Y chromosome is moving out of sex determination shadow.
Cancer
Diseases
Germ cell tumors
Hepatocellular carcinoma
Inflammation
Male infertility
Neurodegenerative disorders
Prostate cancer
Sex differences
Y chromosome
Journal
Cell & bioscience
ISSN: 2045-3701
Titre abrégé: Cell Biosci
Pays: England
ID NLM: 101561195
Informations de publication
Date de publication:
04 Jan 2022
04 Jan 2022
Historique:
received:
01
09
2021
accepted:
21
12
2021
entrez:
5
1
2022
pubmed:
6
1
2022
medline:
6
1
2022
Statut:
epublish
Résumé
Although sex hormones play a key role in sex differences in susceptibility, severity, outcomes, and response to therapy of different diseases, sex chromosomes are also increasingly recognized as an important factor. Studies demonstrated that the Y chromosome is not a 'genetic wasteland' and can be a useful genetic marker for interpreting various male-specific physiological and pathophysiological characteristics. Y chromosome harbors male‑specific genes, which either solely or in cooperation with their X-counterpart, and independent or in conjunction with sex hormones have a considerable impact on basic physiology and disease mechanisms in most or all tissues development. Furthermore, loss of Y chromosome and/or aberrant expression of Y chromosome genes cause sex differences in disease mechanisms. With the launch of the human proteome project (HPP), the association of Y chromosome proteins with pathological conditions has been increasingly explored. In this review, the involvement of Y chromosome genes in male-specific diseases such as prostate cancer and the cases that are more prevalent in men, such as cardiovascular disease, neurological disease, and cancers, has been highlighted. Understanding the molecular mechanisms underlying Y chromosome-related diseases can have a significant impact on the prevention, diagnosis, and treatment of diseases.
Identifiants
pubmed: 34983649
doi: 10.1186/s13578-021-00741-y
pii: 10.1186/s13578-021-00741-y
pmc: PMC8724748
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
4Informations de copyright
© 2021. The Author(s).
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