Repurposing potential of rimantadine hydrochloride and development of a promising platinum(II)-rimantadine metallodrug for the treatment of Chikungunya virus infection.
Antiviral
Chikungunya virus
Drug Repurposing
Platinum(II) metallodrugs
Rimantadine
Journal
Acta tropica
ISSN: 1873-6254
Titre abrégé: Acta Trop
Pays: Netherlands
ID NLM: 0370374
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
received:
29
09
2021
revised:
23
12
2021
accepted:
29
12
2021
pubmed:
4
1
2022
medline:
16
3
2022
entrez:
3
1
2022
Statut:
ppublish
Résumé
Most of the patients infected with Chikungunya virus (CHIKV) develop chronic manifestations characterized by pain and deformity in joints, impacting their quality of life. The aminoadamantanes, in their turn, have been exploited due to their biological activities, with amantadine and memantine recently described with anti-CHIKV activities. Here we evaluated the antiviral activity of rimantadine hydrochloride (rtdH), a well-known antiviral agent against influenza A, its platinum complex (Pt-rtd), and the precursor cis-[PtCl
Identifiants
pubmed: 34979144
pii: S0001-706X(21)00478-2
doi: 10.1016/j.actatropica.2021.106300
pii:
doi:
Substances chimiques
Rimantadine
0T2EF4JQTU
Platinum
49DFR088MY
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
106300Informations de copyright
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