Using adipose-derived mesenchymal stem cells to fight the metabolic complications of obesity: Where do we stand?
ADMSCs
adipose tissue
metabolic syndrome
obesity
Journal
Obesity reviews : an official journal of the International Association for the Study of Obesity
ISSN: 1467-789X
Titre abrégé: Obes Rev
Pays: England
ID NLM: 100897395
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
revised:
07
12
2021
received:
11
10
2021
accepted:
07
12
2021
pubmed:
6
1
2022
medline:
13
4
2022
entrez:
5
1
2022
Statut:
ppublish
Résumé
Obesity is a critical risk factor for the development of metabolic diseases, and its prevalence is increasing worldwide. Stem cell-based therapies have become a promising tool for therapeutic intervention. Among them are adipose-derived mesenchymal stem cells (ADMSCs), secreting numerous bioactive molecules, like growth factors, cytokines, and chemokines. Their unique features, including immunosuppressive and immunomodulatory properties, make them an ideal candidates for clinical applications. Numerous experimental studies have shown that ADMSCs can improve pancreatic islet cell viability and function, ameliorate hyperglycemia, improve insulin sensitivity, restore liver function, counteract dyslipidemia, lower pro-inflammatory cytokines, and reduce oxidative stress in the animal models. These results prompted scientists to use ADMSCs clinically. However, up to date, there have been few clinical studies or ongoing trails using ADMSCs to treat metabolic disorders such as type 2 diabetes mellitus (T2DM) or liver cirrhosis. Most human studies have implemented autologous ADMSCs with minimal risk of cellular rejection. Because the functionality of ADMSCs is significantly reduced in subjects with obesity and/or metabolic syndrome, their efficacy is questioned. ADMSCs transplantation may offer a potential therapeutic approach for the treatment of metabolic complications of obesity, but randomized controlled trials are required to establish their safety and efficacy in humans prior to routine clinical use.
Identifiants
pubmed: 34985174
doi: 10.1111/obr.13413
pmc: PMC9285813
doi:
Substances chimiques
Cytokines
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13413Informations de copyright
© 2022 The Authors. Obesity Reviews published by John Wiley & Sons Ltd on behalf of World Obesity Federation.
Références
Biochem Biophys Res Commun. 2017 Jan 29;483(1):435-441
pubmed: 28013047
Nutrients. 2021 Jul 19;13(7):
pubmed: 34371968
Stem Cells Transl Med. 2016 Sep;5(9):1162-70
pubmed: 27381991
World J Diabetes. 2019 May 15;10(5):280-290
pubmed: 31139315
Nature. 2006 Dec 14;444(7121):860-7
pubmed: 17167474
J Am Coll Cardiol. 2009 Dec 8;54(24):2277-86
pubmed: 19958962
Methods Mol Biol. 2012;826:217-23
pubmed: 22167651
Endocrine. 2014 Apr;45(3):344-53
pubmed: 24287794
Am J Physiol Cell Physiol. 2008 Mar;294(3):C675-82
pubmed: 18234850
Mol Med Rep. 2015 Sep;12(3):3725-3733
pubmed: 26018346
Cardiovasc Res. 2019 May 1;115(6):1041-1051
pubmed: 30388208
Atherosclerosis. 2014 May;234(1):218-23
pubmed: 24681911
Front Immunol. 2021 Jun 24;12:650768
pubmed: 34248937
Stem Cells. 2009 Aug;27(8):1999-2008
pubmed: 19544420
Wound Repair Regen. 2006 May-Jun;14(3):325-35
pubmed: 16808812
Diabetologia. 2014 Jan;57(1):167-76
pubmed: 24100782
Antioxid Redox Signal. 2019 Aug 20;31(6):487-501
pubmed: 30234364
Liver Int. 2017 Jan;37 Suppl 1:85-89
pubmed: 28052629
Indian J Endocrinol Metab. 2012 Mar;16 Suppl 1:S65-9
pubmed: 22701849
Sci Rep. 2019 Dec 30;9(1):20304
pubmed: 31889120
