Unraveling unique and common cell type-specific mechanisms in glioblastoma multiforme.
CAMs, Cell adhesion molecules
CNS, Cental nervous system
DEG, Differentially expressed genes
EMT, Epithelial-mesenchymal transistion
GBM, Glioblastoma multiforme
GSC, Glioblastoma Stem Cell
Glial cell types
Glioblastoma multiforme
INstruct, a database of structurally resolved protein interactome
MO, Myelinating oligodendrocyte
NCBI, National Centre for Biotechnology Information
NFO, Newly formed oligodendrocyte
NPC, Neural progenitor cell
OPC, Oligodendrocyte precursor cell
PDI, Protein domain interactions
PDIN, Protein domain interaction network
PPI, Protein-protein interactions
Primary solid tumour
Protein domains
Protein interaction networks
RSEM, RNA-seq by Expectation-Maximization
Recurrent solid tumour transcription factors
SIGNOR, Signaling Network Open Resource
TCGA, The Cancer Genome Atlas
TF, Transcription factor
TP, Primary solid tumour
TR, Recurrent solid tumour
WHO, World health organization
iDEP, Integrated Differential Expression and Pathway analysis
Journal
Computational and structural biotechnology journal
ISSN: 2001-0370
Titre abrégé: Comput Struct Biotechnol J
Pays: Netherlands
ID NLM: 101585369
Informations de publication
Date de publication:
2022
2022
Historique:
received:
12
08
2021
revised:
22
11
2021
accepted:
06
12
2021
entrez:
3
1
2022
pubmed:
4
1
2022
medline:
4
1
2022
Statut:
epublish
Résumé
Glioblastoma multiforme persists to be an enigmatic distress in neuro-oncology. Its untethering capacity to thrive in a confined microenvironment, metastasize intracranially, and remain resistant to the systemic treatments, renders this tumour incurable. The glial cell type specificity in GBM remains exploratory. In our study, we aimed to address this problem by studying the GBM at the cell type level in the brain. The cellular makeup of this tumour is composed of genetically altered glial cells which include astrocyte, microglia, oligodendrocyte precursor cell, newly formed oligodendrocyte and myelinating oligodendrocyte. We extracted cell type-specific solid tumour as well as recurrent solid tumour glioma genes, and studied their functional networks and contribution towards gliomagenesis. We identified the principal transcription factors that are found to be regulating vital tumorigenic processes. We also assessed the protein-protein interaction networks at their domain level to get a more microscopic view of the structural and functional operations that transpire in these cells. This yielded the eminent protein regulators exhibiting their regulation in signaling pathways. Overall, our study unveiled regulatory mechanisms in glioma cell types that can be targeted for a more efficient glioma therapy.
Identifiants
pubmed: 34976314
doi: 10.1016/j.csbj.2021.12.010
pii: S2001-0370(21)00518-3
pmc: PMC8688884
doi:
Types de publication
Journal Article
Langues
eng
Pagination
90-106Informations de copyright
© 2021 The Author(s).
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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