Anti-Huntington's Effect of Butin in 3-Nitropropionic Acid-Treated Rats: Possible Mechanism of Action.
Acetylcholinesterase
Butin
Flavonoids
Mitochondrial dysfunction
Neuroprotective
Journal
Neurotoxicity research
ISSN: 1476-3524
Titre abrégé: Neurotox Res
Pays: United States
ID NLM: 100929017
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
received:
13
09
2021
accepted:
09
12
2021
revised:
06
12
2021
pubmed:
5
1
2022
medline:
5
4
2022
entrez:
4
1
2022
Statut:
ppublish
Résumé
Butin has a strong antioxidant plus anti-inflammatory action and it is reported to be protective in oxidative stress-induced mitochondrial dysfunction. Butin has been shown to protect the mouse hippocampus HT22 cells from glutamate-induced neurotoxicity. The current investigation was planned to assess anti-Huntington's effect of butin in 3-nitropropionic acid-treated rats. A total of 32 Wistar rats (200-240 g) were equally segregated into four groups. Groups I and II were treated with vehicle (0.3 ml/100 g) and groups III and IV received butin 25 and 50 mg/kg for 15 days. Daily 1 h post above oral treatments, 3 ml/kg of normal saline was injected (i.p.) to group I animals and 10 mg/kg of 3-NP was injected (i.p.) to II and IV groups for 15 days. During the experimental schedule, behavioral tests were conducted for animals. On day 15, after behavioral parameters, animals were sacrificed and brains were removed for biochemical tests. Systemic administration of 3-NP induced neurobehavioral deficits which resulted in reduced spontaneous locomotor activity, motor incoordination, learning ability, and memory in the animals. Moreover, 3-NP depleted endogenous antioxidants (GSH, catalase, and SOD), mitochondrial complexes activities (I, II, IV, and MTT assay), elevated LDH, MDA, nitrite, and AchE. Administration of butin significantly improved neurobehavioral impairments, nitrative and oxidative stress, activities of mitochondrial enzyme complex, and reduced AchE levels in rat brain.
Identifiants
pubmed: 34982357
doi: 10.1007/s12640-021-00462-7
pii: 10.1007/s12640-021-00462-7
doi:
Substances chimiques
Benzopyrans
0
Neuroprotective Agents
0
Nitro Compounds
0
Propionates
0
butin
492-14-8
3-nitropropionic acid
QY4L0FOX0D
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
66-77Subventions
Organisme : Al Jouf University
ID : DSR-2021-01-0317
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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