Red blood cell fatty acids and age-related macular degeneration in postmenopausal women.
Age-related macular degeneration
Cohort
Diet
Epidemiology
Fatty acids
Post-menopausal women
Retinal disease
Journal
European journal of nutrition
ISSN: 1436-6215
Titre abrégé: Eur J Nutr
Pays: Germany
ID NLM: 100888704
Informations de publication
Date de publication:
Apr 2022
Apr 2022
Historique:
received:
05
08
2021
accepted:
16
11
2021
pubmed:
7
1
2022
medline:
17
3
2022
entrez:
6
1
2022
Statut:
ppublish
Résumé
To evaluate the relationship between red blood cell (RBC) polyunsaturated fatty acid (PUFA) levels, and dietary PUFA and fish intake, with prevalent and incident age-related macular degeneration (AMD) in a US cohort of postmenopausal women. This analysis included 1456 postmenopausal women from the Women's Health Initiative (WHI) Clinical Trials. RBC PUFAs were measured from fasting serum samples collected at WHI baseline. Dietary PUFAs and fish intake were assessed via food frequency questionnaires at baseline. There were 240 women who had prevalent AMD and 138 who self-reported AMD development over 9.5 years. Adjusted odds ratios and 95% confidence intervals were estimated for prevalent AMD by RBC PUFA levels, dietary PUFA intake, and frequency of fish consumption. Adjusted hazard ratios and 95% confidence intervals were estimated for incident AMD. A p-for-trend was estimated for continuous measures of dietary PUFA and fish intake. No significant association was found between prevalent or incident AMD and RBC docosahexaenoic acid (DHA) + eicosapentaenoic acid (EPA), EPA, DHA, alpha-linolenic acid (ALA), linoleic acid (LA), or arachidonic acid (AA). A positive association was found between dietary intake of AA and odds of prevalent AMD (p-for-trend for continuous AA intake = 0.02) and between intake of LA/ALA and incident AMD (p-for-trend for continuous ratio of LA/ALA intake = 0.03). No statistically significant associations were found between AMD and dietary intake of PUFAs or fish. RBC PUFAs were not associated with AMD in this cohort. Overall, dietary analyses of PUFAs supported this, excepting dietary AA intake and intake of LA in proportion to ALA of which there were trends of increased risk.
Identifiants
pubmed: 34988653
doi: 10.1007/s00394-021-02746-2
pii: 10.1007/s00394-021-02746-2
doi:
Substances chimiques
Fatty Acids
0
Fatty Acids, Omega-3
0
Eicosapentaenoic Acid
AAN7QOV9EA
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1585-1594Subventions
Organisme : NHLBI NIH HHS
ID : NIH contract HHSN268200900036C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201100046C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201100001C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201100002C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201100003C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201100004C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN271201100004C.
Pays : United States
Organisme : NHLBI NIH HHS
ID : NIH contract HHSN268200900036C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201100046C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201100001C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201100002C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201100003C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201100004C
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN271201100004C.
Pays : United States
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.
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