microRNAs and long non-coding RNAs as biomarkers for polycystic ovary syndrome.
long non-coding RNA
microRNAs
ovary
polycystic ovary syndrome
Journal
Journal of cellular and molecular medicine
ISSN: 1582-4934
Titre abrégé: J Cell Mol Med
Pays: England
ID NLM: 101083777
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
revised:
05
11
2021
received:
28
08
2021
accepted:
29
11
2021
pubmed:
7
1
2022
medline:
1
4
2022
entrez:
6
1
2022
Statut:
ppublish
Résumé
Polycystic ovary syndrome (PCOS) is known as the most common metabolic/endocrine disorder among women of reproductive age. Its complicated causality assessment and diagnostic emphasized the role of non-coding regulatory RNAs as molecular biomarkers in studying, diagnosing and even as therapeutics of PCOS. This review discusses a comparative summary of research into microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) that are molecularly or statistically related to PCOS. We categorize the literature in terms of centering on either miRNAs or lncRNAs and discuss the combinatory studies and promising ideas as well. Additionally, we compare the pros and cons of the prominent research methodologies used for each of the abovementioned research themes and discuss how errors can be stopped from propagation by selecting correct methodologies for future research. Finally, it can be concluded that research into miRNAs and lncRNAs has the potential for identifying functional networks of regulation with multiple mRNAs (and hence, functional proteins). This new understanding may eventually afford clinicians to control the molecular course of the pathogenesis better. With further research, RNA (with statistical significance and present in the blood) may be used as biomarkers for the disease, and more possibilities for RNA therapy agents can be identified.
Identifiants
pubmed: 34989136
doi: 10.1111/jcmm.17139
pmc: PMC8817139
doi:
Substances chimiques
Biomarkers
0
MicroRNAs
0
RNA, Long Noncoding
0
RNA, Messenger
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
654-670Informations de copyright
© 2022 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.
Références
Cell Biosci. 2019 Feb 15;9:19
pubmed: 30815248
J Ovarian Res. 2019 May 7;12(1):39
pubmed: 31064393
Fertil Steril. 2020 Mar;113(3):661-669.e2
pubmed: 32192599
Reprod Biol Endocrinol. 2018 Aug 3;16(1):73
pubmed: 30075721
Gene. 2020 Sep 5;754:144903
pubmed: 32540374
Mol Med Rep. 2019 Jul;20(1):281-291
pubmed: 31115532
Mol Ther Nucleic Acids. 2020 Jun 5;20:205-216
pubmed: 32179451
Reprod Biomed Online. 2020 Oct;41(4):579-583
pubmed: 32819839
Taiwan J Obstet Gynecol. 2020 May;59(3):372-376
pubmed: 32416882
Cell. 2009 Jan 9;136(1):26-36
pubmed: 19135886
Mol Cell Endocrinol. 2019 Aug 20;494:110478
pubmed: 31173821
Nat Rev Endocrinol. 2018 May;14(5):270-284
pubmed: 29569621
