The Multifaceted Actions of Curcumin in Obesity.
Adiposity
Curcumin
Inflammation
Metabolism
Journal
Advances in experimental medicine and biology
ISSN: 0065-2598
Titre abrégé: Adv Exp Med Biol
Pays: United States
ID NLM: 0121103
Informations de publication
Date de publication:
2021
2021
Historique:
entrez:
4
1
2022
pubmed:
5
1
2022
medline:
6
1
2022
Statut:
ppublish
Résumé
Obesity remains a pervasive health concern worldwide with concomitant comorbidities such as cardiovascular diseases, diabetes, inflammation, and other metabolic disorders. A wealth of data validates dietary and lifestyle modifications such as restricting caloric intake and increasing physical activity to slow the obesity development. Recently, the advent of phytochemicals such as curcumin, the active ingredient in turmeric, has attracted considerable research interest in tracking down their possible effects in protection against obesity and obesity-related comorbidities. According to the existing literature, curcumin may regulate lipid metabolism and suppress chronic inflammation interacting with white adipose tissue, which plays a central role in the complications associated with obesity. Curcumin also inhibits the differentiation of adipocyte and improves antioxidant properties. In the present review, we sought to deliberate the possible effects of curcumin in downregulating obesity and curtailing the adverse health effects of obesity.
Identifiants
pubmed: 34981472
doi: 10.1007/978-3-030-73234-9_6
doi:
Substances chimiques
Curcumin
IT942ZTH98
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
81-97Informations de copyright
© 2021. The Author(s), under exclusive license to Springer Nature Switzerland AG.
Références
Karageorgi, S., Alsmadi, O., & Behbehani, K. (2013). A review of adult obesity prevalence, trends, risk factors, and epidemiologic methods in Kuwait. Journal of Obesity, 2013.
Haidar, Y. M., & Cosman, B. C. (2011). Obesity epidemiology. Clinics in Colon and Rectal Surgery, 24(4), 205.
pubmed: 23204935
pmcid: 3311487
WHO. (2014). Global Status Report on Noncommunicable Diseases, 2014.
Ogden, C. L., Carroll, M. D., Fryar, C. D., & Flegal, K. M. (2015). Prevalence of obesity among adults and youth: United States, 2011–2014. US Department of Health and Human Services, Centers for Disease Control and ….
Arroyo-Johnson, C., & Mincey, K. D. (2016). Obesity epidemiology worldwide. Gastroenterology Clinics, 45(4), 571–579.
pubmed: 27837773
Bastien, M., Poirier, P., Lemieux, I., & Després, J.-P. (2014). Overview of epidemiology and contribution of obesity to cardiovascular disease. Progress in Cardiovascular Diseases, 56(4), 369–381.
pubmed: 24438728
Collaboration PS. (2009). Body-mass index and cause-specific mortality in 900 000 adults: Collaborative analyses of 57 prospective studies. The Lancet, 373(9669), 1083–1096.
Mandviwala, T., Khalid, U., & Deswal, A. (2016). Obesity and cardiovascular disease: A risk factor or a risk marker? Current Atherosclerosis Reports, 18(5), 21.
pubmed: 26973130
Poirier, P., Giles, T. D., Bray, G. A., Hong, Y., Stern, J. S., Pi-Sunyer, F. X., et al. (2006). Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss: An update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease from the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism. Circulation, 113(6), 898–918.
pubmed: 16380542
Akin, I., & Nienaber, C. A. (2015). “Obesity paradox” in coronary artery disease. World Journal of Cardiology, 7(10), 603.
pubmed: 26516414
pmcid: 4620071
Alberti, K. G. M., Zimmet, P., & Shaw, J. (2005). The metabolic syndrome—A new worldwide definition. The Lancet, 366(9491), 1059–1062.
van Vliet-Ostaptchouk, J. V., Nuotio, M.-L., Slagter, S. N., Doiron, D., Fischer, K., Foco, L., et al. (2014). The prevalence of metabolic syndrome and metabolically healthy obesity in Europe: A collaborative analysis of ten large cohort studies. BMC Endocrine Disorders, 14(1), 9.
