Bioengineering
Cell biology
Cellular physiology
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
21 Jan 2022
21 Jan 2022
Historique:
entrez:
3
1
2022
pubmed:
4
1
2022
medline:
4
1
2022
Statut:
epublish
Résumé
Non-alcoholic fatty liver disease (NAFLD) represents a global healthcare challenge, affecting 1 in 4 adults, and death rates are predicted to rise inexorably. The progressive form of NAFLD, non-alcoholic steatohepatitis (NASH), can lead to fibrosis, cirrhosis, and hepatocellular carcinoma. However, no medical treatments are licensed for NAFLD-NASH. Identifying efficacious therapies has been hindered by the complexity of disease pathogenesis, a paucity of predictive preclinical models and inadequate validation of pharmacological targets in humans. The development of clinically relevant
Identifiants
pubmed: 34977507
doi: 10.1016/j.isci.2021.103549
pii: S2589-0042(21)01519-4
pmc: PMC8689151
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
103549Informations de copyright
© 2021 The Author(s).
Déclaration de conflit d'intérêts
JA Fallowfield has served as a consultant or advisory board member for Redx Pharma, Novartis, Ferring Pharmaceuticals, Macrophage Pharma, Galecto Biotech, Caldan Therapeutics, Cypralis Ltd, Rallybio, Tectonic Therapeutic, River 2 Renal Corp.,Gilde Healthcare, Guidepoint, Techspert.io and has received research grant funding from Novartis and Intercept Pharmaceuticals. M Jimenez-Ramos MRC iCASE PhD studentship is partially funded by Galecto Biotech.
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