Determinants of COVID-19-related lethality in multiple sclerosis: a meta-regression of observational studies.
COVID-19
Multiple sclerosis
SARS-COV-2
Journal
Journal of neurology
ISSN: 1432-1459
Titre abrégé: J Neurol
Pays: Germany
ID NLM: 0423161
Informations de publication
Date de publication:
May 2022
May 2022
Historique:
received:
18
11
2021
accepted:
24
12
2021
revised:
23
12
2021
pubmed:
6
1
2022
medline:
23
4
2022
entrez:
5
1
2022
Statut:
ppublish
Résumé
To identify risk factors for an increased lethality of COVID-19 in patients with multiple sclerosis (MS). We searched scientific databases to identify cohort studies with the number of deaths in patients with MS. We fitted inverse-variance weighted meta-regressions with random-effects models to identify potential moderators (determinants) of COVID-19-related lethality (outcome). After an independent screening, 18 articles satisfied the eligibility criteria; all data were collected before anti-SARS-COV-2 vaccination was available. Out of 5,634 patients, 111 died, yielding a pooled death rate of 1.97% (95% confidence intervals 1.61-2.33). There was a substantial heterogeneity between the included studies (Q Except for age and comorbidities, risk factors in common with the general population, we identified MS-specific determinants influencing the lethality of COVID-19. Our findings suggest the implementation of a risk mitigation plan for patients with progressive MS and for those treated with anti-CD20 agents.
Identifiants
pubmed: 34984514
doi: 10.1007/s00415-021-10951-6
pii: 10.1007/s00415-021-10951-6
pmc: PMC8726522
doi:
Substances chimiques
Interferon-beta
77238-31-4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2275-2285Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.
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