Neural responses to affective speech, including motherese, map onto clinical and social eye tracking profiles in toddlers with ASD.
Journal
Nature human behaviour
ISSN: 2397-3374
Titre abrégé: Nat Hum Behav
Pays: England
ID NLM: 101697750
Informations de publication
Date de publication:
03 2022
03 2022
Historique:
received:
21
10
2020
accepted:
22
10
2021
pubmed:
5
1
2022
medline:
20
4
2022
entrez:
4
1
2022
Statut:
ppublish
Résumé
Affective speech, including motherese, captures an infant's attention and enhances social, language and emotional development. Decreased behavioural response to affective speech and reduced caregiver-child interactions are early signs of autism in infants. To understand this, we measured neural responses to mild affect speech, moderate affect speech and motherese using natural sleep functional magnetic resonance imaging and behavioural preference for motherese using eye tracking in typically developing toddlers and those with autism. By combining diverse neural-clinical data using similarity network fusion, we discovered four distinct clusters of toddlers. The autism cluster with the weakest superior temporal responses to affective speech and very poor social and language abilities had reduced behavioural preference for motherese, while the typically developing cluster with the strongest superior temporal response to affective speech showed the opposite effect. We conclude that significantly reduced behavioural preference for motherese in autism is related to impaired development of temporal cortical systems that normally respond to parental affective speech.
Identifiants
pubmed: 34980898
doi: 10.1038/s41562-021-01237-y
pii: 10.1038/s41562-021-01237-y
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
443-454Subventions
Organisme : NIDCD NIH HHS
ID : R01 DC016385
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH104446
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH118879
Pays : United States
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Nature Limited.
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