The effect of isotretinoin on meibomian glands in eyes: a pilot study.
Acne vulgaris
Dry eye disease
Meibography
Meibomian gland dysfunction
İsotretinoin
Journal
International ophthalmology
ISSN: 1573-2630
Titre abrégé: Int Ophthalmol
Pays: Netherlands
ID NLM: 7904294
Informations de publication
Date de publication:
Jul 2022
Jul 2022
Historique:
received:
10
11
2020
accepted:
24
12
2021
pubmed:
4
1
2022
medline:
20
7
2022
entrez:
3
1
2022
Statut:
ppublish
Résumé
The aim of this pilot study was to quantify the meibography changes in patients administered with oral isotretinoin. This prospective pilot study included 30 eyes of 30 patients who received oral isotretinoin treatment due to acne. Each patient underwent a general ophthalmological examination. After fluorescence staining of the ocular surface, the tear film break-up time (TFBUT) test, meibography and Schirmer test were carried out and noted. All of these procedures were applied before the treatment and repeated at 1, 3, and 6 months after the treatment. The percentage of upper meibomian gland (MG) loss at 3 and 6 months after the treatment was 22.2% (p = 0.001) and 23.6% (p = 0.001), respectively. The percentage of lower MG loss at 3 and 6 months after the treatment was 18.7% (p = 0.001) and 20.7% (p = 0.001), respectively. The corneal fluorescein staining score at 3 and 6 months after treatment was 0.57 (p = 0.001), and 0.47 (p = 0.012), respectively. These findings show that oral isotretionin treatment may affect MG morphology. The study findings also suggest that isotretinoin may cause tear film instability with Meibomian gland dysfunction and may cause evaporative type of dryness.
Identifiants
pubmed: 34978652
doi: 10.1007/s10792-021-02205-1
pii: 10.1007/s10792-021-02205-1
doi:
Substances chimiques
Isotretinoin
EH28UP18IF
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2071-2078Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Nature B.V.
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