pubmed: 24484869
pmcid: 3923238
Mozumdar, A., & Liguori, G. (2011). Persistent increase of prevalence of metabolic syndrome among US adults: NHANES III to NHANES 1999–2006. Diabetes Care, 34(1), 216–219.
pubmed: 20889854
Ford, E. S., Giles, W. H., & Dietz, W. H. (2002). Prevalence of the metabolic syndrome among US adults: Findings from the third National Health and Nutrition Examination Survey. JAMA, 287(3), 356–359.
pubmed: 11790215
Hossain P, Kawar B, El Nahas M. (2007) Obesity and diabetes in the developing world–a growing challenge. N Engl J Med. 356(3), 213–215.
Felber, J., & Golay, A. (2002). Pathways from obesity to diabetes. International Journal of Obesity, 26(S2), S39.
pubmed: 12174327
Han, T. S., & Lean, M. E. (2016). A clinical perspective of obesity, metabolic syndrome and cardiovascular disease. JRSM Cardiovascular Disease, 52048004016633371.
Fabbrini, E., Sullivan, S., & Klein, S. (2010). Obesity and nonalcoholic fatty liver disease: Biochemical, metabolic, and clinical implications. Hepatology, 51(2), 679–689.
pubmed: 20041406
Bellentani, S., Saccoccio, G., Masutti, F., Crocè, L. S., Brandi, G., Sasso, F., et al. (2000). Prevalence of and risk factors for hepatic steatosis in Northern Italy. Annals of Internal Medicine, 132(2), 112–117.
pubmed: 10644271
Angulo, P. (2002). Nonalcoholic fatty liver disease. New England Journal of Medicine, 346(16), 1221–1231.
pubmed: 11961152
Santos, R. D., & Agewall, S. (2012). Non-alcoholic fatty liver disease and cardiovascular disease. Atherosclerosis, 224(2), 324–325.
pubmed: 22840429
Schwartz, A. R., Patil, S. P., Laffan, A. M., Polotsky, V., Schneider, H., & Smith, P. L. (2008). Obesity and obstructive sleep apnea: Pathogenic mechanisms and therapeutic approaches. Proceedings of the American Thoracic Society, 5(2), 185–192.
pubmed: 18250211
pmcid: 2645252
Young, T., Palta, M., Dempsey, J., Skatrud, J., Weber, S., & Badr, S. (1993). The occurrence of sleep-disordered breathing among middle-aged adults. New England Journal of Medicine, 328(17), 1230–1235.
pubmed: 8464434
Vats, M. G., Mahboub, B. H., Al Hariri, H., Al Zaabi, A., & Vats, D. (2016). Obesity and Sleep-Related Breathing Disorders in Middle East and UAE. Canadian Respiratory Journal, 2016.
Escobar-Morreale, H. F., Botella-Carretero, J. I., Alvarez-Blasco, F., Sancho, J., & San Millán, J. L. (2005). The polycystic ovary syndrome associated with morbid obesity may resolve after weight loss induced by bariatric surgery. The Journal of Clinical Endocrinology & Metabolism, 90(12), 6364–6369.
Percik, R., & Stumvoll, M. (2009). Obesity and cancer. Experimental and Clinical Endocrinology & Diabetes, 117(10), 563–566.
De Pergola, G., & Silvestris, F. (2013). Obesity as a major risk factor for cancer. Journal of Obesity, 2013.
Pearce, E. N. (2012). Thyroid hormone and obesity. Current Opinion in Endocrinology, Diabetes and Obesity, 19(5), 408–413.
Tiryakioglu, O., Ugurlu, S., Yalin, S., Yirmibescik, S., Caglar, E., Yetkin, D. O., et al. (2010). Screening for Cushing’s syndrome in obese patients. Clinics, 65(1), 9–13.
pubmed: 20126340
pmcid: 2815288
Gibson-Smith, D., Bot, M., Paans, N. P., Visser, M., Brouwer, I., & Penninx, B. W. (2016). The role of obesity measures in the development and persistence of major depressive disorder. Journal of Affective Disorders, 198, 222–229.
