Calcium-dependent ESCRT recruitment and lysosome exocytosis maintain epithelial integrity during Candida albicans invasion.
Animals
Calcium
/ metabolism
Candida albicans
/ metabolism
Candidiasis
/ pathology
Cell Line
Cell Membrane
/ physiology
Endosomal Sorting Complexes Required for Transport
/ metabolism
Epithelial Cells
/ metabolism
Exocytosis
/ physiology
Fungal Proteins
/ genetics
Host-Pathogen Interactions
Humans
Hyphae
/ growth & development
Lysosomes
/ metabolism
Mice
Mucous Membrane
/ cytology
Phosphotransferases (Alcohol Group Acceptor)
/ metabolism
RAW 264.7 Cells
ALG-2
Candida albicans
ESCRT
calcium
candidalysin
epithelia
lysosome
membrane damage
plasma membrane
repair
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
04 01 2022
04 01 2022
Historique:
received:
24
06
2021
revised:
21
07
2021
accepted:
07
12
2021
entrez:
5
1
2022
pubmed:
6
1
2022
medline:
17
2
2022
Statut:
ppublish
Résumé
Candida albicans is both a commensal and an opportunistic fungal pathogen. Invading hyphae of C. albicans secrete candidalysin, a pore-forming peptide toxin. To prevent cell death, epithelial cells must protect themselves from direct damage induced by candidalysin and by the mechanical forces exerted by expanding hyphae. We identify two key Ca
Identifiants
pubmed: 34986345
pii: S2211-1247(21)01687-9
doi: 10.1016/j.celrep.2021.110187
pmc: PMC8755444
pii:
doi:
Substances chimiques
ECE1 protein, Candida albicans
0
Endosomal Sorting Complexes Required for Transport
0
Fungal Proteins
0
Phosphotransferases (Alcohol Group Acceptor)
EC 2.7.1.-
phosphatidylinositol 4,5-biphosphate kinase
EC 2.7.1.-
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
110187Subventions
Organisme : NIDCR NIH HHS
ID : R01 DE022550
Pays : United States
Organisme : NIDCR NIH HHS
ID : R37 DE022550
Pays : United States
Organisme : CIHR
ID : FDN-143202
Pays : Canada
Organisme : Wellcome Trust
ID : 214229_Z_18_Z
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.
Références
J Exp Med. 2009 Feb 16;206(2):299-311
pubmed: 19204111
Cell Microbiol. 2021 Oct;23(10):e13371
pubmed: 34085369
Front Immunol. 2019 Feb 27;10:330
pubmed: 30873177
Curr Opin Microbiol. 2019 Dec;52:100-109
pubmed: 31288097
Sci Immunol. 2020 Jun 5;5(48):
pubmed: 32503875
Science. 2014 Feb 28;343(6174):1247136
pubmed: 24482116
J Cell Biol. 2000 Dec 25;151(7):1353-68
pubmed: 11134066
Science. 2011 Mar 25;331(6024):1616-20
pubmed: 21310966
Eur J Immunol. 2018 Mar;48(3):464-470
pubmed: 29150834
J Leukoc Biol. 2000 Nov;68(5):627-32
pubmed: 11073100
PLoS Pathog. 2021 Sep 10;17(9):e1009884
pubmed: 34506615
J Natl Cancer Inst. 1985 Oct;75(4):621-35
pubmed: 2413234
Nature. 2016 Apr 7;532(7597):64-8
pubmed: 27027296
Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12211-6
pubmed: 25099357
Protoplasma. 2013 Oct;250(5):1131-7
pubmed: 23456458
Cell Microbiol. 2010 Feb;12(2):248-71
pubmed: 19863559
J Cell Biol. 2000 Mar 20;148(6):1141-49
pubmed: 10725327
J Cell Sci. 2011 Jul 15;124(Pt 14):2414-23
pubmed: 21693578
Cell Host Microbe. 2010 Sep 16;8(3):225-35
pubmed: 20833374
Biochim Biophys Acta. 2003 Sep 30;1606(1-3):137-46
pubmed: 14507434
Cell Host Microbe. 2019 Mar 13;25(3):432-443.e6
pubmed: 30870623
mBio. 2018 Sep 11;9(5):
pubmed: 30206168
J Infect Dis. 2019 Sep 26;220(9):1477-1488
pubmed: 31401652
Clin Microbiol Rev. 2007 Jan;20(1):133-63
pubmed: 17223626
Nat Commun. 2014 Dec 23;5:5646
pubmed: 25534348
Cell Host Microbe. 2020 Dec 9;28(6):798-812.e6
pubmed: 33022213
Curr Opin Microbiol. 2020 Aug;56:7-15
pubmed: 32604030
Nat Commun. 2019 May 24;10(1):2297
pubmed: 31127085
Virulence. 2013 Feb 15;4(2):119-28
pubmed: 23302789
Cell. 2001 Jul 27;106(2):157-69
pubmed: 11511344
Nature. 2013 Jul 18;499(7458):295-300
pubmed: 23868258
PLoS Pathog. 2013;9(6):e1003446
pubmed: 23825946
Cell Death Differ. 2009 Aug;16(8):1126-34
pubmed: 19325569
Nat Cell Biol. 2001 Jul;3(7):675-8
pubmed: 11433300
Mycoses. 2005 Nov;48(6):365-77
pubmed: 16262871
Biochim Biophys Acta. 2016 Nov;1860(11 Pt A):2498-2509
pubmed: 27481675
Med Mycol. 2007 Jun;45(4):321-46
pubmed: 17510856
Cell Microbiol. 2019 Apr;21(4):e13016
pubmed: 30740852
Mol Pharm. 2012 Sep 4;9(9):2686-97
pubmed: 22873645
Elife. 2018 Mar 19;7:
pubmed: 29553370
Cell Microbiol. 2007 Dec;9(12):2938-54
pubmed: 17645752
J Cell Biol. 2014 Apr 14;205(1):113-26
pubmed: 24711504
Mucosal Immunol. 2017 Sep;10(5):1335-1350
pubmed: 28176789
Eukaryot Cell. 2009 Mar;8(3):373-87
pubmed: 19151328
Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14270-5
pubmed: 21825168
Structure. 2001 Apr 4;9(4):267-75
pubmed: 11525164
mBio. 2018 Jun 5;9(3):
pubmed: 29871918
Microbes Infect. 2007 Apr;9(5):615-22
pubmed: 17383212
Virulence. 2015;6(4):338-46
pubmed: 25714110
J Neurosci Methods. 1999 Oct 30;93(1):37-48
pubmed: 10598863
Mol Biol Cell. 2012 Jan;23(1):176-87
pubmed: 22072788
Cell Microbiol. 2021 Oct;23(10):e13378
pubmed: 34245079
Mycoses. 2001 Nov;44(9-10):361-7
pubmed: 11766099