Acute systemic inhibition of inflammation augments endothelium-dependent dilation in women with a history of preeclamptic pregnancy.
Endothelial dysfunction
Inflammation
Microvascular
Preeclampsia
Journal
Pregnancy hypertension
ISSN: 2210-7797
Titre abrégé: Pregnancy Hypertens
Pays: Netherlands
ID NLM: 101552483
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
received:
08
09
2021
revised:
20
12
2021
accepted:
21
12
2021
pubmed:
2
1
2022
medline:
26
2
2022
entrez:
1
1
2022
Statut:
ppublish
Résumé
Women who have had preeclampsia demonstrate microvascular endothelial-dysfunction, mediated in part by reduced nitric oxide (NO)-dependent dilation. Preeclamptic pregnancies are associated with elevated inflammation, and inhibition of inflammation attenuates endothelial damage in animal models of preeclampsia. However, it is unclear if inhibition of vascular inflammation improves endothelial function in women after a preeclamptic pregnancy. Using the cutaneous microcirculation as a model, we hypothesized that acute systemic inhibition of vascular inflammation (oral salsalate; 1500 mg/twice daily, 4 days) would improve endothelium- and NO-dependent vasodilation in women with a history of preeclampsia (PE) but not in women with a history of uncomplicated pregnancy (HC). Twelve HC (30 ± 1yrs, 10 ± 2 months postpartum) and 10 PE (30 ± 2yrs, 8 ± 2 months postpartum) participated in a double-blind placebo-controlled study. Following each treatment, 2 intradermal microdialysis fibers were placed in the skin of the ventral forearm for graded infusion of acetylcholine (Ach, 10
Identifiants
pubmed: 34973597
pii: S2210-7789(21)00560-2
doi: 10.1016/j.preghy.2021.12.010
pmc: PMC8858855
mid: NIHMS1767902
pii:
doi:
Substances chimiques
Anti-Inflammatory Agents, Non-Steroidal
0
Salicylates
0
salicylsalicylic acid
V9MO595C9I
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
81-86Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR002537
Pays : United States
Organisme : NHLBI NIH HHS
ID : K99 HL138133
Pays : United States
Organisme : NHLBI NIH HHS
ID : R00 HL138133
Pays : United States
Organisme : NHLBI NIH HHS
ID : F32 HL129677
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL093238
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG049676
Pays : United States
Informations de copyright
Copyright © 2021 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.
Références
J Immunol Res. 2021 Jun 5;2021:9947884
pubmed: 34195300
J Clin Hypertens (Greenwich). 2021 May;23(5):1060-1067
pubmed: 33400389
Hipertens Riesgo Vasc. 2017 Apr - Jun;34(2):85-92
pubmed: 27394656
Am J Reprod Immunol. 2010 Jun;63(6):534-43
pubmed: 20331588
Clin Physiol. 1986 Aug;6(4):337-46
pubmed: 3527533
J Immunol. 2009 Dec 1;183(11):7023-30
pubmed: 19915051
Am J Physiol Heart Circ Physiol. 2004 Apr;286(4):H1389-93
pubmed: 15020302
Clin Sci (Lond). 2014 Dec;127(11):645-54
pubmed: 24947434
Cytokine. 2016 May;81:77-81
pubmed: 26954342
J Am Coll Cardiol. 2014 May 13;63(18):1815-22
pubmed: 24613324
Circulation. 2010 Aug 3;122(5):478-87
pubmed: 20644016
J Pregnancy. 2019 Mar 3;2019:9795765
pubmed: 30941219
Hypertension. 2017 Aug;70(2):382-389
pubmed: 28652473
JAMA. 2014 Feb 5;311(5):507-20
pubmed: 24352797
Hypertension. 2016 Nov;68(5):1298-1307
pubmed: 27733586
Am J Physiol Regul Integr Comp Physiol. 2018 Dec 1;315(6):R1062-R1071
pubmed: 30133302
JAMA. 2001 Mar 28;285(12):1607-12
pubmed: 11268269
Placenta. 2016 Jul;43:1-8
pubmed: 27324092
Vasc Health Risk Manag. 2011;7:467-74
pubmed: 21822394
N Engl J Med. 2017 Aug 17;377(7):613-622
pubmed: 28657417
Minerva Ginecol. 2010 Apr;62(2):105-20
pubmed: 20502423
Hypertension. 2011 Nov;58(5):935-42
pubmed: 21931069
Hypertension. 2008 Dec;52(6):1161-7
pubmed: 18981324
Acta Obstet Gynecol Scand. 1995 Nov;74(10):772-6
pubmed: 8533558
BMC Immunol. 2010 Dec 02;11:59
pubmed: 21126355
Ultrasound Obstet Gynecol. 2017 Jan;49(1):143-149
pubmed: 27804179
Atherosclerosis. 2013 Jul;229(1):234-9
pubmed: 23664201
Clin Sci (Lond). 2017 Nov 23;131(23):2777-2789
pubmed: 29042489
Hypertens Pregnancy. 2020 Nov;39(4):399-404
pubmed: 32646252
Hypertension. 2011 Jan;57(1):63-9
pubmed: 21115878
Am J Obstet Gynecol. 2014 Nov;211(5):516.e1-516.e11
pubmed: 24769012
Obstet Gynecol. 2020 Jun;135(6):e237-e260
pubmed: 32443079
J Cardiol. 2019 Jan;73(1):22-27
pubmed: 29907363
Eur J Prev Cardiol. 2012 Oct;19(5):1138-44
pubmed: 21859777
J Hypertens. 2015 Dec;33(12):2477-82
pubmed: 26378681
Acta Obstet Gynecol Scand. 2014 Dec;93(12):1309-16
pubmed: 25200856
Hypertension. 2016 Dec;68(6):1447-1458
pubmed: 27754864
Hypertension. 2010 Jul;56(1):166-71
pubmed: 20516394
Am J Physiol Heart Circ Physiol. 2008 Jan;294(1):H466-73
pubmed: 17993594
Hypertension. 2021 Sep;78(4):927-935
pubmed: 34397272
Hypertension. 2011 Jul;58(1):57-62
pubmed: 21606389
Hypertension. 2004 Nov;44(5):708-14
pubmed: 15452036
Pregnancy Hypertens. 2020 Jul;21:218-223
pubmed: 32683282
Am J Cardiol. 2004 Mar 15;93(6):805-8
pubmed: 15019902
Circulation. 2009 Mar 10;119(9):1284-92
pubmed: 19237660
BJOG. 2005 Mar;112(3):286-92
pubmed: 15713141
J Investig Med. 2015 Apr;63(4):641-5
pubmed: 25738648
J Hypertens. 2007 Nov;25(11):2301-7
pubmed: 17921826
BMJ. 2007 Nov 10;335(7627):974
pubmed: 17975258
Am J Physiol Regul Integr Comp Physiol. 2020 Jan 1;318(1):R148-R155
pubmed: 31577152