Oncology, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shogoin, Sakyoku, Kyoto, 606-8507, Japan.

Iwaho Kikuchi (I)

Department of Obstetrics and Gynecology, Medical Park Yokohama, 1-1-8, Sakuragi-cho, Yokohama, Kanagawa, 231-0062, Japan.

Ken-Ichirou Morishige (KI)

Department of Obstetrics and Gynecology, Gifu University Graduate School of Medicine, 1-1, Yanagido, Gifu City, Gifu, 501-1194, Japan.

Koichiro Tsugawa (K)

Department of Breast and Endocrine Surgery, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae, Kawasaki, Kanagawa, 216-8511, Japan.

Hiroyuki Nishiyama (H)

Department of Urology, Faculty of Medicine, University of Tsukuba, Tennoudai, Tsukuba, Ibaraki, 305-8575, Japan.

Hajime Hosoi (H)

Department of Nursing, Doshisha Women's College of Liberal Arts, Kodo, Kyotanabe City, Kyoto, 610-0395, Japan.

Mitsune Tanimoto (M)

Chugoku Central Hospital, 148-13, Kamiiwanari, Miyuki-cho, Fukuyama-city, Hiroshima, 720-0001, Japan.

Akira Kawai (A)

Department of Musculoskeletal Oncology and Rehabilitation Medicine, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

Kazuhiko Sugiyama (K)

Department of Clinical Oncology and Neuro-Oncology Program, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.

Narikazu Boku (N)

Department of Medical Oncology and General Medicine, Institute of Medical Science, IMSUT Hospital, University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan.

Masato Yonemura (M)

Department of Pharmacy, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa-shi, Chiba, 277-0882, Japan.

Naoko Hayashi (N)

Graduate School of Nursing Science, St Luke's International University, 10-1 Akashi-cho, Chuo-ku, Tokyo, 104-0044, Japan.

Daisuke Aoki (D)

Department of Obstetrics and Gynecology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan.

Yutaka Osuga (Y)

Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo, Tokyo, 113-8655, Japan. yutakaos-tky@umin.ac.jp.

Nao Suzuki (N)

Department of Obstetrics and Gynecology, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae, Kawasaki, Kanagawa, 216-8511, Japan.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female
Humans United States Aged Cross-Sectional Studies Medicare Part C
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH