Cognition in older adults with bipolar disorder: An ISBD task force systematic review and meta-analysis based on a comprehensive neuropsychological assessment.
bipolar disorder
cognition
elderly
meta-analysis
neuropsychology
older adults
systematic review
Journal
Bipolar disorders
ISSN: 1399-5618
Titre abrégé: Bipolar Disord
Pays: Denmark
ID NLM: 100883596
Informations de publication
Date de publication:
03 2022
03 2022
Historique:
pubmed:
4
1
2022
medline:
6
4
2022
entrez:
3
1
2022
Statut:
ppublish
Résumé
We aim to characterize the cognitive performance in euthymic older adults with bipolar disorder (OABD) through a comprehensive neuropsychological assessment to obtain a detailed neuropsychological profile. We conducted a systematic search in MEDLINE/Pubmed, Cochrane, and PsycInfo databases. Original studies assessing cognitive function in OABD (age ≥50 years ) containing, at a minimum, the domains of attention/processing speed, memory, and executive functions were included. A random-effects meta-analysis was conducted to summarize differences between patients and matched controls in each cognitive domain. We also conducted meta-regressions to estimate the impact of clinical and socio-demographic variables on these differences. Eight articles, providing data for 328 euthymic OABD patients and 302 healthy controls, were included in the meta-analysis. OABD showed worse performance in comparison with healthy controls, with large significant effect sizes (Hedge's g from -0.77 to -0.89; p < 0.001) in verbal learning and verbal and visual delayed memory. They also displayed statistically significant deficits, with moderate effect size, in processing speed, working memory, immediate memory, cognitive flexibility, verbal fluency, psychomotor function, executive functions, attention, inhibition, and recognition (Hedge's g from -0.52 to -0.76; p < 0.001), but not in language and visuoconstruction domains. None of the examined variables were associated with these deficits. Cognitive dysfunction is present in OABD, with important deficits in almost all cognitive domains, especially in the memory domain. Our results highlight the importance of including a routine complete neuropsychological assessment in OABD and also considering therapeutic strategies in OABD.
Types de publication
Journal Article
Meta-Analysis
Review
Systematic Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
115-136Subventions
Organisme : NIMH NIH HHS
ID : R01 MH113230
Pays : United States
Commentaires et corrections
Type : CommentIn
Type : ErratumIn
Informations de copyright
© 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Références
Sajatovic M. New-onset bipolar disorder in later life. Am J Geriatr Psychiatry. 2005;13(4):282-289. doi:10.1176/appi.ajgp.13.4.282
Rej S, Quayle W, Forester BP, et al. Measurement tools for assessment of older age bipolar disorder: a systematic review of the recent global literature. Bipolar Disord. 2018;20(4):359-369. doi:10.1111/bdi.12566
Nivoli AMA, Murru A, Pacchiarotti I, et al. Bipolar disorder in the elderly: a cohort study comparing older and younger patients. Acta Psychiatr Scand. 2014;130(5):364-373. doi:10.1111/acps.12272
Kessing LV. Diagnostic subtypes of bipolar disorder in older versus younger adults. Bipolar Disord. 2006;8(1):56-64. doi:10.1111/j.1399-5618.2006.00278.x
Sajatovic M, Eyler LT, Rej S, et al. The global aging & geriatric experiments in bipolar disorder database (GAGE-BD) project: understanding older-age bipolar disorder by combining multiple datasets. Bipolar Disord. 2019;1-8. doi:10.1111/bdi.12795
Sajatovic M, Strejilevich SA, Gildengers AG, et al. A report on older-age bipolar disorder from the international society for bipolar disorders task force. Bipolar Disord. 2015;17(7):689-704. doi:10.1111/bdi.12331
Robinson LJ, Thompson JM, Gallagher P, et al. A meta-analysis of cognitive deficits in euthymic patients with bipolar disorder. J Affect Disord. 2006;93(1-3):105-115. doi:10.1016/j.jad.2006.02.016
Torres IJ, Boudreau VG, Yatham LN. Neuropsychological functioning in euthymic bipolar disorder: a meta-analysis. Acta Psychiatr Scand. 2007;116(SUPPL. 434):17-26. doi:10.1111/j.1600-0447.2007.01055.x
Bora E. Neurocognitive features in clinical subgroups of bipolar disorder: a meta-analysis. J Affect Disord. 2018;229:125-134. doi:10.1016/j.jad.2017.12.057
Gildengers AG, Butters MA, Seligman K, et al. Cognitive functioning in late-life bipolar disorder. Am J Psychiatry. 2004;161(4):736-738. doi:10.1176/appi.ajp.161.4.736
Samamé C, Martino DJ, Strejilevich SA. A quantitative review of neurocognition in euthymic late-life bipolar disorder. Bipolar Disord. 2013;15(6):633-644. doi:10.1111/bdi.12077
Comes M, Rosa A, Reinares M, Torrent C, Vieta E. Functional impairment in older adults with bipolar disorder. J Nerv Ment Dis. 2017;205(6):443-447. doi:10.1097/NMD.0000000000000683
Pennarts HM, Schouws SNTM, Bongers IMB. Cognitive functioning in relation to self-care in elderly persons with a bipolar disorder. Clin Gerontol. 2014;37(5):419-428. doi:10.1080/07317115.2014.907589
Gildengers AG, Chisholm D, Butters MA, et al. Two-year course of cognitive function and instrumental activities of daily living in older adults with bipolar disorder: evidence for neuroprogression? Psychol Med. 2013;43(4):801-811. doi:10.1017/S0033291712001614
Orhan M, Korten N, Stek M, Comijs H, Schouws S, Dols A. The relationship between cognitive and social functioning in older patients with bipolar disorder. J Affect Disord. 2018;240:177-182. doi:10.1016/j.jad.2018.07.055
Kessing LV, Andersen PK. Evidence for clinical progression of unipolar and bipolar disorders. Acta Psychiatr Scand. 2017;135(1):51-64. doi:10.1111/acps.12667
Szmulewicz A, Valerio MP, Martino DJ. Longitudinal analysis of cognitive performances in recent-onset and late-life bipolar disorder: a systematic review and meta-analysis. Bipolar Disord. 2020;22(1):28-37. doi:10.1111/bdi.12841
Diniz BS, Teixeira AL, Cao F, et al. History of bipolar disorder and the risk of dementia: a systematic review and meta-analysis. Am J Geriatr Psychiatry. 2017;25(4):357-362. doi:10.1016/j.jagp.2016.11.014
Velosa J, Delgado A, Finger E, Berk M, Kapczinski F, de Azevedo CT. Risk of dementia in bipolar disorder and the interplay of lithium: a systematic review and meta-analyses. Acta Psychiatr Scand. 2020;141(6):510-521. doi:10.1111/acps.13153
da Silva J, Gonçalves-Pereira M, Xavier M, Mukaetova-Ladinska EB. Affective disorders and risk of developing dementia: systematic review. Br J Psychiatry. 2013;202(03):177-186. doi:10.1192/bjp.bp.111.101931
Chen M-H, Li C-T, Tsai C-F, et al. Risk of subsequent dementia among patients with bipolar disorder or major depression: a nationwide longitudinal study in Taiwan. J Am Med Dir Assoc. 2015;16(6):504-508. doi:10.1016/j.jamda.2015.01.084
Wu K-Y, Chang C-M, Liang H-Y, et al. Increased risk of developing dementia in patients with bipolar disorder: a nested matched case-control study. Bipolar Disord. 2013;15(7):787-794. doi:10.1111/bdi.12116
Kessing LV, Nilsson FM. Increased risk of developing dementia in patients with major affective disorders compared to patients with other medical illnesses. J Affect Disord. 2003;73(3):261-269. doi:10.1016/S0165-0327(02)00004-6
Strauss E, Sherman EM, Spreen O. A Compendium of Neuropsychological Tests: Administration, Norms, and Commentary - Esther Strauss, Elisabeth M. S. Sherman, Otfried Spreen - Google Books. Oxford University Press; 2006. doi:10.1212/WNL.41.11.1856-a
Lezak MD. Neuropsychological Assessment. Oxford University Press; 2012.
Miskowiak KW, Burdick KE, Martinez-Aran A, et al. Assessing and addressing cognitive impairment in bipolar disorder: the international society for bipolar disorders targeting cognition task force recommendations for clinicians. Bipolar Disord. 2018;20(3):184-194. doi:10.1111/bdi.12595
Moher D, Liberati A, Tetzlaff J, Altman DG; PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Medicine. 2009;6(7):e1000097. doi:10.1371/journal.pmed.1000097
Wechsler D. Manual for the Wechsler Adult Intelligence Scale-Revised. New York Psychological Corporation; 1981.
Randolph C, Tierney MC, Mohr E, Chase TN. The repeatable battery for the assessment of neuropsychological status (RBANS): preliminary clinical validity. J Clin Exp Neuropsychol. 1998;20(3):310-319. doi:10.1076/jcen.20.3.310.823
Vaccarino SR, Rajji TK, Gildengers AG, et al. Allostatic load but not medical burden predicts memory performance in late-life bipolar disorder. Int J Geriatr Psychiatry. 2018;33(3):546-552. doi:10.1002/gps.4829
Gildengers AG, Butters MA, Chisholm D, et al. Cognitive functioning and instrumental activities of daily living in late-life bipolar disorder. Am J Geriatr Psychiatry. 2007;15(2):174-179. doi:10.1097/JGP.0b013e31802dd367
Conners CK, Staff M. Conners’ Continuous Performance Test II: Computer Program for Windows Technical Guide and Software Manual. Mutli-Health Systems; 2000. . Accessed April 30, 2020
Wechsler WD. Memory Scale. 3rd ed. Psychological Corporation; 1997.
Hultsch DF, MacDonald SW, Hunter MA, Levy-Bencheton J, Strauss E. Intraindividual variability in cognitive performance in older adults: comparison of adults with mild dementia, adults with arthritis, and healthy adults. Neuropsychology. 2000;14(4):588-598. doi:10.1037//0894-4105.14.4.588
Salthouse TA, Babcock RL. Decomposing adult age differences in working memory. Dev Psychol. 1991;27(5):763-776. doi:10.1037/0012-1649.27.5.763
Reitan R, Wolfson D. The Halstead-Reitan Neuropsychological Test Battery. Neuropsychology Press; 1993.
Wechsler D. The Wechsler Adult Intelligence Scale - III (WAIS-III). Psychological Corporation; 1997.
Matthews CG, Klove K. Instruction Manual for the Adult Neuropsychology Test Battery. University of Wisconsin Medical School; 1964.
Schmand B, Lindeboom J, Schagen S, Heijt R, Koene T, Hamburger HL. Cognitive complaints in patients after whiplash injury: the impact of malingering. J Neurol Neurosurg Psychiatry. 1998;64(3):339-343. doi:10.1136/jnnp.64.3.339
Rouleau I, Salmon DP, Butters N, Kennedy C, McGuire K. Quantitative and qualitative analyses of clock drawings in Alzheimer’s and Huntington’s disease. Brain Cogn. 1992;18(1):70-87. doi:10.1016/0278-2626(92)90112-y
Shulman KI, Pushkar Gold D, Cohen CA, Zucchero CA. Clock-drawing and dementia in the community: a longitudinal study. Int J Geriatr Psychiatry. 1993;8(6):487-496. doi:10.1002/gps.930080606
Osterrieth P. Le test de copie d’une figure complexe; contribution à l’étude de la perception et de la mémoire [Test of copying a complex figure; contribution to the study of perception and memory]. Arch Psychol (Geneve). 1944;30:206-356. https://psycnet.apa.org/record/1946-02126-001 Accessed April 16, 2020
Rey A. Psychological examination of traumatic encephalopathy. Arch Psychol. 1941;28:286-340.
Goodglass H, Kaplan E. The Assessment of Aphasia and Related Disorders. Lea & Febiger; 1983.
Lindeboom J, Jonker C. Amsterdam Dementia Screenings Test ADS6. Swets and Zeilinger; 1989.
Wechsler D. Wechsler Adult Intelligence Scale-Revised. Psychological Corporation; 1955.
Delaloye C, Ludwig C, Borella E, Chicherio C, de Ribaupierre A. L’Empan de lecture comme épreuve mesurant la capacité de mémoire de travail : normes basées sur une population francophone de 775 adultes jeunes et âgés. Eur Rev Appl Psychol. 2008;58(2):89-103. doi:10.1016/j.erap.2006.12.004
Ivanoiu A, Adam S, Linden M, et al. Memory evaluation with a new cued recall test in patients with mild cognitive impairment and Alzheimer’s disease. J Neurol. 2005;252(1):47-55. doi:10.1007/s00415-005-0597-2
Morris JC, Heyman A, Mohs RC, et al. The consortium to establish a registry for Alzheimer’s disease (CERAD). Part I. Clinical and neuropsychological assessment of Alzheimer’s disease. Neurology. 1989;39(9):1159-1165. doi:10.1212/wnl.39.9.1159
Rey A. L’examen Clinique En Psychologie. Presses Universitaires de France; 1964.
Delis DC, Freeland J, Kramer JH, Kaplan E. Integrating clinical assessment with cognitive neuroscience: construct validation of the California verbal learning test. J Consult Clin Psychol. 1988;56(1):123-130. doi:10.1037/0022-006X.56.1.123
Signoret J, Whiteley A. A memory battery scale. Int Neuropsychol Soc. 1979;2:2-26.
Stroop JR. Studies of interference in serial verbal reactions. J Exp Psychol Gen. 1935;18:643-661.
Trenerry M, Crosson B, DeBoe J, Leber W. The Stroop Neuropsychological Test. Fla: Psychological Assessment Resources; 1989.
Golden C. The Stroop Color and Word Test: A Manual for Clinical and Experimental Uses. Stoelting; 1978.
Rogers RD, Monsell S. Costs of a predictible switch between simple cognitive tasks. J Exp Psychol Gen. 1995;124(2):207-231. doi:10.1037/0096-3445.124.2.207
de Ribaupierre A, Borella E, Bozon F, Delaloye C, Joly-Pottuz B, Jouffray C. Dimensionnalité de l’Inhibition Cognitive Au Travers Du Lifespan: Descriptif Des Épreuves Utilisées. Unpublished manuscript; 1999.
Benton A, Hamsher K, Sivan A. Multilingual Aphasia Examinationn. 3rd ed. AJA Associates; 1983.
Borkowski JG, Benton AL, Spreen O. Word fluency and brain damage. Neuropsychologia. 1967;5(2):135-140. doi:10.1016/0028-3932(67)90015-2
Cardebat D, Doyon B, Puel M, Goulet P, Joanette Y. Formal and semantic lexical evocation in normal subjects. Performance and dynamics of production as a function of sex, age and educational level. Acta Neurol Belg. 1990;90(4):207-217. http://www.ncbi.nlm.nih.gov/pubmed/2124031 Accessed April 16, 2020
Luteijn F, van der Ploeg F. Manual Groningen Intelligence Test. Swets and Zeitlinger; 1983.
Berg EA. A simple objective technique for measuring flexibility in thinking. J Gen Psychol. 1948;39(1):15-22. doi:10.1080/00221309.1948.9918159
Heaton RK. Wisconsin Card Sorting Test Manual. Psychological Asessment Resources; 1981.
Maj M, D’Elia L, Satz P, et al. Evaluation of two new neuropsychological tests designed to minimize cultural bias in the assessment of HIV-1 seropositive persons: a WHO study. Arch Clin Neuropsychol. 1993;8(2):123-135. http://www.ncbi.nlm.nih.gov/pubmed/14589670 Accessed April 16, 2020
Wechsler D. Wechsler Intelligence Scale for Children-- Revised, UK Edition. NFER-Nelson; 1976.
Wilson BA, Alderman N, Burgess PW, Emslie H, Evans JJ. BADS: Behavioural Assessment of the Dysexecutive Syndrome. Thames Valley Test Company; 1996.
Royall DR, Mahurin RK, Gray KF. Bedside assessment of executive cognitive impairment: the executive interview. J Am Geriatr Soc. 1992;40(12):1221-1226. doi:10.1111/j.1532-5415.1992.tb03646.x
Kaplan E, Goodglass H, Weintraub S. The Boston Naming Test. Lea & Febige; 1983.
Baddeley A, Emslie H, Smith I. The Speed and Capacity of Language Processing (SCOLP) Test: A Manual. Thames Valley Test Co; 1992.
Folstein MF, Folstein SE, McHugh PR. Mini-mental state. J Psychiatr Res. 1975;12(3):189-198. doi:10.1016/0022-3956(75)90026-6
Wells G, Shea B, O’Connell D, Peterson J. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. Ottawa Hospital Research Institute; 2000. http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp Accessed March 28, 2013
Viechtbauer W. Conducting meta-analyses in R with the metafor. J Stat Softw. 2010;36(3):1-48.
Albajes-Eizagirre A, Solanes A, Radua J. Meta-analysis of non-statistically significant unreported effects. Stat Methods Med Res. 2019;28(12):3741-3754. doi:10.1177/0962280218811349
Schouws S, Comijs H, Dols A, Beekman ATF, Stek ML. Five-year follow-up of cognitive impairment in older adults with bipolar disorder. Bipolar Disord. 2016;18(2):148-154. doi:10.1111/bdi.12374
Delaloye C, Moy G, de Bilbao F, et al. Longitudinal analysis of cognitive performances and structural brain changes in late-life bipolar disorder. Int J Geriatr Psychiatry. 2011;26(12):1309-1318. doi:10.1002/gps.2683
Schouws SNTM, Stek ML, Comijs HC, Dols A, Beekman ATF. Cognitive decline in elderly bipolar disorder patients: a follow-up study. Bipolar Disord. 2012;14(7):749-755. doi:10.1111/bdi.12000
Meesters PD, Schouws S, Stek M, et al. Cognitive impairment in late life schizophrenia and bipolar i disorder. Int J Geriatr Psychiatry. 2013;28(1):82-90. doi:10.1002/gps.3793
Schouws SNTM, Comijs HC, Stek ML, Beekman ATF. Self-reported cognitive complaints in elderly bipolar patients. Am J Geriatr Psychiatry. 2012;20(8):700-706. doi:10.1097/JGP.0b013e31822ccd27
Schouws SNTM, Zoeteman JB, Comijs HC, Stek ML, Beekman ATF. Cognitive functioning in elderly patients with early onset bipolar disorder. Int J Geriatr Psychiatry. 2007;22(9):856-861. doi:10.1002/gps.1751
Besga A, Gonzalez I, Echeburua E, et al. Discrimination between Alzheimer’s disease and late onset bipolar disorder using multivariate analysis. Front Aging Neurosci. 2015;7:1-9. doi:10.3389/fnagi.2015.00231
Canuto A, Giannakopoulos P, Moy G, et al. Neurocognitive deficits and personality traits among euthymic patients with mood disorders in late life. J Neurol Sci. 2010;299(1-2):24-29. doi:10.1016/j.jns.2010.08.045
Delaloye C, Moy G, Baudois S, et al. Cognitive features in euthymic bipolar patients in old age. Bipolar Disord. 2009;11(7):735-743. doi:10.1111/j.1399-5618.2009.00741.x
Martino DJ, Igoa A, Marengo E, Scápola M, Ais ED, Strejilevich SA. Cognitive and motor features in elderly people with bipolar disorder. J Affect Disord. 2008;105(1-3):291-295. doi:10.1016/j.jad.2007.05.014
Martino DJ, Marengo E, Igoa A, Strejilevich SA. Neurocognitive heterogeneity in older adults with bipolar disorders. Psychiatry Res. 2017;2018(262):510-512. doi:10.1016/j.psychres.2017.09.035
Schouws SNTM, Comijs HC, Stek ML, et al. Cognitive impairment in early and late bipolar disorder. Am J Geriatr Psychiatry. 2009;17(6):508-515. doi:10.1097/JGP.0b013e31819e2d50
Strejilevich SA, Martino DJ. Cognitive function in adulthood and elderly euthymic bipolar patients: a comparison to test models of cognitive evolution. J Affect Disord. 2013;150(3):1188-1191. doi:10.1016/j.jad.2013.05.012
Schouws SNTM, Stek ML, Comijs HC, Beekman ATF. Risk factors for cognitive impairment in elderly bipolar patients. J Affect Disord. 2010;125(1-3):330-335. doi:10.1016/j.jad.2009.12.004
Martino DJ, Strejilevich SA, Manes F. Neurocognitive functioning in early-onset and late-onset older patients with euthymic bipolar disorder. Int J Geriatr Psychiatry. 2013;28(2):142-148. doi:10.1002/gps.3801
Burdick KE, Russo M, Frangou S, et al. Empirical evidence for discrete neurocognitive subgroups in bipolar disorder: clinical implications. Psychol Med. 2014;44(14):3083-3096. doi:10.1017/S0033291714000439
Solé B, Bonnin CM, Jiménez E, et al. Heterogeneity of functional outcomes in patients with bipolar disorder: a cluster-analytic approach. Acta Psychiatr Scand. 2018;137(6):516-527. doi:10.1111/acps.12871
Leboyer M, Henry C, Paillere-Martinot ML, Bellivier F. Age at onset in bipolar affective disorders: a review. Bipolar Disord. 2005;7(2):111-118. doi:10.1111/j.1399-5618.2005.00181.x
Ljubic N, Ueberberg B, Grunze H, Assion HJ. Treatment of bipolar disorders in older adults: a review. Ann Gen Psychiatry. 2021;20(1):1-11. doi:10.1186/s12991-021-00367-x
Dols A, Beekman A. Older age bipolar disorder. Clin Geriatr Med. 2020;36(2):281-296. doi:10.1016/j.cger.2019.11.008
Whiteside DM, Kealey T, Semla M, et al. Verbal fluency: language or executive function measure? Appl Neuropsychol Adult. 2016;23(1):29-34. doi:10.1080/23279095.2015.1004574
Radanovic M, Nunes PV, Gattaz WF, Forlenza OV. Language impairment in euthymic, elderly patients with bipolar disorder but no dementia. Int Psychogeriatrics. 2008;20(4):687-696. doi:10.1017/S1041610208007084
Mann-Wrobel MC, Carreno JT, Dickinson D. Meta-analysis of neuropsychological functioning in euthymic bipolar disorder: an update and investigation of moderator variables. Bipolar Disord. 2011;13(4):334-342. doi:10.1111/j.1399-5618.2011.00935.x
Bourne C, Aydemir Ö, Balanzá-Martínez V, et al. Neuropsychological testing of cognitive impairment in euthymic bipolar disorder: an individual patient data meta-analysis. Acta Psychiatr Scand. 2013;128(3):149-162. doi:10.1111/acps.12133
Beunders AJM, Kemp T, Korten NCM, et al. Cognitive performance in older-age bipolar disorder: investigating psychiatric characteristics, cardiovascular burden and psychotropic medication. Acta Psychiatr Scand. 2021;144(4):392-406. doi:10.1111/acps.13342
Espanhol JCL, Vieira-Coelho MA. Effects of lithium use on the white matter of patients with bipolar disorder-a systematic review. Nord J Psychiatry. 2021:1-11. doi:10.1080/08039488.2021.1921264
Hajek T, Kopecek M, Höschl C, Alda M. Smaller hippocampal volumes in patients with bipolar disorder are masked by exposure to lithium: a meta-analysis. J Psychiatry Neurosci. 2012;37(5):333-343. doi:10.1503/jpn.110143
Gildengers AG, Butters MA, Aizenstein HJ, et al. Longer lithium exposure is associated with better white matter integrity in older adults with bipolar disorder. Bipolar Disord. 2015;17(3):248-256. doi:10.1111/bdi.12260
Sajatovic M, Forester BP, Gildengers A, Mulsant BH. Aging changes and medical complexity in late-life bipolar disorder: emerging research findings that may help advance care. Neuropsychiatry (London). 2013;3(6):621-633. doi:10.2217/npy.13.78
Malhi GS, Tanious M, Das P, Coulston CM, Berk M. Potential mechanisms of action of lithium in bipolar disorder: current understanding. CNS Drugs. 2013;27(2):135-153. doi:10.1007/s40263-013-0039-0
Lewandowski KE, Sperry SH, Malloy MC, Forester BP. Age as a predictor of cognitive decline in bipolar disorder. Am J Geriatr Psychiatry. 2014;22(12):1462-1468. doi:10.1016/j.jagp.2013.10.002
Seelye A, Thuras P, Doane B, Clason C, VanVoorst W, Urošević S. Steeper aging-related declines in cognitive control processes among adults with bipolar disorders. J Affect Disord. 2018;2019(246):595-602. doi:10.1016/j.jad.2018.12.076
