Skeletal muscle phenotyping of Hippo gene-mutated mice reveals that Lats1 deletion increases the percentage of type I muscle fibers.
Fiber type
Hippo pathway
Lats1
Skeletal muscle
Transgenic mice
Journal
Transgenic research
ISSN: 1573-9368
Titre abrégé: Transgenic Res
Pays: Netherlands
ID NLM: 9209120
Informations de publication
Date de publication:
04 2022
04 2022
Historique:
received:
24
05
2021
accepted:
02
12
2021
pubmed:
6
1
2022
medline:
13
4
2022
entrez:
5
1
2022
Statut:
ppublish
Résumé
The Hippo signal transduction network regulates transcription through Yap/Taz-Tead1-4 in many tissues including skeletal muscle. Whilst transgenic mice have been generated for many Hippo genes, the resultant skeletal muscle phenotypes were not always characterized. Here, we aimed to phenotype the hindlimb muscles of Hippo gene-mutated Lats1
Identifiants
pubmed: 34984591
doi: 10.1007/s11248-021-00293-4
pii: 10.1007/s11248-021-00293-4
pmc: PMC8993742
doi:
Substances chimiques
RNA, Messenger
0
Lats1 protein, mouse
EC 2.7.1.-
Protein Serine-Threonine Kinases
EC 2.7.11.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
227-237Informations de copyright
© 2022. The Author(s).
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