Cell Mol Life Sci. 2018 Nov;75(22):4079-4091
pubmed: 29946805
Metabolism. 2005 Mar;54(3):281-6
pubmed: 15736103
Cell Metab. 2008 May;7(5):410-20
pubmed: 18460332
J Pathol. 2013 Jan;229(2):176-85
pubmed: 23096265
Stem Cells Dev. 2020 Apr 15;29(8):488-497
pubmed: 32075539
Cell Transplant. 2013;22(6):1053-60
pubmed: 23031216
Obes Rev. 2014 Jun;15(6):504-15
pubmed: 24661566
Crit Care Med. 2012 Apr;40(4):1279-90
pubmed: 22336724
J Korean Surg Soc. 2011 Sep;81(3):176-86
pubmed: 22066119
J Biochem Mol Toxicol. 2017 Aug;31(8):
pubmed: 28422374
Cytotherapy. 2014 Mar;16(3):309-18
pubmed: 24239106
Eur J Gastroenterol Hepatol. 2009 Oct;21(10):1199-205
pubmed: 19455046
Endocr J. 2015;62(4):339-52
pubmed: 25739585
Exp Biol Med (Maywood). 2019 May;244(7):565-578
pubmed: 30935234
Science. 1998 Nov 6;282(5391):1145-7
pubmed: 9804556
Cytometry A. 2014 Jan;85(1):43-77
pubmed: 24700575
Immunol Lett. 2009 Sep 22;126(1-2):37-42
pubmed: 19647021
Arch Intern Med. 2008 Aug 11;168(15):1617-24
pubmed: 18695075
Nutr Rev. 2012 Jan;70(1):3-21
pubmed: 22221213
Tissue Eng. 2001 Apr;7(2):211-28
pubmed: 11304456
Am J Physiol Regul Integr Comp Physiol. 2006 Oct;291(4):R880-4
pubmed: 16728464
Am J Physiol Heart Circ Physiol. 2004 Dec;287(6):H2670-6
pubmed: 15284059
Nature. 1981 Jul 9;292(5819):154-6
pubmed: 7242681
Am J Physiol Endocrinol Metab. 2010 Sep;299(3):E506-15
pubmed: 20570822
Sci Rep. 2011;1:81
pubmed: 22355600
J Cell Biochem. 2017 Aug;118(8):2037-2043
pubmed: 27791278
Eat Weight Disord. 2018 Apr;23(2):149-157
pubmed: 29397563
Biomed Pharmacother. 2016 Dec;84:1662-1667
pubmed: 27842906
Cytokine Growth Factor Rev. 2009 Oct-Dec;20(5-6):419-27
pubmed: 19926330
Mol Ther. 2018 Aug 1;26(8):1921-1930
pubmed: 30005867
Cytotherapy. 2016 Oct;18(10):1297-311
pubmed: 27637760
Cytotherapy. 2013 Jun;15(6):641-8
pubmed: 23570660
Hum Reprod. 2016 May;31(5):1075-86
pubmed: 26965432
Regen Ther. 2020 May 15;14:252-261
pubmed: 32455155
Eur J Clin Nutr. 2022 Feb;76(2):184-195
pubmed: 34040197
Circ Res. 2007 May 11;100(9):1249-60
pubmed: 17495232
Nutrients. 2021 Jun 30;13(7):
pubmed: 34208833
Curr Probl Cardiol. 2006 Jul;31(7):445-86
pubmed: 16824902
Obes Rev. 2022 May;23(5):e13413
pubmed: 34985174
Stem Cell Res Ther. 2015 Oct 05;6:193
pubmed: 26438426
Stem Cells Int. 2014;2014:720753
pubmed: 25548574
J Endocrinol. 2013 Aug 28;218(3):R25-36
pubmed: 23833274
Stem Cells Int. 2018 Jan 28;2018:7318513
pubmed: 29535779
Cell Stem Cell. 2012 Jun 14;10(6):709-716
pubmed: 22704511
Curr Stem Cell Res Ther. 2018;13(6):466-475
pubmed: 29766824
Gut. 2008 Feb;57(2):223-31
pubmed: 17639088
Int J Mol Sci. 2021 Jul 16;22(14):
pubmed: 34299261
Obes Rev. 2014 Oct;15(10):781-90
pubmed: 25040597
Ann Surg. 2016 Mar;263(3):546-56
pubmed: 25775061
Obes Rev. 2012 Dec;13 Suppl 2:1-5
pubmed: 23107254
Life Sci. 2018 Dec 1;214:62-69
pubmed: 30381247
Gut. 2009 Apr;58(4):570-81
pubmed: 19022918
J Gastroenterol Hepatol. 2009 Jan;24(1):70-7
pubmed: 18624899
Diabetes Metab Syndr Obes. 2021 Jun 21;14:2807-2827
pubmed: 34188505
Circ Res. 2021 Apr 2;128(7):951-968
pubmed: 33793327
Metabolism. 2019 Mar;92:51-60
pubmed: 30458177
Int J Obes (Lond). 2019 Oct;43(10):2107-2118
pubmed: 31462691
Gut. 2013 Aug;62(8):1131-41
pubmed: 22637701
Int J Mol Med. 2016 Jan;37(1):115-25
pubmed: 26719857
Biochem Biophys Res Commun. 2014 Jan 10;443(2):775-81
pubmed: 24148246
Int J Obes (Lond). 2011 Jul;35(7):971-81
pubmed: 20975726
Cytotherapy. 2006;8(4):315-7
pubmed: 16923606
Circulation. 2004 Mar 16;109(10):1292-8
pubmed: 14993122
Stem Cells. 2009 Aug;27(8):1941-53
pubmed: 19544426
