A combination of Vitreoscilla filiformis extract and Vichy volcanic mineralizing water strengthens the skin defenses and skin barrier.


Journal

Journal of the European Academy of Dermatology and Venereology : JEADV
ISSN: 1468-3083
Titre abrégé: J Eur Acad Dermatol Venereol
Pays: England
ID NLM: 9216037

Informations de publication

Date de publication:
Jan 2022
Historique:
revised: 03 09 2021
received: 02 07 2021
accepted: 27 09 2021
entrez: 3 1 2022
pubmed: 4 1 2022
medline: 6 1 2022
Statut: ppublish

Résumé

Probiotics are live microorganisms, which, when administered in adequate amounts, confer a health benefit on the host. Semiactive, non-replicating bacteria or extracts used in dermocosmetics have interesting properties for skin quality. Vitreoscilla filiformis is cultured by a fermentation process to obtain an extract. It is considered as a probiotic fraction and topical application of this extract has shown activity to strengthen the skin physical barrier function and maintain good homeostasis of skin defenses. Vichy volcanic mineralizing water (VVMW) is a pure, highly mineralized water that has been shown to strengthen the skin against exposome aggressions. This manuscript reviews properties of probiotic fractions used in skin care, especially studies on an extract of V. filiformis grown in a medium containing VVMW (VfeV) and evaluated in combination with VVMW. Skin barrier function: In normal human epidermal keratinocyte cultures, the combination of 10% VVMW and 0.002% VfeV significantly increased transglutaminase, filaggrin, involucrin, claudin-1, and zonula occludens-1 in comparison with the controls. Antimicrobial peptide defenses: The combination of 16.7% VVMW and 0.1% VfeV increased the expression of β-defensin-4A and S100A7. Skin immune defense functions: In lipopolysaccharide-stimulated peripheral blood mononuclear cells, the combination of 16.7% VVMW and 0.1% VfeV down-regulated IL-8, TNF-α, IL-12/IL-23p40, and increased IL10 and IL-10/IL-12 ratio compared to the control. Additionally, the combination of 79% VVMW plus 5% VfeV protected Langerhans cells in skin explants exposed to ultraviolet radiation. In conclusion, the combination of VfeV plus VVMW has properties to strengthen the skin barrier by stimulating skin differentiation and tight junctions, biochemical defenses by stimulating antimicrobial peptides, and cellular immune defenses by increasing the IL-10/IL-12 ratio and by protecting Langerhans cells challenged by ultraviolet radiation.

Identifiants

pubmed: 34979591
doi: 10.1111/jdv.17786
doi:

Substances chimiques

Antimicrobial Peptides 0
Filaggrin Proteins 0
Plant Extracts 0
Water 059QF0KO0R

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

16-25

Subventions

Organisme : Vichy Laboratories (L'Oréal)

Informations de copyright

© 2021 European Academy of Dermatology and Venereology.

Références

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Auteurs

A Gueniche (A)

L'Oréal Research & Innovation, Chevilly Larue, France.

A Valois (A)

L'Oréal Research & Innovation, Chevilly Larue, France.

D Kerob (D)

Laboratoires Vichy, Levallois Perret, France.

V Rasmont (V)

Laboratoires Vichy, Levallois Perret, France.

M Nielsen (M)

Laboratoires Vichy, Levallois Perret, France.

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