Metabolic Impairment in Coronary Artery Disease: Elevated Serum Acylcarnitines Under the Spotlights.
acylcarnitine
branched-chain amino acids
carnitine
coronary artery disease
fatty acid oxidation (FAO)
metabolomics
mitochondria
Journal
Frontiers in cardiovascular medicine
ISSN: 2297-055X
Titre abrégé: Front Cardiovasc Med
Pays: Switzerland
ID NLM: 101653388
Informations de publication
Date de publication:
2021
2021
Historique:
received:
10
10
2021
accepted:
09
11
2021
entrez:
3
1
2022
pubmed:
4
1
2022
medline:
4
1
2022
Statut:
epublish
Résumé
Coronary artery disease (CAD) remains the leading cause of death worldwide. Expanding patients' metabolic phenotyping beyond clinical chemistry investigations could lead to earlier recognition of disease onset and better prevention strategies. Additionally, metabolic phenotyping, at the molecular species level, contributes to unravel the roles of metabolites in disease development. In this cross-sectional study, we investigated clinically healthy individuals (
Identifiants
pubmed: 34977199
doi: 10.3389/fcvm.2021.792350
pmc: PMC8716394
doi:
Types de publication
Journal Article
Langues
eng
Pagination
792350Informations de copyright
Copyright © 2021 Gander, Carrard, Gallart-Ayala, Borreggine, Teav, Infanger, Colledge, Streese, Wagner, Klenk, Nève, Knaier, Hanssen, Schmidt-Trucksäss and Ivanisevic.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Diabetes. 2013 Jan;62(1):1-8
pubmed: 23258903
Mol Cell Biochem. 1992 Oct 21;116(1-2):103-9
pubmed: 1282666
Heart Fail Clin. 2014 Apr;10(2):353-65
pubmed: 24656111
J Am Heart Assoc. 2016 Jul 29;5(8):
pubmed: 27473038
Cell Metab. 2012 May 2;15(5):606-14
pubmed: 22560213
Biochim Biophys Acta Mol Basis Dis. 2020 May 1;1866(5):165720
pubmed: 32057943
PLoS One. 2013 Dec 16;8(12):e82459
pubmed: 24358186
Diabetes Care. 2016 Sep;39(9):1563-70
pubmed: 27388475
Mol Cell Biochem. 2014 Oct;395(1-2):1-10
pubmed: 24878991
Cell Metab. 2017 Feb 7;25(2):374-385
pubmed: 28178567
Clin Chem. 2016 Apr;62(4):582-92
pubmed: 26888892
Pediatr Res. 1999 Oct;46(4):440-4
pubmed: 10509365
J Lipid Res. 2012 Jul;53(7):1296-303
pubmed: 22534643
Diabetologia. 2014 Jan;57(1):167-76
pubmed: 24100782
J Am Heart Assoc. 2017 Sep 28;6(10):
pubmed: 28963102
Obesity (Silver Spring). 2010 Sep;18(9):1695-700
pubmed: 20111019
Diabetes Care. 2009 Sep;32(9):1678-83
pubmed: 19502541
J Am Coll Cardiol. 2011 Apr 12;57(15):1604-10
pubmed: 21474041
Nutr Metab Cardiovasc Dis. 2018 Apr;28(4):393-401
pubmed: 29422298
J Nutr. 2009 Jun;139(6):1073-81
pubmed: 19369366
PLoS One. 2017 Nov 9;12(11):e0187729
pubmed: 29121091
Naunyn Schmiedebergs Arch Pharmacol. 2013 Jun;386(6):541-50
pubmed: 23525500
J Toxicol Sci. 2014 Apr;39(2):331-7
pubmed: 24646715
J Card Fail. 1998 Jun;4(2):121-6
pubmed: 9730105