Ann Endocrinol (Paris). 2020 Feb;81(1):18-27
pubmed: 32127169
Gynecol Endocrinol. 2018 Sep;34(9):793-797
pubmed: 29637801
Inflamm Bowel Dis. 2021 May 17;27(6):760-770
pubmed: 33438720
Endocrinol Metab (Seoul). 2021 Apr;36(2):296-311
pubmed: 33853290
Endocr J. 2019 Jul 28;66(7):587-595
pubmed: 30982795
J Assist Reprod Genet. 2020 Oct;37(10):2513-2523
pubmed: 32783135
Gynecol Endocrinol. 2018 Aug;34(8):704-708
pubmed: 29385860
Gene. 2018 May 30;657:19-29
pubmed: 29505837
Sci Rep. 2020 Sep 7;10(1):14738
pubmed: 32895427
Aging (Albany NY). 2021 Mar 10;13(6):8481-8496
pubmed: 33714202
Arch Gynecol Obstet. 2021 Mar;303(3):631-643
pubmed: 33439300
Indian J Clin Biochem. 2020 Apr;35(2):169-178
pubmed: 32226248
Gynecol Endocrinol. 2021 Mar;37(3):216-220
pubmed: 33148068
J Ovarian Res. 2020 Dec 12;13(1):145
pubmed: 33308258
Biomed Pharmacother. 2018 Apr;100:250-256
pubmed: 29432996
Med Sci Monit. 2016 Dec 31;22:5240-5248
pubmed: 28039689
Aging (Albany NY). 2020 Jul 10;12(15):15414-15435
pubmed: 32651991
RNA Biol. 2020 Dec;17(12):1798-1810
pubmed: 32559120
Cell Biol Int. 2020 Mar 28;:
pubmed: 32222120
Mol Ther. 2021 Mar 3;29(3):1279-1293
pubmed: 33212300
Reprod Sci. 2018 Mar;25(3):372-383
pubmed: 28673204
Int J Mol Cell Med. 2020 Summer;9(3):198-206
pubmed: 33274182
Reprod Biol Endocrinol. 2018 Oct 15;16(1):96
pubmed: 30322386
EBioMedicine. 2018 Oct;36:526-538
pubmed: 30293818
Reprod Biomed Online. 2018 Nov;37(5):613-623
pubmed: 30224242
Biol Reprod. 2020 Oct 29;103(5):978-985
pubmed: 32720692
Arch Gynecol Obstet. 2019 Jun;299(6):1715-1725
pubmed: 30941555
J Cell Biochem. 2018 May;119(5):3913-3921
pubmed: 29193229
Cell Biochem Funct. 2020 Oct;38(7):880-885
pubmed: 31999854
Clin Endocrinol (Oxf). 2019 Dec;91(6):793-797
pubmed: 31482638
Biomed Res Int. 2020 Nov 6;2020:1817094
pubmed: 33224973
Endocr Connect. 2020 Nov;9(11):1075-1084
pubmed: 33112812
Artif Cells Nanomed Biotechnol. 2020 Dec;48(1):197-205
pubmed: 31851829
J Cell Physiol. 2019 Feb 18;:
pubmed: 30779115
Fertil Steril. 2019 Jun;111(6):1243-1251.e1
pubmed: 30979425
Mol Ther Nucleic Acids. 2020 Dec 15;23:614-628
pubmed: 33552682
Sci Rep. 2020 Jul 14;10(1):11608
pubmed: 32665581
Int J Mol Cell Med. 2019 Winter;8(Suppl1):19-29
pubmed: 32351906
Hum Reprod. 2018 Sep 1;33(9):1735-1748
pubmed: 30052945
J Assist Reprod Genet. 2019 Feb;36(2):211-221
pubmed: 30374732
Biol Reprod. 2020 Aug 21;103(3):548-559
pubmed: 32507875
Med Sci Monit. 2018 Apr 20;24:2384-2390
pubmed: 29674607
Cell Cycle. 2019 Oct;18(19):2538-2549
pubmed: 31405334
Braz J Med Biol Res. 2020 Oct 07;53(11):e9266
pubmed: 33053114
J Cell Mol Med. 2022 Feb;26(3):654-670
pubmed: 34989136
Reproduction. 2018 Nov;156(5):439-449
pubmed: 30328340
Nat Rev Genet. 2016 May 17;17(6):333-51
pubmed: 27184599
PeerJ. 2020 Feb 19;8:e8640
pubmed: 32117643
Gynecol Endocrinol. 2018 Sep;34(9):784-788
pubmed: 29648472