J Hepatol. 2011 Nov;55(5):1112-20
pubmed: 21356258
PLoS One. 2011;6(6):e20615
pubmed: 21687731
Obes Rev. 2010 Jan;11(1):11-8
pubmed: 19656312
Diabetes. 2015 Mar;64(3):926-36
pubmed: 25277392
J Cell Biol. 2015 Mar 2;208(5):501-12
pubmed: 25733711
Stem Cells. 2006 Oct;24(10):2292-8
pubmed: 16778155
PLoS One. 2020 Nov 9;15(11):e0241993
pubmed: 33166340
Science. 2005 Jan 21;307(5708):380-4
pubmed: 15662003
Mol Ther. 2012 Jan;20(1):14-20
pubmed: 22008910
Sci Rep. 2021 Mar 18;11(1):6291
pubmed: 33737713
Stem Cell Res Ther. 2019 Nov 20;10(1):333
pubmed: 31747961
Stem Cell Res Ther. 2019 Jul 8;10(1):199
pubmed: 31287024
Stem Cells. 2010 Jun;28(6):1099-106
pubmed: 20506226
Endocrine. 2006 Feb;29(1):81-90
pubmed: 16622295
PLoS One. 2014 Dec 01;9(12):e113936
pubmed: 25436769
Reprod Biol Endocrinol. 2015 Sep 23;13:108
pubmed: 26394676
Cells. 2021 Jun 16;10(6):
pubmed: 34208471
Cell Stem Cell. 2012 Dec 7;11(6):812-24
pubmed: 23168163
J Gastroenterol Hepatol. 2019 Aug;34(8):1432-1440
pubmed: 30828861
Genomics. 1991 Dec;11(4):1054-62
pubmed: 1686014
Hepatology. 2013 Sep;58(3):1133-42
pubmed: 23686813
Stem Cells. 2008 Oct;26(10):2705-12
pubmed: 18535155
Transl Res. 2017 Apr;182:61-74.e8
pubmed: 27908750
Int J Obes (Lond). 2010 Dec;34 Suppl 2:S18-23
pubmed: 21151142
Lancet. 2016 Sep 24;388(10051):1281-90
pubmed: 27477896
Cytotherapy. 2013 May;15(5):557-70
pubmed: 23388582
Int J Dev Biol. 2010;54(4):699-705
pubmed: 19757377
BMC Genomics. 2013 Sep 16;14:625
pubmed: 24040759
Arterioscler Thromb Vasc Biol. 2009 Nov;29(11):1723-9
pubmed: 19628786
Nature. 2008 Jun 5;453(7196):783-7
pubmed: 18454136
Arterioscler Thromb Vasc Biol. 2000 Jun;20(6):1595-9
pubmed: 10845877
Nutrients. 2021 Jun 19;13(6):
pubmed: 34205356
Vasc Health Risk Manag. 2008;4(5):1001-9
pubmed: 19183748
Stem Cells Int. 2017;2017:1653254
pubmed: 28757877
PLoS Comput Biol. 2009 Mar;5(3):e1000324
pubmed: 19325873
PLoS One. 2010 Apr 26;5(4):e10088
pubmed: 20436665
Diabetologia. 2003 Jan;46(1):3-19
pubmed: 12637977
Stem Cell Res Ther. 2015 Oct 31;6:208
pubmed: 26519255
Cells. 2019 May 15;8(5):
pubmed: 31096722
Acta Diabetol. 2015 Oct;52(5):855-63
pubmed: 25690647
Biotechnol Lett. 2011 Jun;33(6):1257-64
pubmed: 21287233
Int J Mol Sci. 2021 Jun 27;22(13):
pubmed: 34199035
Mol Ther. 2012 Jan;20(1):187-95
pubmed: 21934657
Biochem Biophys Res Commun. 2006 Mar 24;341(4):1135-40
pubmed: 16460677
Eur J Pharmacol. 2020 Aug 15;881:173215
pubmed: 32473166
Sci Rep. 2016 Nov 24;6:37801
pubmed: 27883074
Nat Med. 2018 Jul;24(7):908-922
pubmed: 29967350
Biomolecules. 2021 Jun 22;11(7):
pubmed: 34206204
Stem Cell Res Ther. 2017 Dec 19;8(1):286
pubmed: 29258603
Postepy Hig Med Dosw (Online). 2017 Jun 8;71(0):466-484
pubmed: 28665277
Front Endocrinol (Lausanne). 2016 Apr 13;7:30
pubmed: 27148161
Stem Cell Res Ther. 2017 Dec 6;8(1):275
pubmed: 29208029
Biochem Biophys Res Commun. 2015 Jan 24;456(4):860-5
pubmed: 25490388
Int J Mol Med. 2014 Sep;34(3):695-704
pubmed: 24970492
Kidney Int Suppl (2011). 2011 Sep;1(3):103-106
pubmed: 25018910
Stem Cell Res Ther. 2019 Sep 2;10(1):280
pubmed: 31477174
Biomed Pharmacother. 2021 May;137:111315
pubmed: 33561645
Regen Ther. 2017 Mar 09;6:52-64
pubmed: 30271839
Int J Mol Sci. 2014 Apr 29;15(5):7352-79
pubmed: 24786095
Tissue Eng Part A. 2015 May;21(9-10):1621-32
pubmed: 25668104
Metabolism. 2001 Dec;50(12):1499-504
pubmed: 11735101
Exp Biol Med (Maywood). 2017 May;242(10):1079-1085
pubmed: 27909015
Stem Cells Int. 2019 Nov 5;2019:7921760
pubmed: 31781246
Chronic Dis Transl Med. 2017 May 25;3(2):89-94
pubmed: 29063061