Determination of a Cut-off Point for Exhaled Nitric Oxide in the Diagnosis of Asthma in an Iranian Population.
Asthma
Cut-off Point
Exhaled Nitric Oxide
Journal
Tanaffos
ISSN: 1735-0344
Titre abrégé: Tanaffos
Pays: Iran
ID NLM: 101308232
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
15
01
2020
accepted:
19
09
2020
entrez:
3
1
2022
pubmed:
4
1
2022
medline:
4
1
2022
Statut:
ppublish
Résumé
Asthma is a major source of global social and economic burden; thus, its early detection is important. Measurement of fractional exhaled nitric oxide (FENO) has been used recently considered a good indicator of asthma and also a sensitive and non-invasive method for monitoring airway inflammation. This study was conducted to determine the cut-off point of FENO for the diagnosis of asthma in the studied population. The subjects of this cross-sectional diagnostic study were assessed by the FENO test, spirometry, and methacholine challenge test. The best cut-off point of the FENO for the diagnosis of asthma was determined. The data were analyzed by SPSS 20 using student t-test, and Chi-square test and the ROC curves were also drawn. The mean FENO in asthmatic and non-asthmatic subjects was 43.5±33.41 and 17.5±21.48 ppb, respectively (P <0.001). The best cut-off point of the FENO based on the overall sensitivity and specificity was 39.5 ppb. According to the results of this study, symptomatic patients with FENO higher than 39.5 ppb could be considered as asthmatic.
Sections du résumé
BACKGROUND
BACKGROUND
Asthma is a major source of global social and economic burden; thus, its early detection is important. Measurement of fractional exhaled nitric oxide (FENO) has been used recently considered a good indicator of asthma and also a sensitive and non-invasive method for monitoring airway inflammation. This study was conducted to determine the cut-off point of FENO for the diagnosis of asthma in the studied population.
MATERIALS AND METHODS
METHODS
The subjects of this cross-sectional diagnostic study were assessed by the FENO test, spirometry, and methacholine challenge test. The best cut-off point of the FENO for the diagnosis of asthma was determined. The data were analyzed by SPSS 20 using student t-test, and Chi-square test and the ROC curves were also drawn.
RESULTS
RESULTS
The mean FENO in asthmatic and non-asthmatic subjects was 43.5±33.41 and 17.5±21.48 ppb, respectively (P <0.001). The best cut-off point of the FENO based on the overall sensitivity and specificity was 39.5 ppb.
CONCLUSION
CONCLUSIONS
According to the results of this study, symptomatic patients with FENO higher than 39.5 ppb could be considered as asthmatic.
Types de publication
Journal Article
Langues
eng
Pagination
150-155Informations de copyright
Copyright© 2021 National Research Institute of Tuberculosis and Lung Disease.
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