Front Cardiovasc Med. 2021 Jan 20;7:622236
pubmed: 33553267
Am J Physiol. 1980 May;238(5):E409-15
pubmed: 7377339
Nat Rev Mol Cell Biol. 2016 Jul;17(7):451-9
pubmed: 26979502
Diabetes. 2000 May;49(5):677-83
pubmed: 10905472
Basic Res Cardiol. 1984 Sep-Oct;79(5):551-61
pubmed: 6508713
Vasc Health Risk Manag. 2014 Nov 07;10:641-7
pubmed: 25404859
Am J Physiol Heart Circ Physiol. 2016 Nov 1;311(5):H1160-H1169
pubmed: 27542406
Metabolites. 2019 Jun 18;9(6):
pubmed: 31216675
Am Heart J. 2012 May;163(5):844-850.e1
pubmed: 22607863
Eur Heart J. 2020 Jan 7;41(2):255-323
pubmed: 31497854
Annu Rev Biochem. 2006;75:295-332
pubmed: 16756494
Diabetes. 2004 Jan;53(1):221-7
pubmed: 14693719
Int J Cardiol. 2013 Sep 1;167(5):1892-9
pubmed: 22622056
Curr Probl Cardiol. 1994 Feb;19(2):59-113
pubmed: 8174388
Circ Cardiovasc Genet. 2010 Apr;3(2):207-14
pubmed: 20173117
J Med Biochem. 2018 Dec 01;37(4):426-433
pubmed: 30584401
Nat Rev Endocrinol. 2015 Oct;11(10):617-25
pubmed: 26303601
Nutr Res. 2012 Jul;32(7):479-85
pubmed: 22901555
Obesity (Silver Spring). 2017 Feb;25(2):323-331
pubmed: 28000430
Am J Physiol Endocrinol Metab. 2015 Oct 15;309(8):E736-46
pubmed: 26306599
Eur Heart J Cardiovasc Pharmacother. 2018 Jan 1;4(1):25-35
pubmed: 28444162
Drugs Aging. 1998 Mar;12(3):243-8; discussion 249-50
pubmed: 9534023
PLoS Med. 2008 Mar 11;5(3):e51
pubmed: 18336063
Chronobiol Int. 2012 Aug;29(7):868-81
pubmed: 22823870
Am J Kidney Dis. 2003 Apr;41(4 Suppl 4):S4-12
pubmed: 12751049
Nutr Metab Cardiovasc Dis. 2015 Oct;25(10):937-42
pubmed: 26231617
J Clin Invest. 2009 Jun;119(6):1678-87
pubmed: 19411760
J Huazhong Univ Sci Technolog Med Sci. 2014 Apr;34(2):276-283
pubmed: 24710945
Ann Clin Biochem. 2008 Nov;45(Pt 6):585-92
pubmed: 18782814
Physiol Rev. 2019 Oct 1;99(4):1819-1875
pubmed: 31434538
Nutr Metab (Lond). 2018 Jan 29;15:10
pubmed: 29422939
Free Radic Biol Med. 2021 Mar;165:24-37
pubmed: 33484825
Sci Rep. 2017 Dec 13;7(1):17528
pubmed: 29235526
Annu Rev Nutr. 1984;4:409-54
pubmed: 6380539
Mol Nutr Food Res. 2015 Aug;59(8):1573-83
pubmed: 25913736
Eur J Nutr. 2017 Mar;56(2):671-681
pubmed: 26658764
Expert Rev Gastroenterol Hepatol. 2011 Apr;5(2):233-44
pubmed: 21476918
Lipids. 1996 Aug;31(8):867-70
pubmed: 8869889
Int J Epidemiol. 2016 Dec 1;45(6):1887-1894
pubmed: 28089956
J Gastroenterol Hepatol. 2000 Jul;15(7):706-17
pubmed: 10937674
Atherosclerosis. 2014 Feb;232(2):260-4
pubmed: 24468136
Cell Metab. 2008 Jan;7(1):45-56
pubmed: 18177724
IUBMB Life. 2017 Aug;69(8):578-594
pubmed: 28653367
Circ Cardiovasc Genet. 2016 Dec;9(6):487-494
pubmed: 27784734
Glob Heart. 2016 Dec;11(4):393-397
pubmed: 27938824
Biochim Biophys Acta. 2014 Jul;1841(7):987-94
pubmed: 24747043
Anal Chem. 2019 Sep 17;91(18):11757-11769
pubmed: 31407894
J Mol Med (Berl). 2010 Oct;88(10):993-1001
pubmed: 20725711