Da Silva J, Gonçalves-Pereira M, Xavier M, Mukaetova-Ladinska EB. Affective disorders and risk of developing dementia: systematic review. Br J Psychiatry. 2013;202(3):177-186. doi:10.1192/bjp.bp.111.101931
Gildengers AG, Mulsant BH, Begley A, et al. The longitudinal course of cognition in older adults with bipolar disorder. Bipolar Disord. 2009;11(7):744-752. doi:10.1111/j.1399-5618.2009.00739.x
Anaya C, Torrent C, Caballero FF, et al. Cognitive reserve in bipolar disorder: relation to cognition, psychosocial functioning and quality of life. Acta Psychiatr Scand. 2016;133(5):386-398. doi:10.1111/acps.12535
Jensen JH, Knorr U, Vinberg M, Kessing LV, Miskowiak KW. Discrete neurocognitive subgroups in fully or partially remitted bipolar disorder: associations with functional abilities. J Affect Disord. 2016;205:378-386. doi:10.1016/j.jad.2016.08.018
Kessing LV, Ziersen SC, Andersen PK, Vinberg M. A nation-wide population-based longitudinal study mapping physical diseases in patients with bipolar disorder and their siblings. J Affect Disord. 2021;282:18-25. doi:10.1016/j.jad.2020.12.072
Lala SV, Sajatovic M. Medical and psychiatric comorbidities among elderly individuals with bipolar disorder: a literature review. J Geriatr Psychiatry Neurol. 2012;25(1):20-25. doi:10.1177/0891988712436683
Sajatovic M, Dols A, Rej S, et al. Bipolar symptoms, somatic burden, and functioning in older-age bipolar disorder: analyses from the global aging & geriatric experiments in bipolar disorder database project. Bipolar Disord. 2021;1-12. doi:10.1111/bdi.13119
Belvederi Murri M, Respino M, Proietti L, et al. Cognitive impairment in late life bipolar disorder: risk factors and clinical outcomes. J Affect Disord. 2019;257:166-172. doi:10.1016/j.jad.2019.07.052
Bora E, Yücel M, Pantelis C. Neurocognitive markers of psychosis in bipolar disorder: a meta-analytic study. J Affect Disord. 2010;127(1-3):1-9. doi:10.1016/j.jad.2010.02.117
Cardoso T, Bauer I, Meyer T, Kapczinski F, Soares J. Neuroprogression and cognitive functioning in bipolar disorder: a systematic review. Curr Psychiatry Rep. 2015;17(9). doi:10.1007/S11920-015-0605-X
Vieta E, Angst J. Bipolar disorder cohort studies: crucial, but underfunded. Eur Neuropsychopharmacol. 2021;47:31-33. doi:10.1016/j.euroneuro.2021.03.008
Amoretti S, Ramos-Quiroga JA. Cognitive reserve in mental disorders. Eur Neuropsychopharmacol. 2021;49:113-115. doi:10.1016/j.euroneuro.2021.04.011
Dols A, Kessing LV, Strejilevich SA, et al. Do current national and international guidelines have specific recommendations for older adults with bipolar disorder? A brief report. Int J Geriatr Psychiatry. 2016;31(12):1295-1300. doi:10.1002/gps.4534
Carvalho AF, Firth J, Vieta E. Bipolar disorder. N Engl J Med. 2020;383(1):58-66. doi:10.1056/NEJMra1906193
Forcada I, Mur M, Mora E, Vieta E, Bartrés-Faz D, Portella MJ. The influence of cognitive reserve on psychosocial and neuropsychological functioning in bipolar disorder. Eur Neuropsychopharmacol. 2015;25(2):214-222. doi:10.1016/j.euroneuro.2014.07.018
Amoretti S, Rosa AR, Mezquida G, et al. The impact of cognitive reserve, cognition and clinical symptoms on psychosocial functioning in first-episode psychoses. Psychol Med. 2020:1-12. doi:10.1017/S0033291720002226
Fullerton JM, Nurnberger JI. Polygenic risk scores in psychiatry: will they be useful for clinicians? F1000Research. 2019;8. doi:10.12688/f1000research.18491.1