Anandacoomarasamy, A., Caterson, I., Sambrook, P., Fransen, M., & March, L. (2008). The impact of obesity on the musculoskeletal system. International Journal of Obesity, 32(2), 211.
pubmed: 17848940
Coggon, D., Reading, I., Croft, P., McLaren, M., Barrett, D., & Cooper, C. (2001). Knee osteoarthritis and obesity. International Journal of Obesity, 25(5), 622.
pubmed: 11360143
King, L. K., March, L., & Anandacoomarasamy, A. (2013). Obesity & osteoarthritis. The Indian Journal of Medical Research, 138(2), 185.
pubmed: 24056594
pmcid: 3788203
Mathis, D., & Shoelson, S. E. (2011). Immunometabolism: An emerging frontier. Nature Reviews Immunology, 11(2), 81.
pubmed: 21469396
pmcid: 4784680
Stienstra, R., Tack, C. J., Kanneganti, T.-D., Joosten, L. A., & Netea, M. G. (2012). The inflammasome puts obesity in the danger zone. Cell Metabolism, 15(1), 10–18.
pubmed: 22225872
Anderson, E. K., Gutierrez, D. A., & Hasty, A. H. (2010). Adipose tissue recruitment of leukocytes. Current Opinion in Lipidology, 21(3), 172.
pubmed: 20410821
pmcid: 3381420
Meijer, K., de Vries, M., Al-Lahham, S., Bruinenberg, M., Weening, D., Dijkstra, M., et al. (2011). Human primary adipocytes exhibit immune cell function: Adipocytes prime inflammation independent of macrophages. PLoS One, 6(3), e17154.
pubmed: 21448265
pmcid: 3063154
Rodríguez-Hernández, H., Simental-Mendía, L. E., Rodríguez-Ramírez, G., & Reyes-Romero, M. A. (2013). Obesity and inflammation: epidemiology, risk factors, and markers of inflammation. International Journal of Endocrinology, 2013.
Surmi, B., & Hasty, A. (2008). Macrophage infiltration into adipose tissue: Initiation, propagation and remodeling. Future Lipidology, 3(5), 545–556.
pubmed: 18978945
pmcid: 2575346
Bai, Y., & Sun, Q. (2015). Macrophage recruitment in obese adipose tissue. Obesity Reviews, 16(2), 127–136.
pubmed: 25586506
pmcid: 4304983
Ray, I., Mahata, S. K., & De, R. K. (2016). Obesity: An immunometabolic perspective. Frontiers in Endocrinology, 7157.
McPhee, J. B., & Schertzer, J. D. (2015). Immunometabolism of obesity and diabetes: Microbiota link compartmentalized immunity in the gut to metabolic tissue inflammation. Clinical Science, 129(12), 1083–1096.
pubmed: 26464517
Klop, B., Elte, J. W. F., & Cabezas, M. C. (2013). Dyslipidemia in obesity: Mechanisms and potential targets. Nutrients, 5(4), 1218–1240.
pubmed: 23584084
pmcid: 3705344
Feingold KR. Obesity and Dyslipidemia. [Updated 2020 Nov 2]. In: Feingold KR, Anawalt B, Boyce A, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK305895/
Hardy, O. T., Czech, M. P., & Corvera, S. (2012). What causes the insulin resistance underlying obesity? Current Opinion in Endocrinology, Diabetes, and Obesity, 19(2), 81.
pubmed: 22327367
pmcid: 4038351
Castro, A. V. B., Kolka, C. M., Kim, S. P., & Bergman, R. N. (2014). Obesity, insulin resistance and comorbidities? Mechanisms of association. Arquivos Brasileiros de Endocrinologia & Metabologia, 58(6), 600–609.
Carlson, O. D., David, J. D., Schrieder, J. M., Muller, D. C., Jang, H.-J., Kim, B.-J., et al. (2007). Contribution of nonesterified fatty acids to insulin resistance in the elderly with normal fasting but diabetic 2-hour postchallenge plasma glucose levels: The Baltimore Longitudinal Study of Aging. Metabolism, 56(10), 1444–1451.
pubmed: 17884459
pmcid: 2084355
Karpe, F., Dickmann, J. R., & Frayn, K. N. (2011). Fatty acids, obesity, and insulin resistance: Time for a reevaluation. Diabetes, 60(10), 2441–2449.
