PPARα and PPARγ activation is associated with pleural mesothelioma invasion but therapeutic inhibition is ineffective.
Biological sciences
Metabolomics
Transcriptomics
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
21 Jan 2022
21 Jan 2022
Historique:
received:
23
07
2021
revised:
16
10
2021
accepted:
01
12
2021
entrez:
5
1
2022
pubmed:
6
1
2022
medline:
6
1
2022
Statut:
epublish
Résumé
Mesothelioma is a cancer that typically originates in the pleura of the lungs. It rapidly invades the surrounding tissues, causing pain and shortness of breath. We compared cell lines injected either subcutaneously or intrapleurally and found that only the latter resulted in invasive and rapid growth. Pleural tumors displayed a transcriptional signature consistent with increased activity of nuclear receptors PPARα and PPARγ and with an increased abundance of endogenous PPAR-activating ligands. We found that chemical probe GW6471 is a potent, dual PPARα/γ antagonist with anti-invasive and anti-proliferative activity
Identifiants
pubmed: 34984327
doi: 10.1016/j.isci.2021.103571
pii: S2589-0042(21)01541-8
pmc: PMC8692993
doi:
Types de publication
Journal Article
Langues
eng
Pagination
103571Informations de copyright
© 2021 The Authors.
Déclaration de conflit d'intérêts
The authors declare no competing interests.
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