Subjective arousal and perceived control clarify heterogeneity in inflammatory and affective outcomes.
Anhedonia
Anxiety
C-Reactive protein
Depression
Interleukin-6
K-means clustering
Perceived control
Psychopathology
Stress
Subjective arousal
Journal
Brain, behavior, & immunity - health
ISSN: 2666-3546
Titre abrégé: Brain Behav Immun Health
Pays: United States
ID NLM: 101759062
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
23
08
2021
revised:
27
08
2021
accepted:
28
08
2021
entrez:
6
1
2022
pubmed:
7
1
2022
medline:
7
1
2022
Statut:
epublish
Résumé
Only a portion of individuals experiencing chronic stress and associated increases in inflammation go on to develop pathological elevations in mood and anxiety symptoms. Some prevailing models suggest that the outcomes of chronic stress may largely depend on individual differences in perceived control. In the current study, we used this theoretical framework to disambiguate the influence of autonomic arousal and perceived control on inflammatory and psychological outcomes in a large sample of adults from the Midlife in the United States dataset (wave 2; MIDUS-2) (Final N = 1030), and further replicated our approach in a second (MIDUS-Refresher) cohort (Final N = 728). Using k-means clustering we created subgroups systematically differing in subjective arousal (high/low) and perceived control (low/high) and compared these subgroups on inflammatory markers and psychological outcomes. Overall results showed that individuals in the high subjective arousal subgroups had higher levels of IL-6, CRP, and FIB, independent of level of CNTL. However, distinctive, and pathological psychological symptom patterns became more apparent when individuals were characterized by both subjective arousal and perceived control. These findings suggest that subtyping individuals based on subjective arousal and perceived control can help us disentangle pathological versus adaptive mental health outcomes in those with co-occurring inflammation and may help identify those vulnerable to psychopathology in the context of physical or psychological stressor exposure.
Identifiants
pubmed: 34988494
doi: 10.1016/j.bbih.2021.100341
pii: S2666-3546(21)00144-7
pmc: PMC8710414
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100341Déclaration de conflit d'intérêts
None.
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