pubmed: 21948998
pmcid: 3178283
Abdollahi, E., Momtazi, A. A., Johnston, T. P., & Sahebkar, A. (2018). Therapeutic effects of curcumin in inflammatory and immune-mediated diseases: A nature-made jack-of-all-trades? Journal of Cellular Physiology, 233(2), 830–848.
pubmed: 28059453
Iranshahi, M., Sahebkar, A., Hosseini, S. T., Takasaki, M., Konoshima, T., & Tokuda, H. (2010). Cancer chemopreventive activity of diversin from Ferula diversivittata in vitro and in vivo. Phytomedicine, 17(3–4), 269–273.
pubmed: 19577457
Mollazadeh, H., Cicero, A. F. G., Blesso, C. N., Pirro, M., Majeed, M., & Sahebkar, A. (2019). Immune modulation by curcumin: The role of interleukin-10. Critical Reviews in Food Science and Nutrition, 59(1), 89–101.
pubmed: 28799796
Momtazi, A. A., Derosa, G., Maffioli, P., Banach, M., & Sahebkar, A. (2016). Role of microRNAs in the Therapeutic Effects of Curcumin in Non-Cancer Diseases. Molecular Diagnosis and Therapy, 20(4), 335–345.
pubmed: 27241179
Panahi, Y., Ahmadi, Y., Teymouri, M., Johnston, T.P., Sahebkar, A. (2018). Curcumin as a potential candidate for treating hyperlipidemia: A review of cellular and metabolic mechanisms. Journal of Cellular Physiology, 233(1), 141–152.
Ghandadi, M., Sahebkar, A. (2017) Curcumin: An effective inhibitor of interleukin-6. Current Pharmaceutical Design, 23(6), 921–931.
Panahi, Y., Khalili, N., Sahebi, E., Namazi, S., Simental-Mendía, L.E., Majeed, M., Sahebkar, A. (2018) Effects of curcuminoids plus piperine on glycemic, hepatic and inflammatory biomarkers in patients with type 2 diabetes Mellitus: a randomized double-blind placebo-controlled trial. Drug Research, 68(7), 403–409.
Teymouri, M., Pirro, M., Johnston, T. P., & Sahebkar, A. (2017). Curcumin as a multifaceted compound against human papilloma virus infection and cervical cancers: A review of chemistry, cellular, molecular, and preclinical features. BioFactors, 43(3), 331–346.
pubmed: 27896883
Johnston, T. P., Korolenko, T. A., Pirro, M., & Sahebkar, A. (2017). Preventing cardiovascular heart disease: Promising nutraceutical and non-nutraceutical treatments for cholesterol management. Pharmacological Research, 120, 219–225.
Bradford, P. G. (2013). Curcumin and obesity. BioFactors, 39(1), 78–87.
pubmed: 23339049
Aggarwal, B. B. (2010). Targeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals. Annual Review of Nutrition, 30, 173–199.
Shehzad, A., Khan, S., & Sup Lee, Y. (2012). Curcumin molecular targets in obesity and obesity-related cancers. Future Oncology, 8(2), 179–190.
pubmed: 22335582
Mohamed, G. A., Ibrahim, S. R., Elkhayat, E. S., & El Dine, R. S. (2014). Natural anti-obesity agents. Bulletin of Faculty of Pharmacy, Cairo University, 52(2), 269–284.
Shehzad, A., Ha, T., Subhan, F., & Lee, Y. S. (2011). New mechanisms and the anti-inflammatory role of curcumin in obesity and obesity-related metabolic diseases. European Journal of Nutrition, 50(3), 151–161.
pubmed: 21442412
Arkan, M. C., Hevener, A. L., Greten, F. R., Maeda, S., Li, Z.-W., Long, J. M., et al. (2005). IKK-β links inflammation to obesity-induced insulin resistance. Nature Medicine, 11(2), 191.
pubmed: 15685170
Aggarwal, B. B., Gupta, S. C., & Sung, B. (2013). Curcumin: An orally bioavailable blocker of TNF and other pro-inflammatory biomarkers. British Journal of Pharmacology, 169(8), 1672–1692.
