Sarcopenia in Hepatocellular Carcinoma: Pathogenesis and Management.
Branched-chain amino acids
Hepatocellular carcinoma
Muscle mass
Nutrition
Sarcopenia
Journal
Chemotherapy
ISSN: 1421-9794
Titre abrégé: Chemotherapy
Pays: Switzerland
ID NLM: 0144731
Informations de publication
Date de publication:
2022
2022
Historique:
received:
22
11
2021
accepted:
22
12
2021
pubmed:
3
1
2022
medline:
24
8
2022
entrez:
2
1
2022
Statut:
ppublish
Résumé
Sarcopenia is almost constantly observed in patients with cirrhosis and hepatocellular carcinoma (HCC). Chronic liver disease represents a unique pathophysiological scenario in which sarcopenia develops and all factors involved in the pathogenesis should be taken into account for an appropriate management of the disease. No properly designed intervention studies on this topic are available and, thus, no effective strategies have been developed for clinical practice. Apart from any targeted intervention, treatment, and optimization of liver disease is crucial. In patients with cirrhosis and HCC, nutritional support to maintain and restore nutrition status, a targeted use of branched-chain amino acids and a guided physical exercise, should all be an integral part of the multidimensional assessment and tailored interventions.
Sections du résumé
BACKGROUND
BACKGROUND
Sarcopenia is almost constantly observed in patients with cirrhosis and hepatocellular carcinoma (HCC).
SUMMARY
CONCLUSIONS
Chronic liver disease represents a unique pathophysiological scenario in which sarcopenia develops and all factors involved in the pathogenesis should be taken into account for an appropriate management of the disease. No properly designed intervention studies on this topic are available and, thus, no effective strategies have been developed for clinical practice. Apart from any targeted intervention, treatment, and optimization of liver disease is crucial.
KEY MESSAGES
CONCLUSIONS
In patients with cirrhosis and HCC, nutritional support to maintain and restore nutrition status, a targeted use of branched-chain amino acids and a guided physical exercise, should all be an integral part of the multidimensional assessment and tailored interventions.
Identifiants
pubmed: 34974449
pii: 000521741
doi: 10.1159/000521741
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
152-163Informations de copyright
© 2021 S. Karger AG, Basel.