Arch Dis Child. 1989 Oct;64(10 Spec No):1410-5
pubmed: 2686556
Cell Metab. 2009 Apr;9(4):311-26
pubmed: 19356713
J Gerontol A Biol Sci Med Sci. 2017 Oct 1;72(10):1352-1359
pubmed: 28052980
Diabetes Care. 2013 Mar;36(3):648-55
pubmed: 23129134
J Mol Cell Cardiol. 2001 Jun;33(6):1065-89
pubmed: 11444914
Diabetologia. 2010 Apr;53(4):757-67
pubmed: 20076942
Cell Metab. 2017 Jan 10;25(1):43-56
pubmed: 28094011
World J Biol Chem. 2015 Nov 26;6(4):301-9
pubmed: 26629313
J Am Coll Cardiol. 2016 Jan 26;67(3):291-9
pubmed: 26796394
BMC Cardiovasc Disord. 2019 Jul 30;19(1):180
pubmed: 31362698
Am J Cardiol. 1983 Feb;51(3):606
pubmed: 6823874
J Cell Mol Med. 2009 May;13(5):811-25
pubmed: 19382894
Curr Opin Cardiol. 2010 Jul;25(4):329-34
pubmed: 20535068
Eur Heart J. 2004 Apr;25(8):634-41
pubmed: 15084367
Basic Res Cardiol. 1987;82 Suppl 1:63-73
pubmed: 3311010
Clin Pharmacokinet. 2012 Sep 1;51(9):553-72
pubmed: 22804748
Biochem J. 2016 May 1;473(9):1191-202
pubmed: 26936967
Nature. 2020 Dec;588(7836):135-140
pubmed: 33177712
J Lipid Res. 2010 Oct;51(10):2863-95
pubmed: 20558530
J Biol Chem. 1978 Jun 25;253(12):4305-9
pubmed: 659417
Nat Med. 2011 Apr;17(4):448-53
pubmed: 21423183
Atherosclerosis. 2014 Jan;232(1):191-6
pubmed: 24401236
Sci Rep. 2018 Oct 25;8(1):15809
pubmed: 30361499
PLoS One. 2012;7(6):e40009
pubmed: 22761945
Eur Heart J. 2021 Sep 21;42(36):3599-3726
pubmed: 34447992
J Am Coll Cardiol. 2009 Dec 15;54(25):2435-46
pubmed: 20082935
PLoS One. 2017 Aug 16;12(8):e0183228
pubmed: 28813537
BMC Med Res Methodol. 2008 Oct 30;8:70
pubmed: 18973665
FASEB J. 1999 Sep;13(12):1501-10
pubmed: 10463940
J Am Heart Assoc. 2017 Feb 3;6(2):
pubmed: 28159823
Clin Chim Acta. 2020 Aug;507:250-256
pubmed: 32376321
Nat Commun. 2020 Sep 8;11(1):4487
pubmed: 32900998
Metabolites. 2019 Jul 02;9(7):
pubmed: 31269707
Aging (Albany NY). 2020 Jun 16;12(13):13555-13570
pubmed: 32554854
JACC Cardiovasc Imaging. 2020 Sep;13(9):1961-1972
pubmed: 32563656
Biochem Biophys Res Commun. 2009 Oct 30;388(4):643-7
pubmed: 19665003
Cell Chem Biol. 2019 Jan 17;26(1):71-84.e4
pubmed: 30415965
Annu Rev Physiol. 1974;36:413-59
pubmed: 19400669
Eur Heart J. 2020 Jan 1;41(1):111-188
pubmed: 31504418
Vascul Pharmacol. 2016 Mar;78:17-23
pubmed: 26133667
J Hypertens. 2018 Oct;36(10):1953-2041
pubmed: 30234752
Circulation. 1999 Nov 30;100(22):2248-53
pubmed: 10577999
Metabolism. 1978 May;27(5):555-61
pubmed: 642827
Curr Opin Chem Biol. 2017 Feb;36:15-23
pubmed: 28064089
Sci Rep. 2021 Mar 18;11(1):6197
pubmed: 33737653
Metabolites. 2021 Jan 14;11(1):
pubmed: 33466750
Am J Clin Nutr. 1971 Mar;24(3):329-41
pubmed: 4396448
Ann N Y Acad Sci. 2004 Nov;1033:79-91
pubmed: 15591005
PLoS Genet. 2011 Aug;7(8):e1002215
pubmed: 21852955
J Am Coll Cardiol. 2020 Dec 22;76(25):2982-3021
pubmed: 33309175