Endocrinol Metab Clin North Am. 2021 Mar;50(1):11-23
pubmed: 33518179
Cell. 2009 Feb 20;136(4):777-93
pubmed: 19239895
Front Med (Lausanne). 2019 Nov 01;6:242
pubmed: 31737638
J Mol Endocrinol. 2020 Jan;64(1):1-12
pubmed: 31710594
Int J Hematol Oncol Stem Cell Res. 2018 Jul 1;12(3):235-248
pubmed: 30595827
Sci Rep. 2019 Nov 8;9(1):16306
pubmed: 31705013
Mol Cell Endocrinol. 2020 Jan 1;499:110589
pubmed: 31557499
Mol Cell Endocrinol. 2020 Apr 15;506:110760
pubmed: 32070768
J Ovarian Res. 2021 Jan 23;14(1):19
pubmed: 33485372
Gene. 2019 Feb 20;686:250-260
pubmed: 30453069
Sci Rep. 2018 Feb 2;8(1):2202
pubmed: 29396444
Nature. 2013 Mar 21;495(7441):333-8
pubmed: 23446348
Int J Mol Sci. 2020 Dec 15;21(24):
pubmed: 33333986
Clin Epidemiol. 2013 Dec 18;6:1-13
pubmed: 24379699
Front Genet. 2019 Aug 22;10:772
pubmed: 31507635
Mol Cell Endocrinol. 2020 Mar 1;503:110697
pubmed: 31891769
Cell. 2009 Jan 23;136(2):215-33
pubmed: 19167326
J Cell Mol Med. 2021 Feb;25(4):1825-1837
pubmed: 33369146
Reprod Biol Endocrinol. 2021 Feb 23;19(1):29
pubmed: 33622342
Front Endocrinol (Lausanne). 2020 Sep 30;11:571357
pubmed: 33101204
J Cell Physiol. 2020 Feb;235(2):1366-1373
pubmed: 31297834
Mol Reprod Dev. 2018 Nov;85(11):836-848
pubmed: 29693772
Immunogenetics. 2019 Feb;71(2):87-95
pubmed: 30310937
J Assist Reprod Genet. 2021 Feb;38(2):289-304
pubmed: 33405004
J Clin Endocrinol Metab. 2020 Mar 1;105(3):
pubmed: 31730174
Endocrinology. 2017 Nov 1;158(11):3890-3899
pubmed: 28938484
PLoS Med. 2020 Jun 23;17(6):e1003132
pubmed: 32574161
Cell. 2018 Jan 25;172(3):393-407
pubmed: 29373828
Mol Med Rep. 2019 Mar;19(3):1581-1586
pubmed: 30592281
Biosci Rep. 2019 May 14;39(5):
pubmed: 31036605
Front Physiol. 2020 Jul 30;11:904
pubmed: 32848854
J Clin Endocrinol Metab. 2020 Apr 1;105(4):
pubmed: 32016412
Arch Gynecol Obstet. 2020 Apr;301(4):963-971
pubmed: 32193602
J Cell Mol Med. 2020 Jan;24(1):451-464
pubmed: 31733099
Biochem Biophys Res Commun. 2020 Apr 16;524(4):791-797
pubmed: 32019676
Cell Tissue Res. 2020 Jul;381(1):189-201
pubmed: 32468088
Endocrinology. 2019 Aug 1;160(8):1964-1981
pubmed: 31184707
Cell. 2004 Jan 23;116(2):281-97
pubmed: 14744438
J Ovarian Res. 2020 Feb 5;13(1):13
pubmed: 32024547
Mol Hum Reprod. 2019 Oct 28;25(10):638-646
pubmed: 30865275
J Cell Physiol. 2019 Jun;234(6):7970-7982
pubmed: 30378104
Fertil Steril. 2021 Mar;115(3):782-792
pubmed: 33041053
Bosn J Basic Med Sci. 2020 Aug 03;20(3):365-371
pubmed: 31999937
Front Endocrinol (Lausanne). 2019 Dec 13;10:879
pubmed: 31920988
Med Hypotheses. 2018 May;114:5-7
pubmed: 29602465
J Phys Chem B. 2021 Feb 25;125(7):1906-1915
pubmed: 33410691
Mol Cell Biochem. 2020 Feb;465(1-2):187-197
pubmed: 31894528
Front Genet. 2021 Feb 17;11:608178
pubmed: 33679867
Hum Pathol. 2018 Sep;79:212-221
pubmed: 29885402
J Biomed Sci. 2021 Jul 15;28(1):53
pubmed: 34266430