The Human Proteoform Atlas: a FAIR community resource for experimentally derived proteoforms.
Alternative Splicing
Amino Acid Sequence
Atlases as Topic
Databases, Protein
Gene Ontology
Humans
Models, Molecular
Molecular Sequence Annotation
Polymorphism, Single Nucleotide
Protein Conformation
Protein Isoforms
/ chemistry
Protein Processing, Post-Translational
Proteome
/ chemistry
Proto-Oncogene Proteins p21(ras)
/ chemistry
RNA, Messenger
/ genetics
User-Computer Interface
Journal
Nucleic acids research
ISSN: 1362-4962
Titre abrégé: Nucleic Acids Res
Pays: England
ID NLM: 0411011
Informations de publication
Date de publication:
07 01 2022
07 01 2022
Historique:
accepted:
14
11
2021
revised:
06
10
2021
received:
15
08
2021
entrez:
6
1
2022
pubmed:
7
1
2022
medline:
24
2
2022
Statut:
ppublish
Résumé
The Human Proteoform Atlas (HPfA) is a web-based repository of experimentally verified human proteoforms on-line at http://human-proteoform-atlas.org and is a direct descendant of the Consortium of Top-Down Proteomics' (CTDP) Proteoform Atlas. Proteoforms are the specific forms of protein molecules expressed by our cells and include the unique combination of post-translational modifications (PTMs), alternative splicing and other sources of variation deriving from a specific gene. The HPfA uses a FAIR system to assign persistent identifiers to proteoforms which allows for redundancy calling and tracking from prior and future studies in the growing community of proteoform biology and measurement. The HPfA is organized around open ontologies and enables flexible classification of proteoforms. To achieve this, a public registry of experimentally verified proteoforms was also created. Submission of new proteoforms can be processed through email vianrtdphelp@northwestern.edu, and future iterations of these proteoform atlases will help to organize and assign function to proteoforms, their PTMs and their complexes in the years ahead.
Identifiants
pubmed: 34986596
pii: 6431814
doi: 10.1093/nar/gkab1086
pmc: PMC8728143
doi:
Substances chimiques
KRAS protein, human
0
Protein Isoforms
0
Proteome
0
RNA, Messenger
0
Proto-Oncogene Proteins p21(ras)
EC 3.6.5.2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
D526-D533Subventions
Organisme : NIGMS NIH HHS
ID : P41 GM108569
Pays : United States
Organisme : NLM NIH HHS
ID : R21 LM013097
Pays : United States
Informations de copyright
© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.
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