Novel Trypanocidal Inhibitors that Block Glycosome Biogenesis by Targeting PEX3-PEX19 Interaction.
PEX3-PEX19 inhibitor
PPI inhibitors
alphascreen
glycosome biogenesis
neglected tropical diseases
protein–protein interaction
small-molecule inhibitor screen
trypanosoma
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2021
2021
Historique:
received:
06
07
2021
accepted:
15
11
2021
entrez:
6
1
2022
pubmed:
7
1
2022
medline:
7
1
2022
Statut:
epublish
Résumé
Human pathogenic trypanosomatid parasites harbor a unique form of peroxisomes termed glycosomes that are essential for parasite viability. We and others previously identified and characterized the essential
Identifiants
pubmed: 34988071
doi: 10.3389/fcell.2021.737159
pii: 737159
pmc: PMC8721105
doi:
Types de publication
Journal Article
Langues
eng
Pagination
737159Informations de copyright
Copyright © 2021 Li, Gaussmann, Tippler, Ott, Popowicz, Schliebs, Sattler, Erdmann and Kalel.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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