Facilitation of colonic T cell immune responses is associated with an exacerbation of dextran sodium sulfate-induced colitis in mice lacking microsomal prostaglandin E synthase-1.
Colitis
Cyclooxygenase
Cytokine
Immunity
Inflammatory bowel disease
Prostaglandin E synthase
Prostaglandin E2
Th17 and Th1 response
Journal
Inflammation and regeneration
ISSN: 1880-9693
Titre abrégé: Inflamm Regen
Pays: England
ID NLM: 101479577
Informations de publication
Date de publication:
04 Jan 2022
04 Jan 2022
Historique:
received:
27
08
2021
accepted:
07
12
2021
entrez:
5
1
2022
pubmed:
6
1
2022
medline:
6
1
2022
Statut:
epublish
Résumé
Microsomal prostaglandin E synthase-1 (mPGES-1) is a key enzyme that acts downstream of cyclooxygenase and plays a major role in inflammation by converting prostaglandin (PG) H Colitis was induced in mice lacking mPGES-1 (mPGES-1 After administration of DSS, mPGES-1 These results demonstrate that mPGES-1 is the main enzyme responsible for colonic PGE
Sections du résumé
BACKGROUND
BACKGROUND
Microsomal prostaglandin E synthase-1 (mPGES-1) is a key enzyme that acts downstream of cyclooxygenase and plays a major role in inflammation by converting prostaglandin (PG) H
METHODS
METHODS
Colitis was induced in mice lacking mPGES-1 (mPGES-1
RESULTS
RESULTS
After administration of DSS, mPGES-1
CONCLUSIONS
CONCLUSIONS
These results demonstrate that mPGES-1 is the main enzyme responsible for colonic PGE
Identifiants
pubmed: 34983695
doi: 10.1186/s41232-021-00188-1
pii: 10.1186/s41232-021-00188-1
pmc: PMC8725565
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1Subventions
Organisme : Kitasato University Graduate School of Medical Sciences
ID : Integrative Research Program 2017-2018
Organisme : Kitasato University Graduate School of Medical Sciences
ID : Student Research Program 2017-2018
Organisme : the Regenerative Medicine and Cell Design Research Facility
ID : Research Program 2018
Organisme : Kitasato University School of Allied Health Sciences
ID : Research Project 2015-1033, 2016-1011, 2017-1019
Organisme : Japan Society for the Promotion of Science
ID : Grant Number 21K06603
Informations de copyright
© 2022. The Author(s).
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