Inter-fraction dynamics during post-operative 5 fraction cavity hypofractionated stereotactic radiotherapy with a MR LINAC: a prospective serial imaging study.
Adaptive radiotherapy
Brain metastases
Hypofractionated stereotactic radiotherapy
Magnetic resonance image-guided radiotherapy
Journal
Journal of neuro-oncology
ISSN: 1573-7373
Titre abrégé: J Neurooncol
Pays: United States
ID NLM: 8309335
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
received:
30
10
2021
accepted:
27
12
2021
pubmed:
5
1
2022
medline:
30
3
2022
entrez:
4
1
2022
Statut:
ppublish
Résumé
This study examined changes in the clinical target volume (CTV) and associated clinical implications on a magnetic resonance imaging linear accelerator (MR LINAC) during hypofractionated stereotactic radiotherapy (HSRT) to resected brain metastases. In addition, the suitability of using T2/FLAIR (T2f) sequence to define CTV was explored by assessing contouring variability between gadolinium-enhanced T1 (T1c) and T2f sequences. Fifteen patients treated to either 27.5 or 30 Gy with five fraction HSRT were imaged with T1c and T2f sequences during treatment; T1c was acquired at planning (FxSim), and fraction 3 (Fx3), and T2f was acquired at FxSim and all five fractions. The CTV were contoured on all acquired images. Inter-fraction cavity dynamics and CTV contouring variability were quantified using absolute volume, Dice similarity coefficient (DSC), and Hausdorff distance (HD) metrics. The median CTV on T1c and T2f sequences at FxSim were 12.0cm Statistically significant reductions in cavity CTV was observed during HSRT, supporting the use of MR image guided radiation therapy and treatment adaptation to mitigate toxicity. Significant CTV contouring variability was seen between T1c and T2f sequences. Trial registration NCT04075305 - August 30, 2019.
Identifiants
pubmed: 34981300
doi: 10.1007/s11060-021-03938-w
pii: 10.1007/s11060-021-03938-w
doi:
Banques de données
ClinicalTrials.gov
['NCT04075305']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
569-577Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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