A Cholesterol Dimer Stabilizes the Inactivated State of an Inward-Rectifier Potassium Channel.
Cholesterol
Inward-Rectifier K+ Channels
Membrane Proteins
NMR Structure
Solid-State NMR
Journal
Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543
Informations de publication
Date de publication:
21 03 2022
21 03 2022
Historique:
received:
08
09
2021
pubmed:
6
1
2022
medline:
12
4
2022
entrez:
5
1
2022
Statut:
ppublish
Résumé
Cholesterol oligomers reside in multiple membrane protein X-ray crystal structures. Yet, there is no direct link between these oligomers and a biological function. Here we present the structural and functional details of a cholesterol dimer that stabilizes the inactivated state of an inward-rectifier potassium channel KirBac1.1. K
Identifiants
pubmed: 34985791
doi: 10.1002/anie.202112232
pmc: PMC8957755
mid: NIHMS1773581
doi:
Substances chimiques
Potassium Channels, Inwardly Rectifying
0
Cholesterol
97C5T2UQ7J
Potassium
RWP5GA015D
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202112232Subventions
Organisme : NIGMS NIH HHS
ID : P41 GM111135
Pays : United States
Organisme : NIGMS NIH HHS
ID : P41 GM136463
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM124979
Pays : United States
Informations de copyright
© 2022 Wiley-VCH GmbH.
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