Greasing the inflammatory pathogenesis of viral pneumonias in diabetes.
SARS-CoV2
adipocytes
diabetes
immunometabolism
obesity
Journal
Obesity reviews : an official journal of the International Association for the Study of Obesity
ISSN: 1467-789X
Titre abrégé: Obes Rev
Pays: England
ID NLM: 100897395
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
revised:
01
12
2021
received:
16
09
2021
accepted:
02
12
2021
pubmed:
7
1
2022
medline:
13
4
2022
entrez:
6
1
2022
Statut:
ppublish
Résumé
Type 2 diabetes (T2D) and obesity are independent risk factors for increased morbidity and mortality associated with influenza and SARS-CoV-2 infection. Skewed cellular metabolism shapes immune cell inflammatory responsiveness and function in obesity, T2D, and infection. However, altered immune cell responsiveness and levels of systemic proinflammatory mediators, partly independent of peripheral immune cell contribution, are linked with SARS-CoV-2-associated disease severity. Despite such knowledge, the role of tissue parenchymal cell-driven inflammatory responses, and specifically those dominantly modified in obesity (e.g., adipocytes), in influenza and SARS-CoV-2 infection pathogenesis remain poorly defined. Whether obesity-dependent skewing of adipocyte cellular metabolism uncovers inflammatory clades and promotes the existence of a 'pathogenic-inflammatory' adipocyte phenotype that amplifies SARS-CoV-2 infection diseases severity in individuals with obesity and individuals with obesity and T2D has not been examined. Here, using the knowledge gained from studies of immune cell responses in obesity, T2D, and infection, we highlight the key knowledge gaps underlying adipocyte cellular functions that may sculpt and grease pathogenic processes associated with influenza and SARS-CoV-2 disease severity in diabetes.
Identifiants
pubmed: 34989117
doi: 10.1111/obr.13415
pmc: PMC9771603
mid: NIHMS1855283
doi:
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13415Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK078392
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK099222
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL157260
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM063483
Pays : United States
Informations de copyright
© 2022 World Obesity Federation.
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