pubmed: 23425071
pmcid: 3753829
Shishodia, S. (2013). Molecular mechanisms of curcumin action: Gene expression. BioFactors, 39(1), 37–55.
pubmed: 22996381
Jobin, C., Bradham, C. A., Russo, M. P., Juma, B., Narula, A. S., Brenner, D. A., et al. (1999). Curcumin blocks cytokine-mediated NF-κB activation and proinflammatory gene expression by inhibiting inhibitory factor I-κB kinase activity. The Journal of Immunology, 163(6), 3474–3483.
pubmed: 10477620
Shao, W., Yu, Z., Chiang, Y., Yang, Y., Chai, T., Foltz, W., et al. (2012). Curcumin prevents high fat diet induced insulin resistance and obesity via attenuating lipogenesis in liver and inflammatory pathway in adipocytes. PLoS One, 7(1), e28784.
pubmed: 22253696
pmcid: 3253779
Laurencikiene, J., Van Harmelen, V., Nordström, E. A., Dicker, A., Blomqvist, L., Näslund, E., et al. (2007). NF-κB is important for TNF-α-induced lipolysis in human adipocytes. Journal of Lipid Research, 48(5), 1069–1077.
pubmed: 17272828
Gonzales, A. M., & Orlando, R. A. (2008). Curcumin and resveratrol inhibit nuclear factor-kappaB-mediated cytokine expression in adipocytes. Nutrition & metabolism, 5(1), 17.
Ghoshal, S., Trivedi, D. B., Graf, G. A., & Loftin, C. D. (2011). Cyclooxygenase-2 deficiency attenuates adipose tissue differentiation and inflammation in mice. Journal of Biological Chemistry, 286(1), 889–898.
pubmed: 20961858
Hsieh, P. S., Jin, J. S., Chiang, C. F., Chan, P. C., Chen, C. H., & Shih, K. C. (2009). COX-2-mediated inflammation in fat is crucial for obesity-linked insulin resistance and fatty liver. Obesity, 17(6), 1150–1157.
pubmed: 19247274
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993). Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance. Science, 259(5091), 87–91.
pubmed: 7678183
Hofmann, C., Lorenz, K., Braithwaite, S., Colca, J., Palazuk, B., Hotamisligil, G., et al. (1994). Altered gene expression for tumor necrosis factor-alpha and its receptors during drug and dietary modulation of insulin resistance. Endocrinology, 134(1), 264–270.
pubmed: 8275942
Kern, P. A., Saghizadeh, M., Ong, J. M., Bosch, R. J., Deem, R., & Simsolo, R. B. (1995). The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase. The Journal of Clinical Investigation, 95(5), 2111–2119.
pubmed: 7738178
pmcid: 295809
Hotamisligil, G. S., Arner, P., Caro, J. F., Atkinson, R. L., & Spiegelman, B. M. (1995). Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. The Journal of Clinical Investigation, 95(5), 2409–2415.
pubmed: 7738205
pmcid: 295872
Woo, H.-M., Kang, J.-H., Kawada, T., Yoo, H., Sung, M.-K., & Yu, R. (2007). Active spice-derived components can inhibit inflammatory responses of adipose tissue in obesity by suppressing inflammatory actions of macrophages and release of monocyte chemoattractant protein-1 from adipocytes. Life Sciences, 80(10), 926–931.
pubmed: 17196622
Yekollu, S. K., Thomas, R., & O’sullivan, B. (2011). Targeting curcusomes to inflammatory dendritic cells inhibits NF-κB and improves insulin resistance in obese mice. Diabetes, 60(11), 2928–2938.
pubmed: 21885868
pmcid: 3198103
He, Z.-Y., Shi, C.-B., Wen, H., Li, F.-L., Wang, B.-L., & Wang, J. (2011). Upregulation of p53 expression in patients with colorectal cancer by administration of curcumin. Cancer Investigation, 29(3), 208–213.
pubmed: 21314329
Usharani, P., Mateen, A., Naidu, M., Raju, Y., & Chandra, N. (2008). Effect of NCB-02, atorvastatin and placebo on endothelial function, oxidative stress and inflammatory markers in patients with type 2 diabetes mellitus. Drugs in R & D, 9(4), 243–250.
