Biochemical characterization and insecticidal activity of isolated peptides from the venom of the scorpion Centruroides tecomanus.

Amino Acid Sequence Animals Insecticides Peptides Scorpion Venoms Scorpions
Chromatography Homology modeling Insecticidal toxin Mass spectrometry Peptides sequencing Scorpion venom

Journal

Toxicon : official journal of the International Society on Toxinology
ISSN: 1879-3150
Titre abrégé: Toxicon
Pays: England
ID NLM: 1307333

Informations de publication

Date de publication:
30 Jan 2022
Historique:
received: 12 10 2021
revised: 16 12 2021
accepted: 20 12 2021
pubmed: 3 1 2022
medline: 15 1 2022
entrez: 2 1 2022
Statut: ppublish

Résumé

The venom of scorpions is a mixture of components that constitute a source of bioactive molecules. The venom of the scorpion Centruroides tecomanus contains peptides toxic to insects, however, to date no toxin responsible for this activity has yet been isolated and fully characterized. This communication describes two new peptides Ct-IT1 and Ct-IT2 purified from this scorpion. Both peptides contain 63 amino acids with molecular weight 6857.85 for Ct-IT1 and 6987.77 Da for Ct-IT2. The soluble venom was separated using chromatographic techniques of molecular size exclusion, cationic exchange, and reverse phase chromatography, allowing the identification of at least 99 components of which in 53 the insecticidal activity was evaluated. The LD

Identifiants

DOI: 10.1016/j.toxicon.2021.12.015 PMID: 34973996
pubmed: 34973996
pii: S0041-0101(21)00456-6
doi: 10.1016/j.toxicon.2021.12.015
pii:
doi:

Substances chimiques

Insecticides 0
Peptides 0
Scorpion Venoms 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

90-102

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Auteurs

M J Bermúdez-Guzmán (MJ)

Facultad de Ciencias Químicas, Universidad de Colima, Km. 9 Carretera Colima-Coquimatlán, C.P. 28400, Coquimatlán, Colima, México; Instituto Nacional de Investigaciones Forestales, Agrícolas y Pecuarias (INIFAP), Km. 35 Carretera Colima-Manzanillo, C.P. 28100, Tecomán, Colima, México.

J M Jiménez-Vargas (JM)

CONACYT-Facultad de Ciencias Químicas, Universidad de Colima, Km. 9 Carretera-Coquimatlán, C.P. 28400, Coquimatlán, Colima, México.

L D Possani (LD)

Instituto de Biotecnología, Universidad Nacional Autónoma de México, Av. Universidad, 2001, Colonia Chamilpa, C.P. 510-3, Cuernavaca, Morelos, México.

F Zamudio (F)

Instituto de Biotecnología, Universidad Nacional Autónoma de México, Av. Universidad, 2001, Colonia Chamilpa, C.P. 510-3, Cuernavaca, Morelos, México.

G Orozco-Gutiérrez (G)

Instituto Nacional de Investigaciones Forestales, Agrícolas y Pecuarias (INIFAP), Km. 35 Carretera Colima-Manzanillo, C.P. 28100, Tecomán, Colima, México.

E Oceguera-Contreras (E)

Centro Universitario de los Valles, Universidad de Guadalajara, Km. 45.5 Carretera Guadalajara-Ameca, Ameca, Jalisco, México.

J N Enríquez-Vara (JN)

CONACYT-Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco A.C., Camino Arenero 1227, Col. El Bajío C.P. 45019, Zapopan, Jalisco, México.

O F Vazquez-Vuelvas (OF)

Facultad de Ciencias Químicas, Universidad de Colima, Km. 9 Carretera Colima-Coquimatlán, C.P. 28400, Coquimatlán, Colima, México.

P E García-Villalvazo (PE)

Facultad de Ciencias Químicas, Universidad de Colima, Km. 9 Carretera Colima-Coquimatlán, C.P. 28400, Coquimatlán, Colima, México.

L L Valdez-Velázquez (LL)

Facultad de Ciencias Químicas, Universidad de Colima, Km. 9 Carretera Colima-Coquimatlán, C.P. 28400, Coquimatlán, Colima, México. Electronic address: lauravaldez@ucol.mx.

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Classifications MeSH

questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Données de séquences moléculaires › Séquence d'acides aminés › Biochemical characterization and insecticidal...
questionsmedicales.fr › Eucaryotes › Animaux › Biochemical characterization and insecticidal...
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Pesticides › Insecticides › Biochemical characterization and insecticidal...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Biochemical characterization and insecticidal...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Venins › Venins d'arthropode › Venins de scorpion › Biochemical characterization and insecticidal...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Arthropodes › Arachnida › Scorpions › Biochemical characterization and insecticidal...