TSPAN1, a novel tetraspanin member highly involved in carcinogenesis and chemoresistance.
Chemoresistance
Metastases
TSPAN1
Tetraspanins
cancer
Journal
Biochimica et biophysica acta. Reviews on cancer
ISSN: 1879-2561
Titre abrégé: Biochim Biophys Acta Rev Cancer
Pays: Netherlands
ID NLM: 9806362
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
received:
08
11
2021
revised:
22
12
2021
accepted:
27
12
2021
pubmed:
4
1
2022
medline:
26
4
2022
entrez:
3
1
2022
Statut:
ppublish
Résumé
The tetraspanin (TSPAN) family constitutes a poorly explored family of membrane receptors involved in various physiological processes, with relevant roles in anchoring multiple proteins, acting as scaffolding proteins, and cell signaling. Recent studies have increasingly demonstrated the involvement of TSPANs in cancer. In particular, tetraspanin 1 (also known as TSPAN1, NET-1, TM4C, C4.8 or GEF) has been implicated in cell survival, proliferation and invasion. Recently, our laboratory revealed a key role of TSPAN1 in the acquired resistance of tumor cells to conventional chemotherapy (e.g., cisplatin). In this review, we summarize and discuss the latest research on the physiological mechanisms of TSPANs in cancer and, in particular, on TSPAN1 regulating resistance to chemotherapy. A model of TSPAN1 action is proposed, and the potential of targeting TSPAN1 in anticancer therapeutic strategies is discussed.
Identifiants
pubmed: 34979155
pii: S0304-419X(21)00172-4
doi: 10.1016/j.bbcan.2021.188674
pii:
doi:
Substances chimiques
TSPAN1 protein, human
0
Tetraspanins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
188674Informations de copyright
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