Xydakis, A. M., Case, C. C., Jones, P. H., Hoogeveen, R. C., Liu, M.-Y., EOb, S., et al. (2004). Adiponectin, inflammation, and the expression of the metabolic syndrome in obese individuals: the impact of rapid weight loss through caloric restriction. The Journal of Clinical Endocrinology & Metabolism, 89(6), 2697–2703.
Lee, H.-S., Lee, M.-S., & Joung, H.-J. (2007). Adiponectin represents an independent risk factor for hypertension in middle aged Korean women. Asia Pacific Journal of Clinical Nutrition, 16(1), 10–15.
pubmed: 17215175
Panahi, Y., Hosseini, M. S., Khalili, N., Naimi, E., Soflaei, S. S., Majeed, M., et al. (2016). Effects of supplementation with curcumin on serum adipokine concentrations: A randomized controlled trial. Nutrition, 32(10), 1116–1122.
pubmed: 27297718
Qu, X., Zhao, S., Xu, J., & Dong, L. (2008). Effects of curcumin on secretion of adiponectin and interleukin-6 in human adipose tissues: an in vitro study. Zhong xi yi jie he xue bao = Journal of Chinese Integrative Medicine, 6(7), 711–715.
pubmed: 18601853
Song, W.-Y., & Choi, J.-H. (2016). Korean Curcuma longa L. induces lipolysis and regulates leptin in adipocyte cells and rats. Nutrition Research and Practice, 10(5), 487–493.
pubmed: 27698955
pmcid: 5037065
Karimian, M. S., Pirro, M., Majeed, M., & Sahebkar, A. (2017). Curcumin as a natural regulator of monocyte chemoattractant protein-1. Cytokine & Growth Factor Reviews, 33, 55–63.
Alappat, L., & Awad, A. B. (2010). Curcumin and obesity: Evidence and mechanisms. Nutrition Reviews, 68(12), 729–738.
pubmed: 21091916
Videla, L. A., Tapia, G., Rodrigo, R., Pettinelli, P., Haim, D., Santibañez, C., et al. (2009). Liver NF-κB and AP-1 DNA binding in obese patients. Obesity, 17(5), 973–979.
pubmed: 19165171
Bierhaus, A., Zhang, Y., Quehenberger, P., Luther, T., Haase, M., Müller, M., et al. (1997). The dietary pigment curcumin reduces endothelial tissue factor gene expression by inhibiting binding of AP-1 to the DNA and activation of NF-kappa B. Thrombosis and Haemostasis, 77(4), 772–782.
pubmed: 9134658
Okada, K., Wangpoengtrakul, C., Tanaka, T., Toyokuni, S., Uchida, K., & Osawa, T. (2001). Curcumin and especially tetrahydrocurcumin ameliorate oxidative stress-induced renal injury in mice. The Journal of Nutrition, 131(8), 2090–2095.
pubmed: 11481399
Asai, A., & Miyazawa, T. (2001). Dietary curcuminoids prevent high-fat diet–induced lipid accumulation in rat liver and epididymal adipose tissue. The Journal of Nutrition, 131(11), 2932–2935.
pubmed: 11694621
Jang, E.-M., Choi, M.-S., Jung, U. J., Kim, M.-J., Kim, H.-J., Jeon, S.-M., et al. (2008). Beneficial effects of curcumin on hyperlipidemia and insulin resistance in high-fat–fed hamsters. Metabolism, 57(11), 1576–1583.
pubmed: 18940397
El-Moselhy, M. A., Taye, A., Sharkawi, S. S., El-Sisi, S. F., & Ahmed, A. F. (2011). The antihyperglycemic effect of curcumin in high fat diet fed rats. Role of TNF-α and free fatty acids. Food and Chemical Toxicology, 49(5), 1129–1140.
pubmed: 21310207
Peschel, D., Koerting, R., & Nass, N. (2007). Curcumin induces changes in expression of genes involved in cholesterol homeostasis. The Journal of Nutritional Biochemistry, 18(2), 113–119.
pubmed: 16713233
Mohammadi, A., Sahebkar, A., Iranshahi, M., Amini, M., Khojasteh, R., Ghayour-Mobarhan, M., et al. (2013). Effects of supplementation with curcuminoids on dyslipidemia in obese patients: A randomized crossover trial. Phytotherapy Research, 27(3), 374–379.
pubmed: 22610853
Jiménez-Osorio, A. S., Monroy, A., & Alavez, S. (2016). Curcumin and insulin resistance—Molecular targets and clinical evidences. BioFactors, 42(6), 561–580.
pubmed: 27325504
Goldstein, B. J., Bittner-Kowalczyk, A., White, M. F., & Harbeck, M. (2000). Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein. Journal of Biological Chemistry, 275(6), 4283–4289.
pubmed: 10660596
Li, J. M., Li, Y. C., Kong, L. D., & Hu, Q. H. (2010). Curcumin inhibits hepatic protein-tyrosine phosphatase 1B and prevents hypertriglyceridemia and hepatic steatosis in fructose-fed rats. Hepatology, 51(5), 1555–1566.
pubmed: 20222050
Na, L.-X., Zhang, Y.-L., Li, Y., Liu, L.-Y., Li, R., Kong, T., et al. (2011). Curcumin improves insulin resistance in skeletal muscle of rats. Nutrition, Metabolism and Cardiovascular Diseases, 21(7), 526–533.
pubmed: 20227862
Shao-Ling, W., Ying, L., Ying, W., Yan-Feng, C., Li-Xin, N., Song-Tao, L., et al. (2009). Curcumin, a potential inhibitor of up-regulation of TNF-alpha and IL-6 induced by palmitate in 3T3-L1 adipocytes through NF-kappaB and JNK pathway. Biomedical and Environmental Sciences, 22(1), 32–39.
Weisberg, S. P., Leibel, R., & Tortoriello, D. V. (2008). Dietary curcumin significantly improves obesity-associated inflammation and diabetes in mouse models of diabesity. Endocrinology, 149(7), 3549–3558.
pubmed: 18403477
pmcid: 2453081
Chuengsamarn, S., Rattanamongkolgul, S., Luechapudiporn, R., Phisalaphong, C., & Jirawatnotai, S. (2012). Curcumin extract for prevention of type 2 diabetes. Diabetes Care DC_120116.
Na, L. X., Li, Y., Pan, H. Z., Zhou, X. L., Sun, D. J., Meng, M., et al. (2013). Curcuminoids exert glucose-lowering effect in type 2 diabetes by decreasing serum free fatty acids: A double-blind, placebo-controlled trial. Molecular Nutrition & Food Research, 57(9), 1569–1577.
Christodoulides, C., Lagathu, C., Sethi, J. K., & Vidal-Puig, A. (2009). Adipogenesis and WNT signalling. Trends in Endocrinology & Metabolism, 20(1), 16–24.
Fuster, J. J., Zuriaga, M. A., Ngo, D. T.-M., Farb, M. G., Aprahamian, T., Yamaguchi, T. P., et al. (2015). Noncanonical Wnt signaling promotes obesity-induced adipose tissue inflammation and metabolic dysfunction independent of adipose tissue expansion. Diabetes, 64(4), 1235–1248.
pubmed: 25352637
Ahn, J., Lee, H., Kim, S., & Ha, T. (2010). Curcumin-induced suppression of adipogenic differentiation is accompanied by activation of Wnt/β-catenin signaling. American Journal of Physiology-Cell Physiology, 298(6), C1510–C1516.
pubmed: 20357182
Lone, J., Choi, J. H., Kim, S. W., & Yun, J. W. (2016). Curcumin induces brown fat-like phenotype in 3T3-L1 and primary white adipocytes. The Journal of Nutritional Biochemistry, 27, 193–202.
Ejaz, A., Wu, D., Kwan, P., & Meydani, M. (2009). Curcumin inhibits adipogenesis in 3T3-L1 adipocytes and angiogenesis and obesity in C57/BL mice. The Journal of Nutrition, 139(5), 919–925.
pubmed: 19297423
Zhang, J., Wang, J., Xu, J., Lu, Y., Jiang, J., Wang, L., et al. (2016). Curcumin targets the TFEB-lysosome pathway for induction of autophagy. Oncotarget, 7(46), 75659.
pubmed: 27689333
pmcid: 5342768